PLGA-PEG-PLGA Tri-Block Copolymers as In Situ Gel-Forming Peptide Delivery System: Effect of Formulation Properties on Peptide Release

Ghahremankhani, Ali Afshar; Dorkoosh, Farid Abedin; Dinarvand, Rassoul

doi:10.1080/10837450701702842

Cited by 63 publications

(22 citation statements)

References 16 publications

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“…First, 60 g of PEG 1000 were heated at 150°C and stirred (250 rpm) in a stainless steel reactor under a vacuum (5 mmHg) for 3 h. Next, 113.46 g of D,L-lactide and 30.48 g of glycolide were added, and the mixture was heated and stirred at 150°C under a vacuum for 30 min. As a catalyst, 0.04 g of stannous 2-ethylhexanoate was added, and the heating and stirring was continued at 160 ± 5°C under a vacuum for 8 h [19].…”

Section: Methodsmentioning

confidence: 99%

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Preparation and analysis of a sustained drug delivery system by PLGA–PEG–PLGA triblock copolymers

et al. 2012

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Traditional drug delivery systems that are based on multiple dosing are usually accompanied by many shortcomings, including unwanted fluctuations in the plasma concentration of the drug and poor patient compliance. In this study, we aimed to synthesize a polymeric drug delivery system based on a triblock copolymer of PLGA-PEG1000-PLGA and investigate its application as a controlled drug delivery system. Naltrexone hydrochloride and vitamin B12 were used as model drugs here. The copolymer was successfully synthesized by the ring-opening method. A phase transition analysis indicated that the copolymer is in gel at body temperature. The release profiles from the formulations showed a higher initial release followed by a slower pattern for up to 4 weeks. More than 50 % of the vitamin B12 and 60 % of the naltrexone hydrochloride were released during this period.

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Section: Methodsmentioning

confidence: 99%

“…The eluent was tetrahydrofuran with a flow rate of 1 mL/min. Polystyrene standards were used as a calibration agent [7,19]. The sol-gel transition temperature was determined by a refrigerated bath circulator instrument (WISD P-22, South Korea).…”

Section: Copolymer Characterizationmentioning

confidence: 99%

Preparation and analysis of a sustained drug delivery system by PLGA–PEG–PLGA triblock copolymers

et al. 2012

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“…Gelation time did not affect the drug release profile of the system and the diffusion was the main mechanism for Calcitonin release from these systems [86]. Besides, calcitonin release kinetics, from a PLGA-PEG-PLGA polymeric solutions (25% w/w), could be controlled by using different excipients such as, for example, sodium lauryl sulfate that showed to reduce drug release rate from the systems [87].…”

Section: Pharmaceutical Applicationmentioning

confidence: 99%

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

et al. 2011

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Self-assembling block copolymers (poloxamers, PEG/PLA and PEG/PLGA diblock and triblock copolymers, PEG/polycaprolactone, polyether modified poly(Acrylic Acid)) with large solubility difference between hydrophilic and hydrophobic moieties have the property of forming temperature dependent micellar aggregates and, after a further temperature increase, of gellifying due to micelle aggregation or packing. This property enables drugs to be mixed in the sol state at room temperature then the solution can be injected into a target tissue, forming a gel depot in-situ at body temperature with the goal of providing drug release control. The presence of micellar structures that give rise to thermoreversible gels, characterized by low toxicity and mucomimetic properties, makes this delivery system capable of solubilizing water-insoluble or poorly soluble drugs and of protecting labile molecules such as proteins and peptide drugs.

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“…Some sustained-release reagents, such as liposomes, microspheres and gels, are emerging (Ahmad et al 2006;Ravivarapu et al 2000;Jain et al 2007a, b;Ghahremankhani et al 2008). With the development of sustained-release techniques and renewable drug delivery systems, interstitial chemotherapy is gradually being considered an effective approach for tumor treatment.…”

Section: Introductionmentioning

confidence: 99%

US-guided interstitial chemotherapy using paclitaxel temperature-responsive gel for breast cancer treatment in rat

Chen

Lin

Yang

et al. 2009

J Cancer Res Clin Oncol

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PLGA-PEG-PLGA Tri-Block Copolymers as In Situ Gel-Forming Peptide Delivery System: Effect of Formulation Properties on Peptide Release

Cited by 63 publications

References 16 publications

Preparation and analysis of a sustained drug delivery system by PLGA–PEG–PLGA triblock copolymers

Preparation and analysis of a sustained drug delivery system by PLGA–PEG–PLGA triblock copolymers

Thermosensitive Self-Assembling Block Copolymers as Drug Delivery Systems

US-guided interstitial chemotherapy using paclitaxel temperature-responsive gel for breast cancer treatment in rat

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