PMWS-like Lesions in Preweaned Crossbred Piglets Naturally Infected with Porcine Circovirus 2 in India

Sharma, Rinku

doi:10.14737/journal.aavs/2014.2.1.26.30

Cited by 1 publication

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References 31 publications

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“…Lung showed severe interstitial pneumonia characterized by thickening of alveolar septa, infiltration of MNCs, compensatory emphysema and presence of oedematous fluid in some alveoli, degeneration and desquamation of bronchial and bronchiolar lining epithelium, depletion of BALT, endothelial cell swelling and fibrinous thrombi in the Lymphoid depletion in mesenteric and inguinal lymphnodes along with hyperplasia of follicular dendritic cells were noticed in most of PMW S affected pigs (Roselle et al 1999;Segales and Domingo, 2002). The prominent finding of PMW S was presence of sharply demarcated spherical intracytoplasmic inclusions in histocytic cells as observed by others (Sharma and Saikumar, 2014). Severe macrophage infiltration, granulomatous lesions and amphophilic inclusion bodies were reported in tissues of PPV and PCV2 co infected animals suggesting cofactors are important in the pathogenesis of PMW S (Kennedy et al 2000).…”

Section: Histopathologymentioning

confidence: 95%

Pathology of PMWS Associated with Classical Swine Fever Virus, Porcine Parvo Virus and Multidrug Resistant Enteric Escherichia coli Infections in an Organized Swine Farm, Rajasthan, India

Das

Sethi

John

et al. 2022

IJAR

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Background: Postweaning multisystemic wasting syndrome (PMWS) is caused by porcine circovirus type 2 (PCV2). It is a globally emerging clinical condition which affects nursing piglets and growing pigs. PCV2 requires various cofactors for fully development of PMWS. The present report describes the pathology of PMWS associated with classical swine fever virus (CSFV), porcine parvo virus (PPV) and multidrug resistant enteric Escherichia coli infections in an organized swine farm, Rajasthan. In India, this is the first report on pathology of PMWS associated with all the three viruses and multidrug resistant enteric colibacillosis. Methods: Detailed necropsy was conducted on pig carcass submitted to Post-mortem Facility, Division of Pathology, ICAR-Indian Veterinary Research Institute (IVRI), Izatnagar in the year 2017 from an organized swine farm, Rajasthan, India. Heart blood and diarrhoeic intestinal contents were collected aseptically and stored separately at 4°C for bacteriological examination and antibiotic sensitivity test. Tissue samples were collected in sterile container and stored at -40°C for DNA and RNA extraction and polymerase chain reaction (PCR) and also collected in 10% neutral buffered saline for histopathological processing. Result: The organized farm was having history of 33% (200/600) of mortality among 2 months to 6 months old piglets. Gross lesions were wasting, lymphadenopathy, non-collapsed lungs, hydropericardium, hepatomegaly, icterus, enteritis and pale kidneys, button shaped ulcers in the caecum and colon etc. Histopathologically, lymphoid depletion, reticuloendothelial cell proliferation in lymphoid tissue, fibrin thrombi in spleen, severe hepatitis, interstitial pneumonia, interstitial nephritis, severe necrosis in large intestine, meningitis, perivascular cuffing (PVC), gliosis, neuronal degeneration in cerebrum etc were observed. Molecular diagnosis and bacteriological examination confirmed presence of PCV2, PPV, CSFV and multidrug resistant Escherichia coli.

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Section: Histopathologymentioning

confidence: 95%