Pneumocystis carinii, un défi pour le biologiste

Dei, E.; Soulez, B; Palluault, F; Charet, P.; Camus, Daniel

doi:10.4267/10608/4182

Cited by 20 publications

(25 citation statements)

References 14 publications

(15 reference statements)

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“…This model presents at least two advantages. First, the infection occurs in the absence of drug-induced immunodepression (Soulez et ai, 1989;Dei-Cas et al, 1990a). The rabbit can there fore be used to investigate host-parasite interactions in a nonimmunodepressed natural host, especially pri mary Pneumocystis infection.…”

Section: Discussionmentioning

confidence: 99%

“…not submitted to immunosuppressive drugs) young rabbits are spontaneously and heavily infected by P. carinii at weaning (28-dayold rabbits) (Soulez et al, 1989;Dei-Cas et al, 1990a) but we do not know when, nor how P. carinii infects them. Most rabbits recover spontaneously from this spontaneous P. carinii pneumonia (PCP) within 2-4 weeks (Soulez et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

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In uterotransmission ofPneumocystis cariniisp. f.Oryctolagi

et al. 1997

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Summary :Although vertical transmission of Pneumocystis in human or animal hosts has often been suspected, no evidence demonstrating this infection route has been furnished until now. This widespread parasite is constantly found in the lungs of rabbits, which spontaneously develop a benign pneumocystosis at weaning.However, the infection source, the method of entry of Pneumocystis organisms into the rabbit and when this mammal is infected, remain to be known. As a few parasites have been

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In uterotransmission ofPneumocystis cariniisp. f.Oryctolagi

et al. 1997

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“…However, the presence of the parasite in other organs is occasionally reported in man (14,66) and, recently, we have found P. carinii in several extrapulmonary sites in deeply immunosuppressed laboratory animals (unpublished results). figure 1 shows the generally accepted life cycle of P. carinii (19,53,56). It includes the following parasite stages: an amoeboidal mononucleate trophozoite, a precyst and a mature cyst containing eight intracystic bodies that will evolve to trophozoite forms.…”

Section: The Life Cycle Of Pneumocystis Cariniimentioning

confidence: 99%

“…Surface structures also evolve through the life cycle: the trophozoite and the early precyst have a thin pellicle consisting of a plasma membrane and an electron-dense outer layer, whereas the other precystic stages and mature cyst have a thick pellicle (named "cyst wall" henceforth) consisting of a plasma membrane, an electron-lucent middle layer and an electron-dense outer layer ( Fig. 1) (19,47,53,56).…”

Section: The Life Cycle Of Pneumocystis Cariniimentioning

confidence: 99%

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Is Pneumocystis carinii a deep mycosis-like agent?

et al. 1992

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Pneumocystis carinii is a widespread eukaryotic microorganism found in the lungs of healthy mammals, including humans. It is able to proliferate extensively in the alveoli, becoming an important agent of severe pneumonitis in immunosuppressed hosts, especially in persons suffering from AIDS. The taxonomic position of P. carinii is uncertain. Typical cytoplasmic organelles of eukaryotic cells have been found and described in the parasite. Biochemical research is hindered by the lack of an efficient in vitro culture system. Results of comparative study of nucleic acid sequences suggest that Pneumocystis is a fungus. However, ultrastructural, biochemical and nucleic acid homology insights appear as clearly insufficient to class Pneumocystis. Pneumocystis infection might be acquired, as deep mycoses, from environmental sources through the respiratory tract. Thus, the hypothesis of an environmental stage of the parasite must be considered. Pneumocystis might be seen as a widespread pathogenic dimorphous fungus. As fungal agents, P. carinii is able to disseminate from the infected lung to other organs. However, deep mycoses and pneumocystosis induce different histopathological changes in the host. Furthermore, deep fungal infections, unlike pneumocystosis, cannot be transmitted from one infested host to another one. Beside these two aspects, pneumocystosis shares many features with deep mycoses. Research on the epidemiology of pneumocystosis is needed.

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Pneumocystis carinii-Pneumonie nach 40 Jahren

Nouza

1992

Infection

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Forty years ago, Pneumocystis carinii was identified by Czech researchers J. Vanĕk and O. Jírovec as the causative agent of interstitial plasma cell pneumonia in infants. At present, it is the commonest pulmonary pathogen in AIDS patients. This review summarizes the experience and latest data on the etiopathogenesis, pathology, clinical presentation, diagnosis and therapy of P. carinii pneumonia.

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Pneumocystis carinii, un défi pour le biologiste

Cited by 20 publications

References 14 publications

In uterotransmission ofPneumocystis cariniisp. f.Oryctolagi

In uterotransmission ofPneumocystis cariniisp. f.Oryctolagi

Is Pneumocystis carinii a deep mycosis-like agent?

Pneumocystis carinii-Pneumonie nach 40 Jahren

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