Pneumonia during pregnancy: Has modern technology improved maternal and fetal outcome?

Ne, Madinger; Js, Greenspoon; Ag, Ellrodt

doi:10.1016/0002-9378(89)90373-6

Cited by 186 publications

(110 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These include urinary tract infection [14], toxoplasmosis [15], malaria [16][17][18], and various other systemic infections, such as pneumonia [19]. Treatment of lower genital tract infections, including chlamydia and gonorrhea [20], may also have played some role, given that our protocol did not include systematic screening for these conditions.…”

Section: Discussionmentioning

confidence: 99%

Reduction in Preterm Delivery and Neonatal Mortality after the Introduction of Antenatal Cotrimoxazole Prophylaxis among HIV‐Infected Women with Low CD4 Cell Counts

et al. 2006

View full text Add to dashboard Cite

Among 255 women with CD4 cell counts <200 cells/ micro L, the percentage of preterm births (< or =34 weeks of gestation) was lower (odds ratio [OR], 0.49 [95% confidence interval {CI}, 0.24-0.98]) after cotrimoxazole prophylaxis was introduced than before; there was a significant decrease in neonatal mortality (9% to 0%; P=.01) and a trend toward increased birth weight ( beta =114 g [95% CI, -42 to 271 g]). In contrast, there were no significant changes in these parameters over the same time interval among women with CD4 cell counts > or =200 cells/ micro L.Conclusion. Antenatal provision of cotrimoxazole for HIV-infected pregnant women with low CD4 cell counts may have indirect benefits for neonatal health.

show abstract

Section: Discussionmentioning

confidence: 99%

Reduction in Preterm Delivery and Neonatal Mortality after the Introduction of Antenatal Cotrimoxazole Prophylaxis among HIV‐Infected Women with Low CD4 Cell Counts

et al. 2006

View full text Add to dashboard Cite

show abstract

“…A solid body of evidence supports the fact that systemic [2] and intrauterine infection/ inflammation [3,4] are causally linked to preterm birth. The molecular mechanisms associated with this pathologic process have been defined [5,6] and involve pro-inflammatory cytokines [7][8][9], chemokines [10][11][12], prostaglandins [13,14], and pattern recognition receptors such as Toll-like receptors [15][16][17][18].…”

Section: Introductionmentioning

confidence: 96%

Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor

Kusanovic

Espinoza

Romero

et al. 2007

The Journal of Maternal-Fetal & Neonatal Medicine

View full text Add to dashboard Cite

Objectives. Preterm parturition has been associated with decidual vascular disorders and excessive thrombin generation. The objective of this study was to examine maternal plasma concentrations of protein Z in normal pregnancies, as well as in those presenting with spontaneous preterm labor (PTL) and intrauterine bleeding during pregnancy. Study design. A cross-sectional study was designed to include patients with preterm labor and intact membranes and those with idiopathic intrauterine bleeding during pregnancy. Protein Z plasma concentrations were measured in the following groups: (1) normal pregnant women (n ¼ 71); (2) patients at term with (n ¼ 67) and without labor (n ¼ 88); (3) patients with spontaneous PTL before 34 weeks who were classified into: (a) PTL with intra-amniotic infection/inflammation (IAI; n ¼ 35), (b) PTL without IAI (n ¼ 54), and (c) patients with PTL who delivered at term (n ¼ 49); and (4) patients with idiopathic intrauterine bleeding in the second and third trimester who were divided into: (a) subsequent spontaneous PTL and delivery, and (b) term delivery. Maternal plasma protein Z concentration was measured by a specific and sensitive immunoassay. Moreover, the amniotic fluid concentration of protein Z was determined in a subset of patients with preterm labor (n ¼ 30). Results. (1) There was no correlation between maternal plasma protein Z concentration and gestational age in normal pregnant women. (2) The mean maternal plasma concentration of protein Z was significantly lower in women during spontaneous labor at term than in those not in labor (mean 2.15 mg/mL (95% CI 2.01-2.29) vs. mean 2.45+0.52 mg/mL (95% CI 2.34-2.56), respectively; p ¼ 0.001). (3) Women with PTL without IAI who delivered preterm had a significantly lower mean protein Z concentration than normal pregnant women (mean 2.12 mg/mL (95% CI 1.98-2.26) vs. mean 2.39 mg/ mL (95% CI 2.28-2.5); p ¼ 0.008). (4) Of interest, PTL with IAI was not associated with lower plasma concentrations of protein Z, nor were those with PTL who delivered at term (p 4 0.05 for each). (5) No differences were found in the maternal plasma concentrations of anti-protein Z antibodies between normal pregnancies and those with spontaneous PTL. (6) Patients with idiopathic intrauterine bleeding who had spontaneous PTL and delivery had a significantly lower mean plasma protein Z concentration than those who delivered at term (mean 1.24 mg/mL (95% CI 1.08-1.4) vs. mean 1.49+0.47 mg/mL (95% CI 1.33-1.65), respectively; p ¼ 0.03). (7) Amniotic fluid was found to contain immunoreactive protein Z. Conclusions.(1) Patients with PTL leading to preterm delivery in the absence of IAI had a significantly lower plasma concentration of protein Z than those with normal pregnancies. (2) Patients with idiopathic intrauterine bleeding and subsequently spontaneous PTL and delivery had a significantly lower plasma concentration of protein Z than those with idiopathic intrauterine bleeding who delivered at term. (3) Protein Z was present in the amniotic fluid o...

