Pneumatosis Intestinalis with Associated Retroperitoneal Air

Culver, Gordon J.

doi:10.1001/jama.1963.63710020023023e

Cited by 17 publications

(7 citation statements)

References 2 publications

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“…PI associated with asthma is extremely rare and, to our knowledge, only three cases have been reported worldwide 4 , 5 , 6 . We present a case of a patient who was diagnosed with asthma and later developed PI, which was detected incidentally by follow-up X-ray.…”

Section: Introductionmentioning

confidence: 88%

Pneumatosis Intestinalis Complicated by Pneumoperitoneum in a Patient with Asthma

et al. 2014

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Pneumatosis intestinalis (PI) is a very rare condition that is defined as the presence of gas within the subserosal or submucosal layer of the bowel. PI has been described in association with a variety of conditions including gastrointestinal tract disorders, pulmonary diseases, connective tissue disorders, organ transplantation, leukemia, and various immunodeficiency states. We report a rare case of a 74-year-old woman who complained of dyspnea during the management of acute asthma exacerbation and developed PI; but, it improved without any treatment.

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Section: Introductionmentioning

confidence: 88%

Pneumatosis Intestinalis Complicated by Pneumoperitoneum in a Patient with Asthma

et al. 2014

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“…[11] retrouvent chez le même malade non seulement le pneumom édiastin et la pneumatose kystique du côlon, mais aussi une bande d'air paravertébrale droite entre D" et I)12, indiquant le cheminement de l'air. Culver [5] voit survenir une pneumatose kys tique du côlon droit chez un asthm atique lors de l'application d'une assistance ventilatoire par pression positive interm ittente. La réparti est-elle une complication de l'emphysème pulmonaire ?…”

Section: Discussionunclassified

“…en 1958 [18] une maladie pulmonaire est associée à une pneum atose intestinale localisée au côlon. Enfin, Creevey et coll., en 1958 [4], Mattliens, 1954 [16], et Culeer, 1963 [5] font chacun la même constatation chez leur patient. A cette série déjà impression nante et certainem ent incomplète, nous pouvons ajouter 3 autres cas de pneum atose kystique intestinale à localisation recto-sigmoï dienne et colique, observés à l'Hôpital cantonal de Lausanne durant ces quatre dernières années.…”

Section: Par S Montani Et M Landryunclassified

La pneumatose kystique intestinale est-elle une complication de l’emphysème pulmonaire? A propos de trois cas de pneumatose colique dite «primaire»

Montani¹,

Landry²

1965

Digestion

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“…Moreover, this notion arose with reference to some observations reported in the literature. [10][11][12][13][14][15][16][17] By electron microscopic study in one case of PCI, Haboubi et al 14 identified some ultrastructural evidence of the cystic spaces being dilated lymphatics in nature. The evidence was 2-fold.…”

Section: Commentmentioning

confidence: 99%

“…All of these have supported the lymphatic theory in the pathogenesis of PCI. [13][14][15][16][17] However, to our knowledge, no conclusion has been made.…”

mentioning

confidence: 99%

Is Pneumatosis Cystoides Intestinalis Gas-Distended and Ruptured Lymphatics?: Reappraisal by Immunohistochemistry

Gui

Zhou

Eidus

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Pneumatosis cystoides intestinalis (PCI) is a condition with multiple gas-filled cysts within the bowel wall, associated with diverse background diseases. Its pathogenesis is still a mystery. Some previous observations scattered in the literature have suggested an association of the cystic spaces in PCI with the lymphatics.Objective.-To further investigate whether PCI results from the ballooning of gas-filled lymphatic channels.Design.-We did immunostaining of podoplanin, a mucoprotein preferentially expressed in lymphatic endothelial cells, in 13 cases (8 men, 5 women; age range, 18-80 years) of PCI. Ten cases were diagnosed in resected segments of bowel and 3 in biopsies. Pneumatosis was seen in the right side of the colon (9 cases), transverse colon (1 case), sigmoid colon (1 case), and small bowel (2 cases). In addition, immunostaining for CD31, calretinin, WT1, CD68, smooth muscle actin, desmin, vimentin, and cytokeratins was also performed for comparison and correlation.Results.-A strong immunopositivity of podoplanin was seen in a condensed linear structure in the pericystic interstitium in 100% of the cases, but was not seen in the overlying giant and flat cells that were all CD68-positive histiocytes. Meanwhile, the podoplanin-expressing structure was negative for calretinin and WT1, which ruled out the possible mesothelial origin. There were coexistent variable immunopositivity of smooth muscle actin, which suggests an admixture of myofibroblasts. These findings indicated that the PCI cases were gas-distended lymphatics with the lymphatic epithelium ruptured and embedded in the reactive histiocytes and giant cells.Conclusion.-Our findings support the lymphatic theory about the pathogenesis of PCI.

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Pneumatosis Intestinalis with Associated Retroperitoneal Air

Cited by 17 publications

References 2 publications

Pneumatosis Intestinalis Complicated by Pneumoperitoneum in a Patient with Asthma

Pneumatosis Intestinalis Complicated by Pneumoperitoneum in a Patient with Asthma

La pneumatose kystique intestinale est-elle une complication de l’emphysème pulmonaire? A propos de trois cas de pneumatose colique dite «primaire»

Is Pneumatosis Cystoides Intestinalis Gas-Distended and Ruptured Lymphatics?: Reappraisal by Immunohistochemistry

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