PLGA-based nanoparticles: A new paradigm in biomedical applications

Sharma, Shweta; Parmar, Ankush; Kori, Shivpoojan; Sandhir, Rajat

doi:10.1016/j.trac.2015.06.014

Cited by 234 publications

(161 citation statements)

References 63 publications

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“…51 Various methods include emulsion-solvent evaporation (single and double emulsion), phase separation, emulsification-solvent diffusion, solvent displacement, dialysis, spray drying and self-assembly, which have been extensively applied in the successful synthesis of PLGA NPs. 52,53 The most common method used for the preparation of PLGA NPs is the emulsification-solvent evaporation technique. However, this method is primarily used for the encapsulation of hydrophobic drugs.…”

Section: Nanocarriers For Gf Encapsulation and Release For Biomedicalmentioning

confidence: 99%

Novel biomaterial strategies for controlled growth factor delivery for biomedical applications

et al. 2017

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Growth factors (GFs) are soluble proteins secreted by cells that have the ability to regulate a variety of cellular processes and tissue regeneration. However, their translation into clinical applications is limited due to their short effective half-life, low stability, and rapid inactivation by enzymes under physiological conditions. To maximize the effectiveness of GFs and their biologically relevant applicability, a wide variety of sophisticated bio-inspired systems have been developed that augment tissue repair and cellular regeneration by controlling how much, when, and where GFs are released. Recently, protein immobilization techniques combined with nanomaterial carriers have shown promise in mimicking the natural healing cascade during tissue regeneration by augmenting the delivery and effectiveness of GFs. This review evaluates the latest techniques in direct immobilization and relevant biomaterials used for GF loading and release, including synthetic polymers, albumin, polysaccharides, lipids, mesoporous silica-based nanoparticles (NPs), and polymeric capsules. Specifically, we focus on GF-encapsulated NPs in functionalized microporous scaffolds as a promising alternative with the ability to mimic extracellular matrix (ECM) hierarchical architectures and components with high cell affinity and bioactivity. Finally, we discuss how these next-generation, advanced delivery systems have been used to enhance tissue repair and regeneration and consider future implications for their use in the field of regenerative medicine.

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Section: Nanocarriers For Gf Encapsulation and Release For Biomedicalmentioning

confidence: 99%

Novel biomaterial strategies for controlled growth factor delivery for biomedical applications

et al. 2017

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“…PLGA is synthesized through random ring-opening copolymerization of two different monomers, glycolic acid (GA) and LA, in the presence of a catalyst (Sharma, Parmar, Kori, & Sandhir, 2016). A distinct advantage of PLGA over other polymers is that its properties can be tailored according to specifications of the end product via the regulation of LA/GA ratios and molecular range .…”

Section: Polylactide-co-glycolidementioning

confidence: 99%

Nanodiamond in composite: Biomedical application

Rehman

Houshyar

Wang

2020

J Biomedical Materials Res

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The biocompatibility of materials is the determining factor for them to be applied in biomedical areas. Nanodiamond (ND) has gained increasing interest in this area due to its biocompatibility, ease of surface functionalization and excellent mechanical performance. ND has been widely used to reinforce biopolymers, and the resultant biocomposites have found applications in bone tissue engineering, chemotherapeutic drug delivery, and wound healing. Fluorescent ND, when combined with biopolymers, is serving for bioimaging and sensing applications. Herein, we contribute a description of ND, recent trends in its adoption for biopolymers, functionalization methods, amalgamation techniques of ND with biopolymers, potential applications of these composites in the biomedical field and future perspectives.biocompatibility, biocomposites, biopolymers, nanodiamond, scaffold

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“…us, the development of carriers to transport and stabilize NAC inside the body is a major concern when researching for new ways to increase its bioavailability. In this scenario, nanoparticles manufactured in materials such as PLGA, a biodegradable copolymer, are being developed [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Improvement of N-Acetylcysteine Loaded in PLGA Nanoparticles by Nanoprecipitation Method

Lancheros

Guerrero

Godoy-Silva

2018

Journal of Nanotechnology

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N-Acetylcysteine (NAC) is a hydrophilic compound with a low bioavailability. It has been used as an effective antioxidant agent.is research seeks to enhance the entrapment of NAC in PLGA nanoparticles for drug delivery systems. e nanoparticles were made using the nanoprecipitation method and changing the following parameters: the solvent/nonsolvent nature, its viscosity, pH, NAC addition to the nonsolvent, the polymer concentration and molecular weight, and NAC concentration in the solvent.e results showed that an increase in the nonsolvent viscosity produces NAC concentration in the solvent, and the nonsolvent rises its entrapment in the nanoparticles. Nanoparticles with 235.5 ± 11.4 nm size with an entrapment efficiency of 0.4 ± 0.04% and a specific load of 3.14 ± 0.33% were obtained. e results suggest that besides efficiently entrapping hydrophobic compounds, the nanoprecipitation method also has a high potential as an alternative entrapment method for hydrophilic compounds as well. However, its use in the pharmaceutical industry, as a proper specific load vehicle, still depends on the improvement of the load capacity.

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PLGA-based nanoparticles: A new paradigm in biomedical applications

Cited by 234 publications

References 63 publications

Novel biomaterial strategies for controlled growth factor delivery for biomedical applications

Novel biomaterial strategies for controlled growth factor delivery for biomedical applications

Nanodiamond in composite: Biomedical application

Improvement of N-Acetylcysteine Loaded in PLGA Nanoparticles by Nanoprecipitation Method

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