PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry

Wachowiak, Sophie; Danède, Florence; willart, Jean-François; Siepmann, Florence; Siepmann, Juergen; Hamoudi, Mounira

doi:10.1016/j.jddst.2023.104648

Cited by 4 publications

(3 citation statements)

References 44 publications

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“…After the initial burst release in the rst 24hrs, the lag phase is noticed in the release of DEX which is approximately 12% of the total. This could be due to the hydrophobic nature of both the polymer and the drug which limits the exposure of drug to the buffer [22].…”

Section: In Vitro Drug Releasementioning

confidence: 99%

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Development of a biodegradable polymer-based implant to release dual drugs for post-operative management of cataract surgery

Subhash,

Nair,

Srinivas

et al. 2024

Drug Deliv. and Transl. Res.

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Cataract surgery is followed by post-operative eye drops for a duration of 4–6 weeks. The multitude of ocular barriers, coupled with the discomfort experienced by both the patient and their relatives in frequently administering eye drops, significantly undermines patient compliance, ultimately impeding the recovery of the patient. This study aimed to design and develop an ocular drug delivery system as an effort to achieve a drop-free post-operative care after cataract surgery. An implant was prepared containing a biodegradable polymer Poly-lactic-co-glycolic acid (PLGA), Dexamethasone (DEX) as an anti-inflammatory drug, and Moxifloxacin(MOX) as an antibiotic. Implant characterization and drug loading analysis were conducted. In vitro drug release profile showed that the release of the two drugs are correlated with the clinical prescription for post operative eye drops. In vivo study was conducted on New Zealand albino rabbits where one eye underwent cataract surgery, and the drug delivery implant was inserted into the capsular bag after placement of the synthetic intraocular lens (IOL). Borderline increase in the intraocular pressure (IOP) was noted in the test sample group. Slit-lamp observations revealed no significant anterior chamber reaction in all study groups. Histopathology study of the operated eye revealed no significant pathology in the test samples. This work aims at developing the intra ocular drug delivery implant which will replace the post-operative eye drops and help the patient with the post-operative hassle of eye drops. Graphical abstract (created using BioRender.com)

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Section: In Vitro Drug Releasementioning

confidence: 99%

“…Biodegradable and controlled release implants hold signi cant promise in enhancing the therapeutic effectiveness while minimizing the unwanted side effects across various drug treatments [21]. A variety of procedures are available for the manufacturing of these implants like hot-melt extrusion, compression, melting and molding [22,23].…”

Section: Introductionmentioning

confidence: 99%

Development of a biodegradable polymer-based implant to release dual drugs for post-operative management of cataract surgery

Subhash,

Nair,

Srinivas

et al. 2024

Drug Deliv. and Transl. Res.

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“…Other approaches focus on perforating the natural barrier of the round window membrane to directly reach the intracochlear space [11][12][13]. Related to the latter, dexamethasone-loaded poly(lactic-co-glycolic acid) (PLGA) rod-like extrudates have showcased the possibility of delivering dexamethasone through the round window membrane under in vitro conditions for up to 84 days [13,14]. Silicone microdevices featuring a tip that can be fixed at the round window membrane [12] have been tested in vitro and are shown to be capable of delivering dexamethasone to the inner ear.…”

Section: Introductionmentioning

confidence: 99%

High-Precision 3D Printing of Microporous Cochlear Implants for Personalized Local Drug Delivery

Isaakidou,

Apachitei,

Fratila-Apachitei

et al. 2023

JFB

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Hearing loss is a highly prevalent multifactorial disorder affecting 20% of the global population. Current treatments using the systemic administration of drugs are therapeutically ineffective due to the anatomy of the cochlea and the existing blood–labyrinth barrier. Local drug delivery systems can ensure therapeutic drug concentrations locally while preventing adverse effects caused by high dosages of systemically administered drugs. Here, we aimed to design, fabricate, and characterize a local drug delivery system for the human cochlea. The design was relevant to the size of the human ear, included two different shapes, and incorporated two different microporous structures acting as reservoirs for drug loading and release. The four cochlear implant designs were printed using the two-photon polymerization (2PP) technique and the IP-Q photoresist. The optimized 2PP process enabled the fabrication of the cochlear implants with great reproducibility and shape fidelity. Rectangular and cylindrical implants featuring cylindrical and tapered tips, respectively, were successfully printed. Their outer dimensions were 0.6 × 0.6 × 2.4 mm3 (L × W × H). They incorporated internal porous networks that were printed with high accuracy, yielding pore sizes of 17.88 ± 0.95 μm and 58.15 ± 1.62 μm for the designed values of 20 μm and 60 μm, respectively. The average surface roughness was 1.67 ± 0.24 μm, and the water contact angle was 72.3 ± 3.0°. A high degree of polymerization (~90%) of the IP-Q was identified after printing, and the printed material was cytocompatible with murine macrophages. The cochlear implants designed and 3D printed in this study, featuring relevant sizes for the human ear and tunable internal microporosity, represent a novel approach for personalized treatment of hearing loss through local drug delivery.

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A disulfiram/copper gluconate co-loaded bi-layered long-term drug delivery system for intraperitoneal treatment of peritoneal carcinomatosis

Wang,

Luo,

Zhang

et al. 2023

Colloids and Surfaces B: Biointerfaces

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PLGA implants for controlled dexamethasone delivery: Impact of the polymer chemistry

Cited by 4 publications

References 44 publications

Development of a biodegradable polymer-based implant to release dual drugs for post-operative management of cataract surgery

Development of a biodegradable polymer-based implant to release dual drugs for post-operative management of cataract surgery

High-Precision 3D Printing of Microporous Cochlear Implants for Personalized Local Drug Delivery

A disulfiram/copper gluconate co-loaded bi-layered long-term drug delivery system for intraperitoneal treatment of peritoneal carcinomatosis

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