Pluronic® F127 Thermoresponsive Viscum album Hydrogel: Physicochemical Features and Cellular In Vitro Evaluation

Rocha, Mariana Souza; Batista, João Vitor da Costa; Melo, Michelle Nonato de Oliveira; Campos, Vânia Emerich Bucco; Toledo, Anna Lecticia Martinez Martinez; Oliveira, Adriana Passos; Picciani, Paulo H. S.; Baumgartner, Stephan; Holandino, Carla

doi:10.3390/pharmaceutics14122775

Cited by 6 publications

(1 citation statement)

References 66 publications

(132 reference statements)

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“…If we assume that the V. album extracts display their action as a phytocomplex, wherein besides the microProteins such as viscotoxins and viscolectins, many other constituents can take part in the main property, including antioxidant, anti-inflammatory and anti-stress activity, this contributes to the general actions in restoring or maintaining homeostasis. The immunoadjuvanten and immunomodulatory properties fully confirm the capacities of V. album , in accordance with the ancient ethnobotanical indications and as in line with modern medical approaches [ 209 , 210 , 211 , 212 , 213 , 214 , 215 , 216 ].…”

Section: Discussionsupporting

confidence: 79%

The Anti-Inflammatory Activity of Viscum album

Nicoletti

2023

Plants

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The therapeutic story of European mistletoe (Viscum album L.) presents a seesawing profile. In ancient times, this hemiparasitic plant was considered a panacea and even to be endowed with exceptional beneficial properties. In more recent times, despite its multiple uses in traditional medicines, some parts of the plant, in particular the berries, were considered poisonous and dangerous, including concerns of cytotoxicity, which spread serious suspicion on its medicinal utility. However, since the last century, medical interest in mistletoe has come back in force due to its utilization in clinical cancer treatments, based on its selective action on tumor cells. In Central Europe, the hydro-alcoholic extracts of European mistletoe register a relevant and continuous utilization in anthroposophic medicine, which is a holistic system that includes the utilization of phytomedicinal substances. In Switzerland and Germany, most physicians and patients use these products as complementary therapy in oncological treatments. However, despite its increasing use in this field, the results of mistletoe’s use are not always convincing, and other aspects have appeared. Nowadays, products that contain mistletoe are utilized in several fields, including diet, phytotherapy, veterinary medicine and homeopathy, but in particular in cancer therapies as coadjuvant factors, in consideration of several positive effects including effects in the improvement of quality-of-life conditions and reinforcement of the immune system. In this review, based on the understanding of the association between cancer and inflammation, we propose a relationship between these recent uses of mistletoe, based on its antioxidant properties, which are supported by phytochemical and pharmacological data. The unicity of mistletoe metabolism, which is a direct consequence of its hemiparasitism, is utilized as a key interpretation element to explain its biological properties and steer its consequent therapeutic uses.

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Section: Discussionsupporting

confidence: 79%

The Anti-Inflammatory Activity of Viscum album

Nicoletti

2023

Plants

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Nanofiber Peptides for Bacterial Trapping: A Novel Approach to Antibiotic Alternatives in Wound Infections

Yang,

Wang,

Wang

et al. 2024

Adv Healthcare Materials

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The pervasive employment of antibiotics has engendered the advent of drug‐resistant bacteria, imperiling the well‐being and health of both humans and animals. Infections precipitated by such multi‐resistant bacteria, especially those induced by methicillin‐resistant Staphylococcus aureus, pervade hospital settings, constituting a grave menace to patient vitality. Antimicrobial peptides have garnered considerable attention as a potent countermeasure against multi‐drug resistant bacteria. In preceding research endeavors, we identified an insect‐derived antimicrobial peptide that, while possessing antimicrobial attributes, manifested suboptimal efficacy against drug‐resistant gram‐positive bacteria. To ameliorate this issue, we enhanced the antimicrobial capabilities of the initial β‐hairpin AMPs by substituting the structural sequence of the original AMPs with variant lengths of hydrophobic amino acid‐hydrophilic amino acid repeat units. Throughout this endeavor, we have identified a number of peptides that possess highly effective antibacterial characteristics against a wide range of bacteria. Additionally, some of these peptides have the ability to self‐assemble into nanofibers, which then build networks in a distinctive manner to capture bacteria. Consequently, they represent prospective antibiotic alternatives for addressing wound infections engendered by drug‐resistant bacteria.This article is protected by copyright. All rights reserved

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