Plumula Nelumbinis: A review of traditional uses, phytochemistry, pharmacology, pharmacokinetics and safety

Chen, Sixuan; Li, Xuping; Wu, Junxuan; Li, Jingyan; Xiao, Mingzhu; Yang, Ying; Liu, Zhongqiu; Cheng, Yuanyuan

doi:10.1016/j.jep.2020.113429

Cited by 41 publications

(36 citation statements)

References 83 publications

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“…In addition, many studies show its protective effects in human health in the prevention of diabetes, neurotic, obesity and cancer [3]. Lotus flowers are collected on a large scale because they contain alkaloids, flavonoids, steroids and polysaccharides [2,4]. Lotus roots and seeds are regarded as a popular nutritious source of food, since they provide β-sitosterol, palmitic acid and glucose [5].…”

Section: Introductionmentioning

confidence: 99%

Facile preparation of lotus seedpod-derived magnetic porous carbon for catalytic oxidation of Ponceau 4R

Nguyen

et al. 2021

IOP Conf. Ser.: Earth Environ. Sci.

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In this research, magnetic porous carbon was directly synthesized through one-step pyrolysis of FeCl3 – lotus seedpod mixture. Properties of the obtained material were analysed by X-ray powder diffraction, SEM image, nitrogen adsorption isotherm and vibrating sample magnetometer. The results showed that magnetic Fe3O4 particles were successfully formed over material template in 1 hour. The magnetic porous carbon possessed the specific magnetization of 7.13 emu/g, high specific surface area of 288 m2/g and total pore volume of 0.18 cm3/g. The material was subsequently applied as a potential catalyst for Ponceau 4R degradation by H2O2. Parameters including pH, H2O2 concentration, and different types of catalysts were investigated. At pH 3, 200 ppm H2O2, and 0.40 g/L magnetic porous carbon, 83% Ponceau 4R 50 ppm was removed after 120 minutes treatment. Moreover, the catalyst powders were separated from the treated mixture easily by a magnet. Summarily, magnetic porous carbon can promise to be an efficient catalyst in decomposition of Ponceau 4R.

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Section: Introductionmentioning

confidence: 99%

Facile preparation of lotus seedpod-derived magnetic porous carbon for catalytic oxidation of Ponceau 4R

Nguyen

et al. 2021

IOP Conf. Ser.: Earth Environ. Sci.

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“…The active ingredients of Plumula Nelumbinis were obtained from the TCMSP database (Traditional Chinese Medicine Systems Pharmacology and Analysis Platform, https://old.tcmsp-e.com/tcmsp.php) 34 and related literature 12,35 by using search terms such as "Plumula Nelumbinis" or "Hindu Lotus Plumule". The chemical information (such as PubChem CID, 3D conformer, and canonical SMILES) and pharmacokinetic parameters of these active ingredients were collected from the PubChem (https://pubchem.ncbi.nlm.nih.gov/) and SwissADME (http://www.swissadme.ch/) database.…”

Section: Identi Cation Of the Main Active Ingredient Of Plumula Nelumbinismentioning

confidence: 99%

“…Plumula Nelumbinis, a TCM derived from the dried young leaves and radicles of the mature seeds of the water lily plant Nelumbo nucifera Gaertn, could be used for medicine and food. It has multiple pharmacological activities such as cardiovascular protection, anti-oxidation, anti-in ammatory, and antitumor 12 . Recent studies have shown that alkaloids from Plumula Nelumbinis could attenuate vascular remodeling in spontaneously hypertensive rats 13,14 .…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Therapeutic Role of Selected Active Compounds in Plumula Nelumbinis on Pulmonary Hypertension via Network Pharmacology and Experimental Analysis

Xiao

Luo

et al. 2022

Preprint

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Excessive proliferation of pulmonary artery smooth muscle cells (PASMCs) is one of the most critical factors leading to vascular remodeling in pulmonary hypertension (PH). This study aimed to explore the effect and potential mechanism of Plumula Nelumbinis on PH by using network pharmacology and experimental analysis. The potential active components of Plumula Nelumbinis and their targets were obtained from TCMSP and PharmMapper databases. The PH-related targets were obtained from GeneCards, OMIM, DisGeNET, and TTD databases. Co-targets between Plumula Nelumbinis and PH were obtained by drawing Venn diagrams. The protein-protein interaction networks and compound-target-pathway networks were established using the STRING database and Cytoscape software. Moreover, the binding activities of core targets and essential active compounds were further validated by molecular docking. Finally, we further confirmed in vitro experiments that the main active components of Plumula Nelumbinis could inhibit the proliferation of PASMCs induced by hypoxia, as well as the increased expression of p-SRC and PIM1. Based on these observations, we conclude that multi-components (neferine, liensinine, and isoliensinine) in Plumula Nelumbinis can inhibit the hypoxia-induced proliferation of PASMCs by regulating the expression of p-SRC and PIM1, thereby delaying the development of PH.

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“…It is commonly used in several counties around the world. In TCM, Lian-Zi-Xin has been used to clear heart heat, calm the mind, and treat high fever, promote astringent essence and hemostasis [75,76]. As Qiuzhe Li reported in 2015, the total flavonoids from Lotus plumule showed noticeable anti-diabetic effects by reducing the blood glucose level, regulating blood lipid levels and improving the glucose tolerance in the T2DM mice.…”

Section: Flavonoidsmentioning

confidence: 99%

“…For example, neferine could reduce the levels of blood glu-cose, improve insulin resistance and regulate the disorder of lipid metabolism in T2DM rats [75]. Isoliensinine was found to attenuate T2DM with hyperlipidemia in a KK-Ay mouse model by regulating GLUT4, SREBP-1c, PPARγ, AMPK and ACC phosphorylation [76]. However, there are few studies on the effects of alkaloids treating T2DM through gut microbiota regulation.…”

Section: Alkaloidsmentioning

confidence: 99%

Natural Ingredients from Medicine Food Homology as Chemopreventive Reagents against Type 2 Diabetes Mellitus by Modulating Gut Microbiota Homoeostasis

Xia

Xiao

2021

Molecules

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Type 2 diabetes mellitus (T2DM) is a noteworthy worldwide public health problem. It represents a complex metabolic disorder, mainly characterized as hyperglycemia and lipid dysfunction. The gut microbiota dysbiosis has been proposed to play a role in the development of diabetes. Recently, there has been considerable interest in the use of medicine food homology (MFH) and functional food herbs (FF) to ameliorate diabetes and lead to a natural and healthy life. Hence, this review compiles some reports and findings to demonstrate that the practical use of the MFH/FF can modulate the homoeostasis of gut microbiota, thereby ameliorating the development of T2DM. The results provided useful data to support further investigation of the functional basis and application of MFH/FF to treat T2DM through maintaining intestinal homeostasis.

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Plumula Nelumbinis: A review of traditional uses, phytochemistry, pharmacology, pharmacokinetics and safety

Cited by 41 publications

References 83 publications

Facile preparation of lotus seedpod-derived magnetic porous carbon for catalytic oxidation of Ponceau 4R

Facile preparation of lotus seedpod-derived magnetic porous carbon for catalytic oxidation of Ponceau 4R

Evaluating the Therapeutic Role of Selected Active Compounds in Plumula Nelumbinis on Pulmonary Hypertension via Network Pharmacology and Experimental Analysis

Natural Ingredients from Medicine Food Homology as Chemopreventive Reagents against Type 2 Diabetes Mellitus by Modulating Gut Microbiota Homoeostasis

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