PLGA–lipid liposphere as a promising platform for oral delivery of proteins

Ma, Tianzhou; Wang, Lianyan; TingyuanYang,; Wang, Dong; Ma, Guanghui; Wang, Siling

doi:10.1016/j.colsurfb.2014.02.039

Cited by 39 publications

(17 citation statements)

References 19 publications

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“…Such thermal behavior suggested that the drug was dispersed in the liposphere core, in an amorphous state, which explained the sustained drug release, as well as the increase in photostability achieved [106]. In another study, Ma et al [107] developed a biohybrid system based on PLGA copolymer conjugated with the liposphere core for the delivery BSA for oral administration. The lipospheres exhibited spherical morphology with PLGA hydrophobic core delimited by a weak ring, suggesting that the lipid layer was on its surface, as shown by scanning electron microscopy.…”

Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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The use of biomaterials composed of organic pristine components has been successfully described in several purposes, such as tissue engineering and drug delivery. Drug delivery systems (DDS) have shown several advantages over traditional drug therapy, such as greater therapeutic efficacy, prolonged delivery profile, and reduced drug toxicity, as evidenced by in vitro and in vivo studies as well as clinical trials. Despite that, there is no perfect delivery carrier, and issues such as undesirable viscosity and physicochemical stability or inability to efficiently encapsulate hydrophilic/hydrophobic molecules still persist, limiting DDS applications. To overcome that, biohybrid systems, originating from the synergistic assembly of polymers and other organic materials such as proteins and lipids, have recently been described, yielding molecularly planned biohybrid systems that are able to optimize structures to easily interact with the targets. This work revised the biohybrid DDS clarifying their advantages, limitations, and future perspectives in an attempt to contribute to further research of innovative and safe biohybrid polymer-based system as biomaterials for the sustained release of active molecules.

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Section: Innovative Hybrid Lipid Nanoparticles: Solid Lipid Nanopartimentioning

confidence: 99%

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Ribeiro

Alcántara

Silva

et al. 2017

International Journal of Polymer Science

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“…In a recent study, poly lacticco-glycolic acid (PLGA)-lipid lipospheres were developed, which consisted of a PLGA lipophilic interior and a selfassembled lipophilic layer at the interface. These lipospheres demonstrated high crossing efficiency along the microfold cells (an in vivo model), resulting in the efficient improvement of the intestinal absorption for the loaded protein molecules over regular polymeric nanoparticles [130]. Another research group recently developed and formulated low molecular weight (LMW) chitosan-lipid nanoparticle composites to deliver siRNA into the cytoplasm.…”

Section: Solid Lipid Nanoparticles (Slns)mentioning

confidence: 99%

Review of recently used techniques and materials to improve the efficiency of orally administered proteins/peptides

et al. 2019

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Objectives The main objective of present review is to explore and evaluate the effectiveness of recently developed methods to improve the bioavailability of orally administered biopharmaceutical drugs. Methods A systematic search of sciencedirect, tandfonline and Google Scholar databases based on various sets of keywords was performed. All results were evaluated based on their abstracts, and irrelevant studies were neglected during further evaluation. Results At present, biopharmaceuticals are used as injectable therapies as they are not absorbed adequately from the different routes of drug administration, particularly the oral one. Their insufficient absorption is attributed to their high molecular weight, degradation by proteolytic enzymes, high hydrophilicity and rigidity of the absorptive tissues. From industrial aspect incorporation of enzyme inhibitors (EIs) and permeation enhancers (PEs) and mucoadhesive polymers into conventional dosage forms may be the easiest way of formulation of orally administered macromolecular drugs, but the effectiveness of protection and absorption enhancement here is the most questionable. Conjugation may be problematic from regulatory aspect. Encapsulation into lipid-based vesicles sufficiently protects the incorporated macromolecule and improves intestinal uptake but have considerable stability issues. In contrast, polymeric nanocarriers may provide good stability but provides lower internalization efficacy in comparison with the lipid-based carriers. Conclusion It can be concluded that the combination of the advantages of mucoadhesive polymeric and lid-based carriers in hybrid lipid/polymer nanoparticles may result in improved absorption and might represent a potential means for the oral administration of therapeutic proteins in the near future.

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“…Bovine serum albumin in another study, the challenge in the oral delivery of protein drugs is to enhance their oral BA. [40] Herein, we report the uniform-sized liposphere prepared by premix membrane emulsification combined with W1/O/W double-emulsion method as a potential oral carrier for proteins. The protein-loaded liposphere was composed of a hydrophobic poly (d, L-lactide-co-glycolide) (PLGA) core and the lipid molecules self-assembled at the interface of W1/O and O/W2.…”

Section: Rifampicin (Rmp)mentioning

confidence: 99%

Untitled

Patra¹

2018

AJP

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Solid lipid-based drug delivery systems such as lipospheres, solid lipid nanoparticles, and nanostructured lipid carriers have high stability, high carrier capacity, feasibility of incorporation of both hydrophilic and hydrophobic substances, and feasibility of variable routes of administration, including oral, topical, and parenteral and pulmonary routes. Highly lipophilic and poorly water-soluble compounds that also undergo extensive presystemic intestinal metabolism are the ultimate candidates for incorporation into solid lipid-based drug delivery systems to obtain increased and less variable bioavailability (BA). Increase in biliary and pancreatic secretions, stimulation of lymphatic transport, improvement of intestinal wall permeability, reduction of metabolism and efflux activity, and alteration in mesenteric and liver blood flow, which appreciably contribute to improved oral BA of the drug.

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PLGA–lipid liposphere as a promising platform for oral delivery of proteins

Cited by 39 publications

References 19 publications

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Advances in Hybrid Polymer-Based Materials for Sustained Drug Release

Review of recently used techniques and materials to improve the efficiency of orally administered proteins/peptides

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