Pneumonia due to<i>Schizophyllum commune</i>in a Patient with Acute Myeloid Leukemia: Case Report and Literature Review

Kim, Hahn; Yi, Yunmi; Cho, Sung‐Yeon; Lee, Dong Gun; Chun, Hye Sun; Park, Chulmin; Kim, Yoo Jin; Park, Yeon Joon

doi:10.3947/ic.2020.0068

Cited by 8 publications

(10 citation statements)

References 19 publications

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“… 163 Mycoses due to S. commune is mostly prevalent in Japan compared with other parts of the world. 163 Ulceration of the palate, 164 brain abscess, 160 , 165 otitis externa, 166 , 167 meningitis, 168 pneumonia, 169 cutaneous granuloma, 170 and onychomycosis 171 caused by S. commune have also been reported. In the current study, we report the first case of S. commune from Qatar from a 55 year old female with rhinosinusitis.…”

Section: Discussionmentioning

confidence: 99%

Molecular epidemiology of clinical filamentous fungi in Qatar beyond Aspergillus and Fusarium with notes on the rare species

et al. 2022

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Due to an increasing number of patients at risk, (i.e., those with a highly compromised immune system and/or receiving aggressive chemotherapy treatment), invasive fungal infections (IFI) are increasingly being reported and associated with high mortality rates. Aspergillus spp., particularly A. fumigatus, is the major cause of IFI caused by filamentous fungi around the world followed by Fusarium spp., however, other fungi are emerging as human pathogens. The aim of this study was to explore the epidemiology and prevalence of the non-Aspergillus and non-Fusarium filamentous fungi in human clinical samples over an 11-years period in Qatar using molecular techniques. We recovered 53 filamentous fungal isolates from patients with various clinical conditions. Most patients were males (75.5%), 9.4% were immunocompromised, 20.7% had IFI, and 11.3% died within 30 days of diagnosis. The fungal isolates were recovered from a variety of clinical samples, including nasal cavity, wounds, respiratory samples, body fluids, eye, ear, tissue, abscess, and blood specimens. Among the fungi isolated, 49% were dematiaceous fungi, followed by Mucorales (30%), with the latter group Mucorales being the major cause of IFI (5/11, 45.5%). The current study highlights the epidemiology and spectrum of filamentous fungal genera, other than Aspergillus and Fusarium, recovered from human clinical samples in Qatar, excluding superficial infections, which can aid in surveillance of uncommon and emerging mycoses.

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Section: Discussionmentioning

confidence: 99%

Molecular epidemiology of clinical filamentous fungi in Qatar beyond Aspergillus and Fusarium with notes on the rare species

et al. 2022

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“…The rate of human infections caused by S. commune has been increasing recently [3]. Several cases have been reported in immunocompromised and immunocompetent patients [4][5][6][7][8][9][10][11][12][13][14][15][16]. We reviewed published reports of S. commune-induced invasive infections in immunocompetent patients (Table 1).…”

Section: Discussionmentioning

confidence: 99%

“…A limitation of our study is that we could not conduct an antifungal susceptibility test for our case. In general, S. commune infections are easily manageable, and the mean minimum inhibitory concentrations observed for itraconazole remain low [8,17].…”

Section: Discussionmentioning

confidence: 99%

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A Rare Case of Bronchiectasis with Mucoid Impaction Caused by Schizophyllum commune in an Immunocompetent Woman in South Korea

et al. 2023

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Schizophyllum commune is one of most widely distributed fungal species, often found on dead and decaying organic matter. Only a few cases of S. commune infections in immunocompetent patients, including the sinus, sino-orbital, bronchopulmonary, and extra-pulmonary areas have been reported. A 52-year-old female patient presented with symptoms of cough, whitish sputum, and chest discomfort lasting approximately one month. The patient denied any relevant medical history. Chest radiography revealed a mass-like consolidation at the right lower lobe. Bronchoscopy showed thick, white-yellowish mucoid plugs on several bronchi on the right middle lobe. Transbronchial biopsy and aspiration were performed. Gomori's methenamine silver staining on a prepared paraffin block and fungal culture revealed a few scattered degenerated fungal hyphae. DNA amplification and sequencing analysis of the Internal Transcribed Spacer gene demonstrated 100% identity with S. commune; access number MK029865.1. The patient was diagnosed with bronchiectasis with mucoid impaction caused by S. commune fungal infection and recovered fully after 4 weeks of oral administration of itraconazole 200 mg twice a day. In Korea, there have been only two cases of fungal infections caused by S. commune in immunocompetent patients. The cases were allergic fungal sinusitis and sino-orbital infection. This report provides additional evidence that invasive fungal infection by S. commune is possible in immunocompetent patients.

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“…IFIs caused by rare fungi are also increasing [ 9 - 11 ]. However, this article focused on IFIs, specifically invasive candidiasis, aspergillosis, and mucormycosis in patients with hematologic diseases.…”

Section: Introductionmentioning

confidence: 99%

Advances in prophylaxis and treatment of invasive fungal infections: perspectives on hematologic diseases

et al. 2022

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Invasive fungal infections (IFIs) are common causes of mortality and morbidity in patients with hematologic diseases. Delayed initiation of antifungal treatment is related to mortality. Aspergillus sp. is the leading cause of IFI followed by Candida sp. Diagnosis is often challenging owing to variable conditions related to underlying diseases. Clinical suspect and prompt management is important. Imaging, biopsy, and non-culture-based tests must be considered together. New diagnostic procedures have been improved, including antigen-based assays and molecular detection of fungal DNA. Among hematologic diseases, patients with acute myeloid leukemia, myelodysplastic syndrome, recipients of hematopoietic stem cell transplantation are at high risk for IFIs. Antifungal prophylaxis is recommended for these high-risk patients. There are continuous attempts to achieve ideal management of IFIs. Scoring system for quality control has been developed with important recommendations of current guidelines. Higher adherence to guidelines is related to decreased mortality in IFIs.

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Pneumonia due toSchizophyllum communein a Patient with Acute Myeloid Leukemia: Case Report and Literature Review

Cited by 8 publications

References 19 publications

Molecular epidemiology of clinical filamentous fungi in Qatar beyond Aspergillus and Fusarium with notes on the rare species

Molecular epidemiology of clinical filamentous fungi in Qatar beyond Aspergillus and Fusarium with notes on the rare species

A Rare Case of Bronchiectasis with Mucoid Impaction Caused by Schizophyllum commune in an Immunocompetent Woman in South Korea

Advances in prophylaxis and treatment of invasive fungal infections: perspectives on hematologic diseases

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