A disulfiram/copper gluconate co-loaded bi-layered long-term drug delivery system for intraperitoneal treatment of peritoneal carcinomatosis

Wang, Puxiu; Luo, Qiuhua; Zhang, Ling; Qu, Xiujuan; Che, Xiaofang; Cai, Shuang; Liu, Yunpeng

doi:10.1016/j.colsurfb.2023.113558

Cited by 2 publications

(1 citation statement)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The available sustained release dosage forms can release NTX up to 28 days from micro emulsions [ 11 ] and 35 days from fluid crystal injections [ 12 ]. The sustained release effect of DSF with available dosage forms has been observed to be 24 h from nano emulsion gels in situ [ 13 ] and 14 days from thermosensitive hydrogels [ 14 ]. The chronic nature of narcotics addiction affords frequent relapse and long-term treatment is obligatory to achieve treatment goals.…”

Section: Introductionmentioning

confidence: 99%

Design and Characterization of Chitosan-Based Smart Injectable Hydrogel for Improved Sustained Release of Antinarcotics

Aftab,

Javed,

Haider

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

The treatment adherence of narcotics-addicted individuals with reduced incidences of relapse can be enhanced by a sustained drug release formulation of antinarcotics. So far, different drug formulations have been reported with sustained drug release periods of 28 and 35 days. To further enhance this duration, different formulations of injectable hydrogels (IHs) have been developed by combining low molecular weight (LMW) and high molecular weight (HMW) chitosan (CS) with guar gum (GG) and crosslinking them by sodium bi phosphate dibasic. The structural, morphological, and physicochemical properties of LMW-CS IH, and HMW-CS IH were evaluated using Fourier transform infrared spectroscopy (FT-IR), thermo-gravimetric analysis (TGA), scanning electron microscopy (SEM), and rheological, swelling, and biodegradation analysis. The HMW-CS IH showed high crosslinking, increased thermal stability, high mechanical strength, elevated swelling, and low biodegradation. The antinarcotic drugs naltrexone (NTX) and disulfiram (DSF) were loaded separately into the HMW-CS IH and LMW-CS IH. The release of NTX and DSF was investigated in phosphate buffer saline (PBS) and ethanol (0.3%, 0.4%, and 0.5%) over a 56-day period using an UV spectrophotometer. The drug release data were tested in zero-order, first-order, and Korsemeyer–Peppas mathematical models. In PBS, all prepared formulations followed non-Fickian drug release, while in ethanol, only NTX HMW-CS IH followed non-Fickian release in all three different concentrations of ethanol.

show abstract