Injectable, self-healable and antibacterial multi-responsive tunicate cellulose nanocrystals strengthened supramolecular hydrogels for wound dressings

Liu, Xiaonan; Zhang, Yujie; Liu, Yijie; Hua, Shengming; Meng, Fanjun; Ma, Qinglin; Kong, Lingming; Pan, Selina; Che, Yuju

doi:10.1016/j.ijbiomac.2023.124365

Cited by 19 publications

(5 citation statements)

References 62 publications

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“…6B). 155 As a multi-responsive delivery platform for curcumin, this supramolecular hydrogel can release curcumin on demand in response to low pH and high-temperature environments at the wound site, as well as external UV irradiation, thereby effectively promoting wound healing. However, current research on CD-based multi-stimulus-responsive hydrogels is still in its early stages and requires further development.…”

Section: Drug Loading and Release Of Cd-based Supramolecular Hydrogelsmentioning

confidence: 99%

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Zhao,

Zheng,

et al. 2024

J. Mater. Chem. B

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Section: Drug Loading and Release Of Cd-based Supramolecular Hydrogelsmentioning

confidence: 99%

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Zhao,

Zheng,

et al. 2024

J. Mater. Chem. B

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“…For example, light energy can be used as a polymerization initiator [ 27 ], thereby controlling the mechanical strength of the gel and improving stability [ 28 ]. In addition, light can act as a switch for photothermal and photodynamic reactions to achieve wound shape adaptation, drug release, and antimicrobial effects by generating thermal and reactive oxygen radicals [ 29 , 30 , 31 ]. In addition, damage to the skin induces an endogenous electric field (EF), and previous studies have shown that electrical stimulation has a strong influence on the adhesion, migration, and proliferation of fibroblasts and endothelial cells [ 32 , 33 ].…”

Section: Chronic Wound Characteristics and Hydrogel Designmentioning

confidence: 99%

“…Similarly, tunicate cellulose nanocrystals (TCNCs) can be isolated from the mantle of marine animals, and polydopamine (PDA)-coated TCNCs have been used as the reinforcing agent of QCS. Crucially, the quinone group of PDA can interact with the amino group of QCS to form a Schiff base [ 30 ]. To achieve better mechanical properties, Hu et al designed a double-crosslinked hydrogel.…”

Section: Smart Responsive Hydrogel Designmentioning

confidence: 99%

“…In one example, Pluronic F127 containing azo groups was prepared, and cyclodextrin (CD) was used to modify QCS because of the inherent photosensitivity of CDs to azo groups. Under 365 nm UV irradiation, micelles loaded with curcumin were released from the hydrogel, yielding antibacterial effects and encouraging wound healing [ 30 ]. In another example, on NIR-II light irradiation (1064 nm), the shell of liposomes burst to release an encapsulated drug, thus enhancing the PTT effect for synergistic bacterial elimination [ 116 ].…”

Section: Smart Responsive Hydrogel Designmentioning

confidence: 99%

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Smart Responsive and Controlled-Release Hydrogels for Chronic Wound Treatment

Jia,

Dou,

Zhang

et al. 2023

Pharmaceutics

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Chronic wounds are a major health challenge that require new treatment strategies. Hydrogels are promising drug delivery systems for chronic wound healing because of their biocompatibility, hydration, and flexibility. However, conventional hydrogels cannot adapt to the dynamic and complex wound environment, which involves low pH, high levels of reactive oxygen species, and specific enzyme expression. Therefore, smart responsive hydrogels that can sense and respond to these stimuli are needed. Crucially, smart responsive hydrogels can modulate drug release and eliminate pathological factors by changing their properties or structures in response to internal or external stimuli, such as pH, enzymes, light, and electricity. These stimuli can also be used to trigger antibacterial responses, angiogenesis, and cell proliferation to enhance wound healing. In this review, we introduce the synthesis and principles of smart responsive hydrogels, describe their design and applications for chronic wound healing, and discuss their future development directions. We hope that this review will inspire the development of smart responsive hydrogels for chronic wound healing.

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“…Indeed, insufficient adhesion and complex synthesis methods make it difficult to adapt to the complex environment of wounds [19,23,24]. Therefore, an inherently antibacterial hydrogel developed using a green Polymers 2024, 16, 1316 2 of 14 and simple synthesis method with excellent antibacterial properties, biocompatibility and multifunctional properties has good potential applications [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

An Injectable, Self-Healing, Adhesive Multifunctional Hydrogel Promotes Bacteria-Infected Wound Healing

Zhang,

Wang,

Yang

et al. 2024

Polymers

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Bacterial infections have a serious impact on public health. It is urgent to develop antibacterial hydrogels with good biocompatibility to reduce the use of antibiotics. In this study, poly(lipoic acid-co-sodium lipoate)–phytic acid (P(LA-SL)-PA) hydrogels are prepared by a simple mixture of the natural small molecules lipoic acid (LA) and phytic acid (PA) in a mild and green reaction environment. The crosslinking network is constructed through the connection of covalent disulfide bonds as well as the hydrogen bonds, which endow the injectable and self-healing properties. The P(LA-SL)-PA hydrogels exhibit an adjustable compression modulus and adhesion. The in vitro agar plates assay indicates that the antibacterial rate of hydrogels against Escherichia coli and Staphylococcus aureus is close to 95%. In the rat-infected wound model, the P(LA-SL)-PA hydrogels adhere closely to the tissue and promote epithelialization and collagen deposition with a significant effect on wound healing. These results prove that the P(LA-SL)-PA hydrogels could act as effective wound dressings for promoting the healing of infected wounds.

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Injectable, self-healable and antibacterial multi-responsive tunicate cellulose nanocrystals strengthened supramolecular hydrogels for wound dressings

Cited by 19 publications

References 62 publications

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

Smart Responsive and Controlled-Release Hydrogels for Chronic Wound Treatment

An Injectable, Self-Healing, Adhesive Multifunctional Hydrogel Promotes Bacteria-Infected Wound Healing

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