PLGA–PEG terpolymers as a carriers of bioactive agents, influence of PEG blocks content on degradation and release of herbicides into soil

Rychter, Piotr; Lewicka, Kamila; Pastusiak, Małgorzata; Domański, Marian; Dobrzyński, P.

doi:10.1016/j.polymdegradstab.2019.01.002

Cited by 24 publications

(24 citation statements)

References 36 publications

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“…The lack of modification of dextrin or maltodextrin causes the formation of the immiscible blends. The obtained DSC thermograms of the blends (Figure 3 and Supporting Information, Figure S5) were substantially similar to the previously published thermograms of PLAGA-block-PEG terpolymers [23]. However, the blends present a slightly lower glass transition temperature, which depends on the composition and ranged from 15 • C to 22 • C for blends of grafted dextrin and from 20 • C to 24 • C for blends containing grafted maltodextrin.…”

Section: Properties Of Plaga-block-peg/dextrin-graft-pcl and Plaga-blsupporting

confidence: 86%

“…The final contain of PEG in terpolymer was 10 wt %, glycolidyl-12 wt % and L-lactidyl about 78 wt %. The average molecular weight of the obtained terpolymer was about 60,000 g/mol with molecular dispersion Mw/Mn = 2.8 The detailed course of the synthesis and its conditions are described in our earlier publication [23], where also shown the usefulness of the terpolymer as a matrix used in long-term controlled release of herbicides into soil.…”

Section: Synthesis Of L-lactide/glycolide/peg Terpolymers (Plaga-peg)mentioning

confidence: 99%

“…The second component of the produced blends was a terpolymer of lactide, glycolide, and PEG. Based on our earlier studies, the terpolymer was selected as an especially useful, good material to formulate biodegradable matrices for application in the release of biologically active compounds to the soil [23]. In the present study, copolymers of dextrin with Rd = 70 wt % and 31 wt % and maltodextrin of Rd = 38 wt % and 20 wt % were selected for application.…”

Section: Properties Of Plaga-block-peg/dextrin-graft-pcl and Plaga-blmentioning

confidence: 99%

“…Similar polysaccharide-dextran was grafted with polycaprolactone [22]. We previously investigated a blocked terpolymer with a chain composed of two blocks, namely L-lactide/glycolide copolymer block and polyethylene glycol (PEG) block [23], where we demonstrated the effect of comparatively small content of PEG blocks on strong acceleration of degradation in activated sludge or in soil. Moreover, we demonstrated the usefulness of these terpolymers as a biodegradable carrier for the controlled release of selected pesticides.…”

Section: Introductionmentioning

confidence: 99%

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Biodegradable Blends of Grafted Dextrin with PLGA-block-PEG Copolymer as a Carrier for Controlled Release of Herbicides into Soil

et al. 2020

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The presented work aimed to test influence of poly(L-lactide-co-glycolide)-block-poly (ethylene oxide) copolymer modification by blending with grafted dextrin or maltodextrin on the course of degradation in soil and the usefulness of such material as a matrix in the controlled release of herbicides. The modification should be to obtain homogenous blends with better susceptibility to enzymatic degradation. Among all tested blends, which were proposed as a carrier for potential use in the controlled release of plant protection agents, PLGA-block-PEG copolymer blended with grafted dextrin yielded very promising results for their future applications, and what is very importantly proposed formulations provide herbicides in unchanged form into soil within few months of release. The modification PLAGA/PEG copolymer by blending with modificated dextrins affects the improvement of the release profile. The weekly release rates for both selected herbicides (metazachlor and pendimethalin) were constant for a period of 12 weeks. Enzymatic degradation of modified dextrin combined with leaching of the degradation products into medium caused significant erosion of the polymer matrix, thereby leading to acceleration of water diffusion into the polymer matrix and allowing for easier leaching of herbicides outside the matrix.

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Section: Properties Of Plaga-block-peg/dextrin-graft-pcl and Plaga-blsupporting

confidence: 86%

Section: Synthesis Of L-lactide/glycolide/peg Terpolymers (Plaga-peg)mentioning

confidence: 99%

Section: Properties Of Plaga-block-peg/dextrin-graft-pcl and Plaga-blmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biodegradable Blends of Grafted Dextrin with PLGA-block-PEG Copolymer as a Carrier for Controlled Release of Herbicides into Soil

et al. 2020

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“…Main signals are derived from the carbons of succinate (signal a) and citrate units (signals e and h) as well as lactidyl (LLLL) and additionally glycolide (GGGG or GGLL). Only the carbon signal LLLL was clearly split, as well as the signal associated with the presence of glycolidyl units (GGGG and GGLL signals), analogically as it was the case of poly(l-lactide-co-glycolide) or poly(lactide-co-glycolide)-block-poly(ethylene glycol) copolymers [18,23]. The absence of additional signals that could be derived from shorter chain sequences suggests that the chains of received copolymers have a block chain structure.…”

Section: Synthesis and Characterization Of Poly (L-lactide-co-glycolimentioning

confidence: 91%

Synthesis and Properties of Bioresorbable Block Copolymers of l-Lactide, Glycolide, Butyl Succinate and Butyl Citrate

et al. 2020

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The paper presents the course of synthesis and properties of a series of block copolymers intended for biomedical applications, mainly as a material for forming scaffolds for tissue engineering. These materials were obtained in the polymerization of l-lactide and copolymerization of l-lactide with glycolide carried out using a number of macroinitiators previously obtained in the reaction of polytransesterification of succinic diester, citric triester and 1,4-butanediol. NMR, FTIR and DSC were used to characterize the materials obtained; wettability and surface free energy were assessed too. Moreover, biological tests, i.e., viability and metabolic activity of MG-63 osteoblast-like cells in contact with synthesized polymers were performed. Properties of obtained block copolymers were controlled by the composition of the polymerization mixture and by the composition of the macroinitiator. The copolymers contained active side hydroxyl groups derived from citrate units present in the polymer chain. During the polymerization of l-lactide in the presence of polyesters with butylene citrate units in the chain, obtained products of the reaction held a fraction of highly branched copolymers with ultrahigh molecular weight. The reason for this observed phenomenon was strong intermolecular transesterification directed to lactidyl side chains, formed as a result of chain growth on hydroxyl groups related to the quaternary carbons of the citrate units. Based on the physicochemical properties and results of biological tests it was found that the most promising materials for scaffolds formation were poly(l-lactide–co–glycolide)–block–poly(butylene succinate–co–butylene citrate)s, especially those copolymers containing more than 60 mol % of lactidyl units.

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Use Nanotools for Weed Control and Exploration of Weed Plants in Nanotechnology

Balah

Pudake

2019

Nanoscience for Sustainable Agriculture

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PLGA–PEG terpolymers as a carriers of bioactive agents, influence of PEG blocks content on degradation and release of herbicides into soil

Cited by 24 publications

References 36 publications

Biodegradable Blends of Grafted Dextrin with PLGA-block-PEG Copolymer as a Carrier for Controlled Release of Herbicides into Soil

Biodegradable Blends of Grafted Dextrin with PLGA-block-PEG Copolymer as a Carrier for Controlled Release of Herbicides into Soil

Synthesis and Properties of Bioresorbable Block Copolymers of l-Lactide, Glycolide, Butyl Succinate and Butyl Citrate

Use Nanotools for Weed Control and Exploration of Weed Plants in Nanotechnology

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