PM-94128, a New Isocoumarin Antitumor Agent Produced by a Marine Bacterium.

Cañedo, Librada M.; Puentes, José L. Fernández; Baz, Julia Pérez; Acebal, C.; Calle, Fernando de la; Gravalos, D. G.; Quesada, T. Garcia De

doi:10.7164/antibiotics.50.175

Cited by 54 publications

(27 citation statements)

References 9 publications

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“…1) of the dihydroisocoumarin with a hydroxy amino acid side chain have attention from synthetic chemists, and there are a number of total syntheses and synthetic approaches, represented by Cappiello et al [11] and references cited therein. The structurally related antibiotics with different hydroxy amino acid side chains, baciphelacin [12], Y-05460M-A [13], PM-94128 [14], xenocoumacins [15], and Sg17-1-4 [16], all with significant activities, represent a growing number of antibiotics in this class.…”

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confidence: 99%

Isolation of 8′-Phosphate Ester Derivatives of Amicoumacins: Structure-activity Relationship of Hydroxy Amino Acid Moiety

et al. 2007

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Two new compounds, 8Ј-phospho derivatives of amicoumacins A and B, were isolated from the culture broth of a strain of Bacillus pumilus together with amicoumacins A and B. Their structures were elucidated on the basis of spectroscopic methods and alkaline phosphatase treatments. Comparison of the antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA) of these compounds suggested that C-8Ј hydroxyl and C-12Ј amide group of amicoumacin A played a critical role for anti-MRSA activity.

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Isolation of 8′-Phosphate Ester Derivatives of Amicoumacins: Structure-activity Relationship of Hydroxy Amino Acid Moiety

et al. 2007

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“…Isocoumarins belong to an important class of secondary metabolites that display a diverse biological activities 1 such as antifungal, 2 antimicrobial, 3 antitumor, 4 anti-inflammatory, 5 antiallergic, 6 antimalarial 7 and antioxidant 8 effects. A wide range of isocoumarins have been obtained from various natural sources because of their remarkable bioactivities continue to attract and stimulate interest in many research areas.…”

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confidence: 99%

Bireticulol, a bioactive isocoumarin dimer from Streptomyces sp. BCC24731

et al. 2011

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A new dimeric isocoumarin, bireticulol, was isolated from the terrestrial Streptomyces sp. and characterized as a 5-5¢ dimer of reticulol. In addition, reticulol and 8-hydroxy-6,7-dimethoxy-3-methyl isocoumarin, together with other known polyketides piericidin A, 2¢-(2-hydroxyphenyl)-2,4¢-bibenzoxazole-4-carboxylic acid methyl ester (UK-1) and 3-benzyl-4-hydroxy-5-methyldihydrofuran-2-one were also obtained. Bireticulol exhibited cytotoxic effects against KB (human epidermoid carcinoma, ATCC CCL-17) and NCI-H187 (human small cell lung cancer, ATCC CRL-5804) cell lines with IC 50 values of 24.4 and 8.31 lg ml À1 , respectively.

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“…12 Baciphelacins 8 have good potential for the treatment of bacterial and viral infections. 13,14 Among dihydroisocoumarins, PM-94128 9 15 and Y-05460M-A 10 16 have been found to exhibit antiulcer activity in addition to antibacterial and antitumor activities ( Figure 2). …”

Section: Pharmacological Importancementioning

confidence: 99%

Isocoumarins and 3,4-dihydroisocoumarins, amazing natural products: a review

Saddiqa¹,

Çakmak²,

Usman³

2017

Turk J Chem

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Abstract:The isocoumarins are naturally occurring lactones that constitute an important class of natural products exhibiting an array of biological activities. A wide variety of these lactones have been isolated from natural sources and, due to their remarkable bioactivities and structural diversity, great attention has been focused on their synthesis. This review article focuses on their structural diversity, biological applications, and commonly used synthetic modes.

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PM-94128, a New Isocoumarin Antitumor Agent Produced by a Marine Bacterium.

Cited by 54 publications

References 9 publications

Isolation of 8′-Phosphate Ester Derivatives of Amicoumacins: Structure-activity Relationship of Hydroxy Amino Acid Moiety

Isolation of 8′-Phosphate Ester Derivatives of Amicoumacins: Structure-activity Relationship of Hydroxy Amino Acid Moiety

Bireticulol, a bioactive isocoumarin dimer from Streptomyces sp. BCC24731

Isocoumarins and 3,4-dihydroisocoumarins, amazing natural products: a review

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