PLGA nanofibers improves the antitumoral effect of daunorubicin

Guimarães, Pedro Pires Goulart; Oliveira, Michele F.; Gomes, Alinne D. M.; Gontijo, Sávio Morato de Lacerda; Cortés, María Esperanza; Campos, Paula Peixoto; Viana, Celso Tarso Rodrigues; Andrade, Sílvia Passos; Sinisterra, Rubén D.

doi:10.1016/j.colsurfb.2015.09.005

Cited by 36 publications

(13 citation statements)

References 52 publications

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“…61 In addition, the literature described that the drug delivery from biodegradable nanofibers could happen through three stages, and each stage might be associated with different kinetic models. [61][62][63] According with Table II the results reinforced the above stated hypothesis that the Bixin release was mainly governed by the Bixin diffusion through the nanofibers to the release media instead of the PCL nanofiber biodegradation. The fibroblast are known to exhibit a phenotypic change dissemination as well as migration and proliferation in the pro-cess of wound healing in diabetic patients.…”

Section: Discussionsupporting

confidence: 68%

“…Diffusion of the drug from a polymeric matrix can occur through two mechanisms: drug diffusion out of the matrix and/or drug diffusion because of matrix degradation . In addition, the literature described that the drug delivery from biodegradable nanofibers could happen through three stages, and each stage might be associated with different kinetic models . According with Table the results reinforced the above stated hypothesis that the Bixin release was mainly governed by the Bixin diffusion through the nanofibers to the release media instead of the PCL nanofiber biodegradation.…”

Section: Discussionsupporting

confidence: 62%

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Efficient cutaneous wound healing using bixin-loaded PCL nanofibers in diabetic mice

Pinzón-García

Cassini‐Vieira

Ribeiro

et al. 2016

J. Biomed. Mater. Res.

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The present work demonstrated an efficient cutaneous wound healing using Bixin-loaded polycaprolactone (PCL) nanofibers as a controlled delivery system. The influence of Bixin (Bix) content on PCL nanofiber, Bix-PCL1(2.5% w/w bix) and Bix-PCL2 (12.5% w/w bix) formation was investigated using electrical conductivity, attenuated total reflectance infrared spectroscopy, X-ray diffraction, thermal analysis, and scanning electronic microscopy. The results showed that a greater bixin concentration resulted in higher polymeric solution electrical conductivity. Moreover, higher polymeric solution electrical conductivity provides lower nanofibers in terms of average diameter than pure PCL nanofibers. In vitro release was largely governed by a diffusion-controlled mechanism. The initial Bixin release domain showed a burst release over the first 10 hours where approximately 30% and 40% of Bixin was released from Bix-PCL1 and Bix-PCL2 nanofibers, respectively. The second kinetic domain was comprised of a continuous and slow Bixin release that led to almost 100% of the Bixin being released within 14 days. The results on excisional wound model in induced diabetic mice indicated that the low concentration of Bixin released from loaded Bix-PCL nanofibers maintain the biological activity of Bixin and is efficient in accelerating the wound healing as well as in reducing the scar tissue area compared with pure PCL nanofibers. Therefore, soft material Bixin-loaded PCL nanofibers are a promising candidate for use in wound dressing. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1938-1949, 2017.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionsupporting

confidence: 62%

Efficient cutaneous wound healing using bixin-loaded PCL nanofibers in diabetic mice

Pinzón-García

Cassini‐Vieira

Ribeiro

et al. 2016

J. Biomed. Mater. Res.

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“…According data obtained, pure PLGA and all polymeric form exhibited glass transition temperature at 43–46°C, which corresponds to the literature data . Substances revealed melting peaks at 147.75°C (AbrA) and 149.85°C (Dtx).…”

Section: Resultssupporting

confidence: 87%

Development of novel PLGA nanoparticles with co‐encapsulation of docetaxel and abiraterone acetate for a highly efficient delivery into tumor cells

et al. 2018

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Co-encapsulation of abiraterone acetate (AbrA) and docetaxel (Dtx) in polymeric nanoparticles as novel prototypes for prostate cancer treatment combining hormonal and chemotherapy was designed. Nanoparticles (NPs) composed of poly(DL-lactide-co-glycolide) (PLGA) were prepared by singleemulsion solvent evaporation technique and characterized in terms of morphology with atomic force microscopy and transmission electron microscopy. HPLC method for simultaneous determination of AbrA and Dtx encapsulation efficacy was developed. Also differential scanning calorimetry and Fouriertransform infrared spectroscopy were provided. To study the effectiveness of cellular internalization and distribution of NPs with AbrA and Dtx co-encapsulation (NP-AbrA/Dtx), a fluorescence microscopy was utilized. NPs prepared had size 256.3 AE9.4 nm and zeta potential −18.4 AE1.4 mV. Encapsulation efficacy for AbrA was 68.7% and for Dtx was 74.3%. NPs were able to control the AbrA and Dtx release within 24 h. The mathematical model of drug release was performed. The results obtained from confocal microscopy showed the effective accumulation of the NP-AbrA/Dtx in the cytoplasm of cells. Synthesized NPs possessed satisfactory parameters and a biphasic release profile, proceeding by the Fick diffusion mechanism, which provide prolonged release of the drugs and maintenance of their concentration. It was shown that NPs loaded with AbrA and Dtx exhibited a high cytotoxic activity on the LNCaP cell line, similar to the combination of free drugs of AbrA and Dtx, but in contrast to the combination of substances, had a synergistic mechanism of action. Our findings support the potential use of developed NPs in further in vivo studies.How to cite this article: Sokol MB, Nikolskaya ED, Yabbarov NG, Zenin VA, Faustova MR, Belov AV, Zhunina OA, Mollaev MD, Zabolotsky AI, Tereshchenko OG, Severin ES. 2019. Development of novel PLGA nanoparticles with co-encapsulation of docetaxel and abiraterone acetate for a highly efficient delivery into tumor cells. J Biomed Mater Res Part B 2019:107B:1150-1158.

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“…Nowadays, electrospinning is one of the most cost-effective methods for producing nonwoven nanofibrous mats from various polymers including chitosan (CS) [7], chitosan-gelatin [8], poly(lactic-co-glycolide) [9], sodium alginate [10], poly--caprolactone [11], collagen [12] and polyurethane [13]. The nanofiber mats have important properties including small fiber size, extremely large specific surface, high porosity and low fabric weight which are favorable for drug release, absorbency, wound dressing, pharmaceuticals, cosmetics, food coating and food packaging [14].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial electrospun chitosan-polyethylene oxide nanocomposite mats containing ZIF-8 nanoparticles

Kohsari

Shariatinia‬

Pourmortazavi

2016

International Journal of Biological Macromolecules

171

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PLGA nanofibers improves the antitumoral effect of daunorubicin

Cited by 36 publications

References 52 publications

Efficient cutaneous wound healing using bixin-loaded PCL nanofibers in diabetic mice

Efficient cutaneous wound healing using bixin-loaded PCL nanofibers in diabetic mice

Development of novel PLGA nanoparticles with co‐encapsulation of docetaxel and abiraterone acetate for a highly efficient delivery into tumor cells

Antibacterial electrospun chitosan-polyethylene oxide nanocomposite mats containing ZIF-8 nanoparticles

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