Pneumococcal pneumonia suppresses allergy development but preserves respiratory tolerance in mice

Hartmann, Carolin; Behrendt, Ann-Kathrin; Henken, Stefanie; Wölbeling, Florian; Maus, Ulrich A.; Hansen, Gesine

doi:10.1016/j.imlet.2014.12.001

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…Second, total IgE may also be associated with the mechanisms of suppressive roles of S. pneumoniae. In fact, the past study in a mouse model revealed that infection with S. pneumoniae decreased serum IgE levels and reduced eosinophil counts in bronchoalveolar fluid [15]. Collectively, total IgE rather than type 2 immune responses and/or eosinophilic inflammation may have an important role in the suppressive effects of S. pneumoniae colonization on acute exacerbation of asthma.…”

Section: Discussionmentioning

confidence: 97%

Allergic Sensitization Is Crucial for the Suppressive Role of Streptococcus pneumoniae in the Acute Exacerbation of Asthma

Kama

Kitahara

Enseki

et al. 2022

Int Arch Allergy Immunol

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Introduction: Allergic sensitization is an important factor in the development, severity, and exacerbation of asthma, which is attributed to type 2 (T2) inflammation. Evidence suggests that respiratory bacterial pathogens (e.g., Streptococcus pneumoniae) exert suppressive effects on airway T2 inflammation. To clarify the role of allergic inflammation in bacterial colonization in asthma based on allergic sensitization, we investigated pharyngeal bacterial colonization, biomarkers (e.g., serum eosinophil cationic protein (ECP) and cytokines/chemokines), and symptoms in the acute exacerbation of childhood asthma. Methods: Pharyngeal samples were collected from 53 children (mean/median age 2.7/2.5 years). Serum levels of total and allergen-specific IgE against aeroallergens, ECP, and 17 cytokines/chemokines were measured. Results: Allergic sensitization was recognized in 62.2% patients. S. pneumoniae, Moraxella catarrhalis, Haemophilus influenzae, and other bacteria were detected in 47.1%, 11.3%, 11.3%, and 30.1% of all patients, respectively. Patients with S. pneumoniae had a significantly shorter duration of wheezing than those without (4.7 ± 3.6 vs. 7.1 ± 3.5 days, p = 0.024). In patients with allergic sensitization, patients with S. pneumoniae had a significantly shorter duration of wheezing than those without (4.0 ± 3.6 vs. 7.7 ± 4.0 days, p = 0.003). Serum total IgE was significantly lower in patients with S. pneumoniae than in those without (81.9 [7.8–894] vs. 287 [4.4–1,840] IU/mL, p = 0.014). Serum ECP was significantly higher (33.1 [2–109] vs. 7.8 [3–35] ng/mL, p = 0.042), and IFN-γ was significantly lower (5.6 [4–10] vs. 16.4 [7–28] pg/mL, p = 0.032) in patients with allergic sensitization than those without. Discussion/Conclusion: Our results suggested that the suppressive effects of S. pneumoniae colonization were observed only in patients with allergic sensitization, wherein serum total IgE, ECP, and IFN-γ may have an important role on acute exacerbation of asthma.

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Section: Discussionmentioning

confidence: 97%

Allergic Sensitization Is Crucial for the Suppressive Role of Streptococcus pneumoniae in the Acute Exacerbation of Asthma

Kama

Kitahara

Enseki

et al. 2022

Int Arch Allergy Immunol

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“… 106 Experimentally, it was demonstrated that killed or live S pneumoniae administered before, during, or after OVA sensitization attenuated allergic inflammation. 107 , 108 …”

Section: Bacterial Infections and Asthma Exacerbationsmentioning

confidence: 99%

Asthma-associated bacterial infections: Are they protective or deleterious?

Fraga-Silva¹,

Boko²,

Martins³

et al. 2023

Journal of Allergy and Clinical Immunology: Global

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“…But killed S . pneumoniae showed some potential as an effective immunomodulatory therapy in a murine model of asthma [ 78 ]. We summarized the results of studies assessing interaction between bacterial agents or antibiotic exposure and murine models of asthma in Table 2 .…”

Section: Animal Models and The Microbiomementioning

confidence: 99%

Microbiome and Asthma: What Have Experimental Models Already Taught Us?

Bonamichi-Santos

Aun

Agondi

et al. 2015

Journal of Immunology Research

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Asthma is a chronic inflammatory disease that imposes a substantial burden on patients, their families, and the community. Although many aspects of the pathogenesis of classical allergic asthma are well known by the scientific community, other points are not yet understood. Experimental asthma models, particularly murine models, have been used for over 100 years in order to better understand the immunopathology of asthma. It has been shown that human microbiome is an important component in the development of the immune system. Furthermore, the occurrence of many inflammatory diseases is influenced by the presence of microbes. Again, experimental models of asthma have helped researchers to understand the relationship between the microbiome and respiratory inflammation. In this review, we discuss the evolution of murine models of asthma and approach the major studies involving the microbiome and asthma.

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Pneumococcal pneumonia suppresses allergy development but preserves respiratory tolerance in mice

Cited by 5 publications

References 34 publications

Allergic Sensitization Is Crucial for the Suppressive Role of Streptococcus pneumoniae in the Acute Exacerbation of Asthma

Allergic Sensitization Is Crucial for the Suppressive Role of Streptococcus pneumoniae in the Acute Exacerbation of Asthma

Asthma-associated bacterial infections: Are they protective or deleterious?

Microbiome and Asthma: What Have Experimental Models Already Taught Us?

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