2023
DOI: 10.1016/j.jddst.2023.104648
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PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry

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Cited by 4 publications
(3 citation statements)
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“…After the initial burst release in the rst 24hrs, the lag phase is noticed in the release of DEX which is approximately 12% of the total. This could be due to the hydrophobic nature of both the polymer and the drug which limits the exposure of drug to the buffer [22].…”
Section: In Vitro Drug Releasementioning
confidence: 99%
See 1 more Smart Citation
“…After the initial burst release in the rst 24hrs, the lag phase is noticed in the release of DEX which is approximately 12% of the total. This could be due to the hydrophobic nature of both the polymer and the drug which limits the exposure of drug to the buffer [22].…”
Section: In Vitro Drug Releasementioning
confidence: 99%
“…Biodegradable and controlled release implants hold signi cant promise in enhancing the therapeutic effectiveness while minimizing the unwanted side effects across various drug treatments [21]. A variety of procedures are available for the manufacturing of these implants like hot-melt extrusion, compression, melting and molding [22,23].…”
Section: Introductionmentioning
confidence: 99%
“…Other approaches focus on perforating the natural barrier of the round window membrane to directly reach the intracochlear space [11][12][13]. Related to the latter, dexamethasone-loaded poly(lactic-co-glycolic acid) (PLGA) rod-like extrudates have showcased the possibility of delivering dexamethasone through the round window membrane under in vitro conditions for up to 84 days [13,14]. Silicone microdevices featuring a tip that can be fixed at the round window membrane [12] have been tested in vitro and are shown to be capable of delivering dexamethasone to the inner ear.…”
Section: Introductionmentioning
confidence: 99%