Pneumonia Due to Varicella-Zoster Virus Reinfection in a Renal Transplant Recipient

Sato, Akihiro; Amada, Noritoshi; Kikuchi, Hiroyuki; Fukumori, Tatsuya; Haga, Izumi; Takahashi, Yūzō

doi:10.1016/j.transproceed.2009.06.195

Cited by 10 publications

(10 citation statements)

References 8 publications

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“…Disseminated disease includes infection of lung tissue resulting in VZV pneumonia with significant morbidity and mortality. 220,221 Risk of dissemination is increased in acute and chronic GVHD, as well as increased immunosuppresion. 219,220 IV acyclovir is also the recommended treatment of disseminated or invasive VZV for at least 7 days, and potentially longer in patients with extensive involvement.…”

Section: Cytomegalovirusmentioning

confidence: 99%

Respiratory Viral Infections in Solid Organ and Hematopoietic Stem Cell Transplantation

Paulsen

Danziger‐Isakov

2017

Clinics in Chest Medicine

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Respiratory viruses are common in solid organ and hematopoietic stem cell transplant recipients and a recognized cause of significant morbidity and mortality. Epidemiology, risk factors, and attributable mortality in both populations are reviewed. In addition, virus-specific prevention and treatment options, including emerging investigational therapies, are discussed for respiratory syncytial virus, influenza, adenovirus, parainfluenza, and other respiratory viruses.

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Section: Cytomegalovirusmentioning

confidence: 99%

Respiratory Viral Infections in Solid Organ and Hematopoietic Stem Cell Transplantation

Paulsen

Danziger‐Isakov

2017

Clinics in Chest Medicine

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“…Intravenous ganciclovir was given in two cases [ 5 , 9 ]. Cessation and reduction of immunosuppressant d rugs were described in four cases [ 5 , 21 , 25 , 27 , 28 ] and two studies [ 5 , 9 ] respectively. Adjunctive antibiotics were initiated in five cases [ 5 , 25 , 27 , 29 , 30 ].…”

Section: Resultsmentioning

confidence: 99%

“… (From Dec 1972 to July 2010) + Kandasamy R, et al (2009) [ 48 ] USA Case report 1 patient described. + Sato A, et al (2009) [ 27 ] Japan Case report 1 patient described. + Assi M, et al (2011) [ 29 ] USA Case report 1 patient described.…”

Section: Methodsmentioning

confidence: 99%

“… – Level 3 Kandasamy R et al (2009) [ 48 ] -58 y.o. Man with fever and progressive rash + NA – -Darrier disease related to disseminated varicella – Level 3 Sato A, et al (2009) [ 27 ] -36 y.o. Woman presented with an irritable cough + + – -Varicella pneumonia -LOS: 1 month and 10 days -One should keep the possibility of VZV reinfection in mind, in Immunocompromised patients with past history of varicella.…”

Section: Methodsmentioning

confidence: 99%

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Varicella infections in patients with end stage renal disease: a systematic review

et al. 2018

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BackgroundEnd stage renal disease (ESRD) is on the rise globally. Varicella infection among adult patients with ESRD has been reported to lead to multiple complications and even death. While varicella vaccination has been recommended in paediatric renal patients; recommendation on varicella vaccination among adult patients with ESRD remained sparse. This review is aimed at evaluating the impact of varicella infection among adult patients with ESRD and make a recommendation for vaccination.MethodsThree databases (PubMed, Embase and Cumulative Index to Nursing and Allied Health Literature (CINAHL)) were searched in April 2018 with keywords ‘varicella, chronic kidney failure, chronic kidney disease, renal replacement therapy, kidney transplantation, end stage renal disease, end stage renal failure, chicken pox, vaccine, vaccination and complications’.Results29 articles were selected for review. The studies were mainly case reports, and they included measured outcomes: prevalence of seronegativity, impact (morbidity, length of stay, and mortality) of varicella among patients with ESRD, seroconversion rates and safety of varicella vaccination. The prevalence of seronegativity among varicella-infected ESRD adults was found to be at 42 to 100%. Nineteen deaths were reported. At least 54 patients have had complications from varicella infection. Seroconversion rate post vaccination was found to be around 64–94%.ConclusionVaricella is associated with significant morbidity and mortality rates in adult patients with ESRD. Varicella vaccination should be considered for the vulnerable, seronegative patients.

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“…Herpes simplex virus and varicellazoster virus can also rarely cause severe, systemic infection, including encephalitis, esophagitis, pneumonia, keratoconjunctivitis, or hepatitis, which are associated with significant mortality. [137][138][139][140][141] Immunosuppressed patients with systemic disease may not have characteristic mucocutaneous lesions.…”

Section: Viral Infectionsmentioning

confidence: 99%

Practical Applications in Immunohistochemistry: Evaluation of Rejection and Infection in Organ Transplantation

Troxell¹,

Lanciault

2016

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Immunohistochemical analysis of tissue biopsy specimens is a crucial tool in diagnosis of both rejection and infection in patients with solid organ transplants. In the past 15 years, the concept of antibody-mediated rejection has been refined, and diagnostic criteria have been codified in renal, heart, pancreas, and lung allografts (with studies ongoing in liver, small intestine, and composite grafts), all of which include immunoanalysis for the complement split product C4d.Objectives.-To review the general concepts of C4d biology and immunoanalysis, followed by organ-allograftspecific data, and interpretative nuances for kidney, pancreas, and heart, with discussion of early literature for lung and liver biopsies. Additionally, practical applications and limitations of immunostains for infectious organisms (Polyomavirus, Adenoviridae [adenovirus], and the herpes virus family, including Herpes simplex virus, Cytomegalovirus, Human herpes virus 8, and Epstein-Barr virus) are reviewed in the context of transplant recipients.Data Sources.-Our experience and published primary and review literature.Conclusions.-Immunohistochemistry continues to have an important role in transplant pathology, most notably C4d staining in assessment of antibody-mediated rejection and assessment of viral pathogens in tissue. In all facets of transplant pathology, correlation of morphology with special studies and clinical data is critical, as is close communication with the transplant team.

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Pneumonia Due to Varicella-Zoster Virus Reinfection in a Renal Transplant Recipient

Cited by 10 publications

References 8 publications

Respiratory Viral Infections in Solid Organ and Hematopoietic Stem Cell Transplantation

Respiratory Viral Infections in Solid Organ and Hematopoietic Stem Cell Transplantation

Varicella infections in patients with end stage renal disease: a systematic review

Practical Applications in Immunohistochemistry: Evaluation of Rejection and Infection in Organ Transplantation

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