PM2.5 aggravates NQO1-induced mucus hyper-secretion through release of neutrophil extracellular traps in an asthma model

He, Xiang; Zhang, Lei; Xiong, Anying; Qin, Ran; Wang, Junyi; Wu, Dehong; Niu, Ben; Liu, Shengbin; Li, Guoping

doi:10.1016/j.ecoenv.2021.112272

Cited by 18 publications

(15 citation statements)

References 30 publications

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“…Patients with severe asthma and COPD often exhibit greater levels of oxidative stress biomarkers, with increased levels correlating with worsened symptoms, decreased lung function, and corticosteroid insensitivity [37,75,[78][79][80][81][82][83]. This oxidative burden is achieved by exposure to environmental and cellular sources of RONS.…”

Section: Factors Contributing To Oxidative Stressmentioning

confidence: 99%

“…Ozone is an oxidant that induces Th17-mediated neutrophilic airway inflammation and is associated with decreased corticosteroid sensitivity [79,103,104]. Exposure to other environmental pollutants, such as diesel exhaust and <2.5 µm particulate matter (PM 2.5 ), also induces high levels of oxidative stress in the lung [82,83,105]. Similar to ozone, diesel exhaust induces Th17 inflammation with increases in IL-17A levels and neutrophil infiltration [106,107].…”

Section: Environmental Sourcesmentioning

confidence: 99%

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Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD

et al. 2021

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Corticosteroid insensitivity is a key characteristic of patients with severe asthma and COPD. These individuals experience greater pulmonary oxidative stress and inflammation, which contribute to diminished lung function and frequent exacerbations despite the often and prolonged use of systemic, high dose corticosteroids. Reactive oxygen and nitrogen species (RONS) promote corticosteroid insensitivity by disrupting glucocorticoid receptor (GR) signaling, leading to the sustained activation of pro-inflammatory pathways in immune and airway structural cells. Studies in asthma and COPD models suggest that corticosteroids need a balanced redox environment to be effective and to reduce airway inflammation. In this review, we discuss how oxidative stress contributes to corticosteroid insensitivity and the importance of optimizing endogenous antioxidant responses to enhance corticosteroid sensitivity. Future studies should aim to identify how antioxidant-based therapies can complement corticosteroids to reduce the need for prolonged high dose regimens in patients with severe asthma and COPD.

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Section: Factors Contributing To Oxidative Stressmentioning

confidence: 99%

Section: Environmental Sourcesmentioning

confidence: 99%

Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD

et al. 2021

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“…Preparation of PM2.5 PM2.5 was collected as described according to the previous publication. 13,14 Briefly, PM2.5 samples were collected from October to December 2018 using an air sampler on the open-air roof of a ten-story building of the third people's Hospital of Chengdu. To eliminate the contamination, the filters were preheated at 550°C.…”

Section: Methodsmentioning

confidence: 99%

PM2.5 Aggravated OVA-Induced Epithelial Tight Junction Disruption Through Fas Associated via Death Domain-Dependent Apoptosis in Asthmatic Mice

He¹,

Zhang²,

Hu³

et al. 2021

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“…PM2.5 enters the bronchi directly through the nasal cavity and then connects to the lungs, causing bronchitis, lung cancer, asthma, etc. [ 35 , 36 ]. When PM2.5 enters the human body’s circulation, such as the water circulation, it seriously affects the function of the kidneys and causes kidney failure in severe cases [ 37 ].…”

Section: Pm and Pm Filter Materialsmentioning

confidence: 99%

Electrospun Nanofiber Membranes for Air Filtration: A Review

et al. 2022

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Nanomaterials for air filtration have been studied by researchers for decades. Owing to the advantages of high porosity, small pore size, and good connectivity, nanofiber membranes prepared by electrospinning technology have been considered as an outstanding air-filter candidate. To satisfy the requirements of material functionalization, electrospinning can provide a simple and efficient one-step process to fabricate the complex structures of functional nanofibers such as core–sheath structures, Janus structures, and other multilayered structures. Additionally, as a nanoparticle carrier, electrospun nanofibers can easily achieve antibacterial properties, flame-retardant properties, and the adsorption properties of volatile gases, etc. These simple and effective approaches have benefited from the significate development of electrospun nanofibers for air-filtration applications. In this review, the research progress on electrospun nanofibers as air filters in recent years is summarized. The fabrication methods, filtration performances, advantages, and disadvantages of single-polymer nanofibers, multipolymer composite nanofibers, and nanoparticle-doped hybrid nanofibers are investigated. Finally, the basic principles of air filtration are concluded upon and prospects for the application of complex-structured nanofibers in the field of air filtration are proposed.

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PM2.5 aggravates NQO1-induced mucus hyper-secretion through release of neutrophil extracellular traps in an asthma model

Cited by 18 publications

References 30 publications

Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD

Oxidative Stress Promotes Corticosteroid Insensitivity in Asthma and COPD

PM2.5 Aggravated OVA-Induced Epithelial Tight Junction Disruption Through Fas Associated via Death Domain-Dependent Apoptosis in Asthmatic Mice

Electrospun Nanofiber Membranes for Air Filtration: A Review

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