“…At various times the view has been advanced that the production of lymphocytes in large numbers is more apparent than real and that, in fact, the majority of the lymphocytes are continuously recirculating between the blood stream, 011 the one hand, and the lymph vessels and lymphoid tissues on the other. Sjovall (1936), who first clearly formulated the concept of a circulation of lymphocytes, thought that they absorbed toxins (both endogenous and exogenous) while in the tissues, and then returned them to the lymphoid tissues where these toxins would be neutralized. Lymphocytes freed of toxins could then re-enter the blood to start the cycle of toxin-fixation once again.…”