PM2.5-induced airway inflammation and hyperresponsiveness in NC/Nga mice

Oginö, Kazuhíde; Nagaoka, Kenjiro; Okuda, Tomoaki; Oka, Akira; Kubo, Masayuki; Eguchi, Eri; Fujikura, Yoshihisa

doi:10.1002/tox.22303

Cited by 51 publications

(33 citation statements)

References 41 publications

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“…PM 2.5 was associated with airway inflammation and hyper responsiveness [12]. Systemic oxidative stress and inflammation were also associated with PM 2.5 [13] .…”

Section: Discussionmentioning

confidence: 99%

Association Between Environmental Particulate Matter and Carpal Tunnel Syndrome in Patients Undergoing Hemodialysis

Weng

Yen

et al. 2017

Kidney Blood Press Res

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Background/Aims: The deposition of β2-microglobulin induced by reactive inflammation causing carpal tunnel syndrome (CTS) is one of the complications of dialysis-related amyloidosis in maintenance hemodialysis (MHD) patients. Air pollution levels, especially particulate matter with an aerodynamic diameter of <2.5 mm (PM_2.5)_, have significantly been associated with the elevation of systemic inflammatory markers. There is no previous research on possible associations between CTS and PM_2.5. Methods: This study enrolled 866 MHD patients treated at the outpatient HD centers. Senior neurologists diagnosed the presence of CTS. Air pollution levels were recorded by a network of 27 monitoring stations near or in the patients’ living areas throughout Taiwan. The 12- and 24-month average concentrations of PM with an aerodynamic diameter of <10 and <2.5 mm (PM₁₀ and PM_2.5, respectively), sulfur dioxide, nitrogen dioxide, carbon monoxide, and ozone were included. Results: Multivariate logistic regression analyses showed that HD duration, the normalized protein catabolic rate (nPCR), hypoalbuminemia (albumin < 4 g/dl), and the mean previous 12-month environmental PM_2.5 were positively associated with CTS; HD duration, nPCR, hypoalbuminemia (albumin < 4 g/dl), and the mean previous 24-month environmental PM_2.5 were positively associated with CTS; HD duration, hypoalbuminemia (albumin < 4 g/dl), and previous 12-month PM_2.5 excess days were positively associated with CTS; and HD duration, nPCR, hypoalbuminemia (albumin < 4 g/dl), and previous 24-month PM_2.5 excess days were positively associated with CTS. Conclusion: PM_2.5 levels and PM_2.5 excessing days were positively correlated with CTS.

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“…PM 2.5 was associated with airway inflammation and hyper responsiveness [12]. Systemic oxidative stress and inflammation were also associated with PM 2.5 [13] .…”

Section: Discussionmentioning

confidence: 99%

Association Between Environmental Particulate Matter and Carpal Tunnel Syndrome in Patients Undergoing Hemodialysis

Weng

Yen

et al. 2017

Kidney Blood Press Res

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“…In addition, PM can induce asthmatic airway inammation by increasing the number of total cells and IL-5, IL-22, eosinophilactivated chemokine 2, and metal lothionein 3 in mouse alveolar lavage uid. 24 Intratracheal instillation is a convenient and effective method used with PM to induce ALI in mice. 25 Compared with the models using whole-body inhalation chambers and nasal drip, this model requires one single dose of intratracheal instillation of PM with the features of accuracy and efficiency.…”

Section: Discussionmentioning

confidence: 99%

Walnut protein isolates attenuate particulate matter-induced lung and cardiac injury in mice and zebra fish

Zhang

Liu²,

Fan

et al. 2019

RSC Adv.

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“…The primer sequences used are shown in Table 1. GAPDH (Glyceraldehyde 3-phosphate dehydrogenase) was used as an internal control (Ogino et al 2014(Ogino et al , 2016.…”

Section: Quantitative Real-time Pcr (Qrt-pcr) Analysismentioning

confidence: 99%

Human lactoferrin induces asthmatic symptoms in NC/Nga mice

et al. 2017

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Lactoferrin in commercial supplements is known to exert anti‐viral and anti‐allergic effects. However, this is the first study to evaluate the induction of allergic airway inflammation in NC/Nga mice. Human lactoferrin was administered intraperitoneally with aluminum oxide for sensitization. Five days later, lactoferrin was inoculated intranasally for 5 days, and then on the 12th day, the single inoculation of lactoferrin intranasally was performed as a challenge. On the 13th day, airway hypersensitivity was assessed (AHR), a bronchoalveolar fluid (BALF) cell analysis was conducted, serum IgE and serum lactoferrin‐specific IgG and IgE levels as well as the mRNA expression levels of cytokines and chemokines in the lung were measured, and a histopathological analysis of the lung was performed. Human lactoferrin increased AHR, the number of eosinophils in BALF, serum lactoferrin‐specific IgG levels, and the mRNA levels of IL‐13, eotaxin 1, and eotaxin 2. Moreover, the accumulation of inflammatory cells around the bronchus and the immunohistochemical localization of arginase I and human lactoferrin were detected. Collectively, these results indicate that human lactoferrin induced allergic airway inflammation in mice. Therefore, the commercial use of human lactoferrin in supplements warrants more intensive study.

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PM2.5-induced airway inflammation and hyperresponsiveness in NC/Nga mice

Cited by 51 publications

References 41 publications

Association Between Environmental Particulate Matter and Carpal Tunnel Syndrome in Patients Undergoing Hemodialysis

Association Between Environmental Particulate Matter and Carpal Tunnel Syndrome in Patients Undergoing Hemodialysis

Walnut protein isolates attenuate particulate matter-induced lung and cardiac injury in mice and zebra fish

Human lactoferrin induces asthmatic symptoms in NC/Nga mice

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