Pleuropulmonary blastoma, a distinctive neoplasm of childhood: report of three cases

Orazi, Cinzia; Inserra, Alessandro; Schingo, Paolo; Sio, Luigi De; Cutrera, Renato; Boldrini, Renata; Malena, S.

doi:10.1007/s00247-006-0402-0

Cited by 33 publications

(24 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rhabdomyosarcoma, pleuropulmonary blastoma and bronchioalveolar carcinoma are major malignancies known to be associated with CCAM [5,6,13]. The youngest age when these malignancies has been reported is 13 months for rhabdomyosarcoma [6], 9 months for pleuropulmonary blastoma [14,15], and 6 months for bronchioalveolar carcinoma [5].…”

Section: Discussionmentioning

confidence: 99%

Managing prenatally diagnosed asymptomatic congenital cystic adenomatoid malformation

et al. 2008

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Managing prenatally diagnosed asymptomatic congenital cystic adenomatoid malformation

et al. 2008

View full text Add to dashboard Cite

show abstract

“…These cell clusters resemble the mucogenic cells of gastrointestinal epithelium and have been implicated in the occurrence of bronchioloalveolar carcinoma described both in older patients with CCAM1 and in others who have had a CCAM1 removed in infancy [18][19][20][21] . Rhabdomyosarcoma and pleuropulmonary blastoma are yet other major malignancies known to be associated with CCAM [22][23][24] . The higher levels of cyclin D1 observed in cancer tissues may be due to its increased expression or to deregulated degradation [25] .…”

Section: Discussionmentioning

confidence: 99%

Overexpression of HOXB5, Cyclin D1 and PCNA in Congenital Cystic Adenomatoid Malformation

Wang

Wolgemuth²,

Baxi³

2011

Fetal Diagn Ther

View full text Add to dashboard Cite

Objective: We investigated the patterns of expression of HOXB5, cyclin D1 and proliferating cell nuclear antigen (PCNA) proteins in human congenital cystic adenomatoid malformation (CCAM) to establish the molecular basis of its etiology. Methods: Immunohistochemistry was performed on frozen archival specimens of CCAM and normal lung tissue as controls using antibodies against HOXB5, cyclin D1 and PCNA proteins. Results: Immunohistochemistry revealed a higher level of expression of HOXB5, cyclin D1 and PCNA predominantly in mesenchymal cells of the CCAM tissues as compared to normal adjacent control lung tissues. Conclusion: Elevated levels of immunohistochemical detection of HOXB5, cyclin D1 and PCNA were characteristic properties of lung tissue cells in CCAM. This elevated HOXB5 expression may correlate with the aberrant cellular differentiation observed in the CCAM disorder. Elevated expression of cyclin D1 and PCNA further suggests that increased cellular proliferation contributes to the overgrowth of lung tissue in CCAM.

show abstract

“…3,4 Previous studies have shown that histopathological type, mediastinal or pleural involvement, and metastases were correlated to the outcomes. 4,7 In summary, PPB is an extremely rare disease and most present symptom mimic respiratory infection. PPB should be considered in the differential diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Pleuropulmonary blastoma in an infant

et al. 2009

View full text Add to dashboard Cite

Pleuropulmonary blastomas (PPB) are rare and highly aggressive tumors. Herein, we report an infantile case of type III PPB. A 9-mth-old boy presented to our unit with a history of cough and tachypnea for 2 days. Chest computed tomography revealed a mass in the left upper lobe, emphysema in the left upper lung, and mediastinum and heart shifted towards the right. The mass was removed completely by left upper lobectomy and histology confirmed diagnosis of type III PPB. The immature blastematous tissue was positive for vimentin while benign epithelium was positive for epithelial membrane antigen and cytokeratin. No lymph nodule metastasis was found in the 7 lymph nodules obtained from the hilum of the lung near the tumor. Currently, the patient is under close follow-up and is doing well.

show abstract

Pleuropulmonary blastoma, a distinctive neoplasm of childhood: report of three cases

Cited by 33 publications

References 30 publications

Managing prenatally diagnosed asymptomatic congenital cystic adenomatoid malformation

Managing prenatally diagnosed asymptomatic congenital cystic adenomatoid malformation

Overexpression of HOXB5, Cyclin D1 and PCNA in Congenital Cystic Adenomatoid Malformation

Pleuropulmonary blastoma in an infant

Contact Info

Product

Resources

About