Pneumococcal coinfection in COVID‐19 patients

Toombs, Jessica M.; Abbeele, Koenraad Van den; Democratis, Jane; Mandal, Amit K J; Missouris, Constantinos G

doi:10.1002/jmv.26278

Cited by 18 publications

(19 citation statements)

References 7 publications

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“…Elevated markers of liver injury, high C-reactive protein, and low lymphocytes at admission were associated with adverse outcomes in Chinese patients with COVID-19 ( 28 , 29 ), but we found no significant changes of the abovementioned parameters possibly associated with medication concealing. The occurrence and the cumulative value of identified co-infections during hospitalization were positively associated with longer ICU stay in both survivors and non-survivors, and this may be linked with the disruption of host defenses that are no longer able to prevent pathogen migrations ( 30 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Severe COVID-19 Patients Admitted to an Intensive Care Unit in Lombardy During the Italian Pandemic

et al. 2021

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Italy was one of the worst affected European countries during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. More than 50% of Italian cases occurred in the northern region of Lombardy, where the saturation of health services between March and April 2020 forced hospitals to allocate patients according to available resources. Eighteen severe coronavirus disease 2019 (COVID-19) patients were admitted to our hospital needing intensive support. Given the disease fatality, we investigated the patients' characteristics to identify mortality predictors. We counted seven deaths from multiple organ failure, two from septic shock, and two from collapsed lungs. The maximum case fatality was observed in patients who contracted SARS-CoV-2 in hospitals. The fatal outcome was associated with the following baseline characteristics: polymorbidity (OR 2.519, p = 0.048), low body mass index (OR 2.288, p = 0.031), low hemoglobin (OR 3.012, p = 0.046), and antithrombin III (OR 1.172, p = 0.048), along with a worsening of PaO2/FiO2 ratio in the first 72 h after admission (OR 1.067, p = 0.031). The occurrence of co-infections during hospitalization was associated with a longer need for intensive care (B = 4.511, p = 0.001). More information is needed to inform intensive care for patients with severe COVID-19, but our findings would certainly contribute to shed some light on this unpredictable and multifaceted disease.

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Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Severe COVID-19 Patients Admitted to an Intensive Care Unit in Lombardy During the Italian Pandemic

et al. 2021

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“…The most common bacteria were M. pneumonia , P. aeruginosa, and Haemophilus influenza . Toombs et al [ 21 ] found that two COVID-19 patients (0.4%) were co-infected with S. pneumoniae , as determined by blood culture positivity upon hospitalization in the United Kingdom. These results support the hypothesis of secondary infection in COVID 19 patients.…”

Section: Discussionmentioning

confidence: 99%

Bacterial co-infections and antibiotic resistance in patients with COVID-19

Mahmoudi

2020

GMS Hygiene and Infection Control; 15:Doc35

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“…Clinicians are challenged with the additional burden of possible coinfections with other tropical diseases that have the potential to complicate the course of illness [26]. Coinfections with COVID-19 have been reported with multiple bacteria and viruses [27][28][29][30][31]. Nevertheless, coinfection with dengue viruses and SARS-CoV-2 are still scarce, with only a few reports describing false-positive dengue serology [24,32].…”

Section: Discussionmentioning

confidence: 99%

Coronavirus disease 2019 and dengue: two case reports

et al. 2021

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Background The pandemic of this century has overwhelmed the healthcare systems of affected countries, and all resources have been diverted to coronavirus disease 2019. At the onset, coronavirus disease 2019 can present as any other acute febrile undifferentiated illness. In tropical regions, clinicians are increasingly challenged to differentiate these febrile illnesses without the use of diagnostics. With this pandemic, many of these tropical diseases are neglected and go underreported. Dengue is holoendemic in the Maldives, and dengue viruses circulate throughout the year. Reports about coinfections with dengue virus and severe acute respiratory syndrome coronavirus 2 are scarce, and the outcome and the dynamics of the disease may be altered in the presence of coinfection. We have described the clinical manifestation and serial laboratory profile, and highlighted the atypical findings uncommon in dengue infection. Case presentation Case 1 was a 39-year old Asian male, presented on day 6 of dengue infection with warning signs. Reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 that was done as per hospital protocol was found to be positive. Case 2 was a 38-year old Asian male, was admitted on day 5 of illness with symptoms of acute respiratory infection with positive reverse transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2. Evaluation of progressive leukopenia and thrombocytopenia showed positive dengue serology. Conclusion Clinicians must be conscientious when working on the differential diagnosis of possible tropical diseases in cases of coronavirus disease 2019, specifically, when patients develop hemoconcentration, thrombocytopenia, and transaminitis with elevated expression of aspartate higher than alanine transaminase, which is frequently observed in dengue infection. Caution must be taken during the administration of intravenous fluids when treating patients with coronavirus disease 2019 and dengue coinfection, as coronavirus disease 2019 patients are more prone to develop pulmonary edema. Timely diagnosis and appropriate management are essential to avoid the devastating complications of severe forms of dengue infection. It is important to repeat and reconfirm the dengue serology in coronavirus disease 2019 patients to avoid false positivity. Diligence and care must be taken not to neglect other endemic tropical diseases in the region during the present pandemic.

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Pneumococcal coinfection in COVID‐19 patients

Abstract: We would like to report our experience of 2 patients co‐infected with Streptococcus pneumoniae (S. pneumoniae) and coronavirus disease 2019 (Covid‐19) in the United Kingdom. This article is protected by copyright. All rights reserved.

Cited by 18 publications

References 7 publications

Clinical Characteristics of Severe COVID-19 Patients Admitted to an Intensive Care Unit in Lombardy During the Italian Pandemic

Clinical Characteristics of Severe COVID-19 Patients Admitted to an Intensive Care Unit in Lombardy During the Italian Pandemic

Bacterial co-infections and antibiotic resistance in patients with COVID-19

Coronavirus disease 2019 and dengue: two case reports

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