show abstract

“…En clinique humaine, il a été montré que les infections maternelles systémiques telles que les pneumonies, pyélonéphrites, infections dentaires, fièvre typhoïde ou paludisme sont associées à une augmentation du risque d'accouchement prématuré et que leur traitement permet de réduire ce risque [9][10][11][12][13]. De manière corollaire, le traitement des bactériuries asymptomatiques de la grossesse s'accompagne d'une diminution du risque d'accoucher d'un enfant de petit poids de naissance, probablement par la diminution du risque de pyélonéphrite qu'il entraîne [14].…”

Section: Le Sens Biologiqueunclassified

“…Parmi ces neuf patientes, une grossesse a été interrompue, six ont été suivies d'un avortement tardif et deux d'un accouchement très prématuré (à 24 et 30 SA). Dans cette étude, le risque relatif d'avortement tardif ou d'accouchement très prématuré était égal à 8,6 (IC95 [4,[8][9][10][11][12][13][14][15]4]). Cette étude tend donc à montrer la préexistence de l'infection par rapport à l'accouchement prématuré.…”

Section: La Chronologieunclassified

“…Chez les femmes en menace d'accouchement prématuré, des concentrations élevées d'IL-6 au niveau cervical sont associées à un haut risque d'infection du liquide amniotique (Se66 %, Sp90 %, VPP63,1 %, VPN91,7 %, RR7,7 IC95 [3,[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17]8]) [102]. De même, chez les femmes asymptomatiques, la concentration d'IL-6 au niveau cervical mesurée à 24 SA est plus élevée chez les femmes qui accoucheront pré-maturément avant 32 SA (IL-6 > 538 pg/mL 95 e percentile, OR = 9,4, IC95 [1,) [96].…”

Section: Interleukine-6 Cervicale (Il-6)unclassified

See 1 more Smart Citation

Prématurité et infection : état des connaissances

Petit

Abergel

Dedet

et al. 2012

Journal de Gynécologie Obstétrique et Biologie de la Reproducti

View full text Add to dashboard Cite

Pneumonia during pregnancy: Has modern technology improved maternal and fetal outcome?

Cited by 186 publications

References 14 publications

Reduction in Preterm Delivery and Neonatal Mortality after the Introduction of Antenatal Cotrimoxazole Prophylaxis among HIV‐Infected Women with Low CD4 Cell Counts

Reduction in Preterm Delivery and Neonatal Mortality after the Introduction of Antenatal Cotrimoxazole Prophylaxis among HIV‐Infected Women with Low CD4 Cell Counts

Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor

Prématurité et infection : état des connaissances

Contact Info

Product

Resources

About