Aim: To elucidate the transcriptional characteristics of COVID-19. Materials & methods: We utilized an integrative approach to comprehensively analyze the transcriptional features of both COVID-19 patients and SARS-CoV-2 infected cells. Results: Widespread infiltration of immune cells was observed. We identified 233 genes that were codifferentially expressed in both bronchoalveolar lavage fluid and lung samples of COVID-19 patients. Functional analysis suggested upregulated genes were related to immune response such as neutrophil activation and antivirus response, while downregulated genes were associated with cell adhesion. Finally, we identified LCN2, STAT1 and UBE2L6 as core genes during SARS-CoV-2 infection. Conclusion: The identification of core genes involved in COVID-19 can provide us with more insights into the molecular features of COVID-19.
This paper considers the long-time behavior for a system of coupled wave equations of higher-order Kirchhoff type with strong damping terms. Using the Hadamard graph transformation method, we obtain the existence of the inertial manifold while such equations satisfy the spectral interval condition.
This paper investigates the dynamics for a class of nonlinear higher-order coupled Kirchhoff equations with strong linear damping. By means of the method proposed by Eden et al., the Lipschitz continuity and the discrete squeezing property of its solution semigroup are proved, and thus the existence of the exponential attractor is obtained.Keywords: higher-order Kirchhoff-type, Lipschitz continuity, discrete squeezing property, exponential attractor Ma, Q. Z and her students considered the existence of exponential attractor with method proposed by Eden et al. Through
In this paper, we investigate the finite dimensions of the global attractor for nonlinear higher-order coupled Kirchhoff type equations with strong linear damping in Hilbert spaces 0 E and 1 E. Under the appropriate assumptions, we acquire a precise estimate of the upper bound for its Hausdorff and Fractal dimensions.
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