Pleural mesothelioma classification update

Beasley, Mary Beth; Galateau-Sallé, Françoise; Đačić, Sanja

doi:10.1007/s00428-021-03031-7

Cited by 58 publications

(79 citation statements)

References 73 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, clinical and morphological distinction between some entities (e.g., well-differentiated peritoneal mesothelioma or florid peritoneal mesothelial proliferations) may be difficult due to some overlapping morphological and immunohistochemical (IHC) features, including papillary structures, clinical symptoms and imaging findings [ 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 ]. This is mainly true if we also consider the new knowledge on the emerging entity of the mesothelioma in situ that can remain hidden for a long time [ 114 , 115 ].…”

Section: Discussionmentioning

confidence: 99%

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Vimercati

Cavone

Delfino

et al. 2021

Cancers

View full text Add to dashboard Cite

Primary ovarian mesothelioma is a rare, aggressive neoplastic disease with a poor prognosis. At onset, the tumor is only rarely limited to the ovaries and usually already widespread in the peritoneum. The rarity of this entity and the difficulties differentiating it from either ovarian carcinoma or peritoneal mesothelioma may lead to frequent misdiagnoses and may raise some concerns about its histogenesis. Thus, reporting such rare cases is fundamental to gain greater awareness of this neoplasm and try to answer unsolved questions. Herein, we described four cases of histological diagnoses of ovarian mesothelioma extrapolated by the regional mesothelioma register of Apulia (southern Italy). In all cases, a detailed medical history was collected according to national mesothelioma register guidelines. A broad panel of antibodies was used for immunohistochemistry to confirm the diagnoses. Moreover, ovarian tissue samples were also examined by transmission and scanning electron microscopy, detecting asbestos fibers and talc crystals in two cases. Because of the few cases described, we reviewed the English literature in the Medline database, focusing on articles about ovarian mesothelioma “misclassification”, “misdiagnosis”, “diagnostic challenge” or “diagnostic pitfall” and on unsolved questions about its histogenesis and possible risk factors.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Vimercati

Cavone

Delfino

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

“…Thoracentesis and analysis of body fluid cytology is frequently done for pleural effusions of unknown origin. In MPM, diagnosis can be challenging as cytologic features tend to be bland and the tissue invasion that is usually the reliable morphologic criteria for MPM cannot be assessed in a cytology preparation (10). Cytologic diagnosis is also limited to epithelioid subtypes as sarcomatoid subtypes do not shed fluid into the pleural effusions.…”

Section: Pathologic Stagingmentioning

confidence: 99%

Narrative review of staging and diagnosis of malignant pleural mesothelioma

Jordan¹,

Nitsche²,

Yendamuri³

2022

AME Surg J

View full text Add to dashboard Cite

Objective: Despite the aggressive nature of malignant pleural mesothelioma (MPM) its diagnosis and accurate staging remains elusive.Background: MPM is highly associated with asbestos exposure, but the long latency period makes exposure tracking a challenge. The disease often presents surreptitiously leading to late diagnosis and therefore poor prognosis. Patients often present with symptoms such as dyspnea, chest pain, fatigue, and cough that are suggestive of many thoracic ailments such as lung cancer, pneumothorax, and pneumonia.Consequently, these patients often receive a CT scan as the first step towards diagnosis. If the results of the CT scan are suggestive of mesothelioma, such as if diffuse pleural thickening or a rind is seen, a biopsy is the next intervention sought. A thoracoscopic biopsy is often preferred over a core needle biopsy and is paramount for diagnosis and subsequent treatment plan optimization. PET scans have been useful in determining the spread of the disease while MRI has been a tool in determining respectability. In an effort to optimize care for these patients, staging guidelines have evolved and now align with those utilized with solid tumors such as sarcoma. The current classification system is the eighth edition of the TNM system published by the International Mesothelioma Interest Group (IMIG) for MPM. This edition incorporates changes in the T and N classifications and differs from previous guidelines that focused on surgical management of the disease. In an effort to improve clinical decision making and prognostication novel staging approaches, including volumetric staging, have been proposed. Diagnosis and treatment of MPM is further complicated by the difference in behavior and tumor marker expression of the epithelioid subtype and the sarcomatoid subtypes Methods: Utilizing computerized databases, literature pertaining to the diagnosis and staging of MPM was analyzed. We focused on the utility of current imaging strategies, staging systems, and pathologic analysis.Conclusions: MPM remains a challenge to diagnose and treat. The increased integration of advanced imaging modalities will likely aid in diagnosis of MPM. Advancements in diagnosis will predictably go handin-hand with more precise staging systems that will overall improve prognostication and survival.

show abstract

“…The epithelioid form is more common and related to a better prognosis than the non-epithelial one. Phenotypically, MPM cells are a polygonal or cobblestone-like shape in the epithelioid histotype, while a spindle-like form has been associated with the sarcomatoid MPM type [11]. MPM diagnosis is based on imaging modalities and the evaluation of diagnostic and prognostic biomarkers, such as mesothelin, BRCA-1 associated protein (BAP1), osteo-pontin, fibulin 3 and cytokeratins.…”

Section: Malignant Pleural Mesotheliomamentioning

confidence: 99%

The Epithelial-to-Mesenchymal Transition (EMT) in the Development and Metastasis of Malignant Pleural Mesothelioma

Ramundo

Zanirato

Aldieri

2021

IJMS

View full text Add to dashboard Cite

Malignant pleural mesothelioma (MPM) is an aggressive tumor mainly associated with asbestos exposure and is characterized by a very difficult pharmacological approach. One of the molecular mechanisms associated with cancer onset and invasiveness is the epithelial-to-mesenchymal transition (EMT), an event induced by different types of inducers, such as transforming growth factor β (TGFβ), the main inducer of EMT, and oxidative stress. MPM development and metastasis have been correlated to EMT; On one hand, EMT mediates the effects exerted by asbestos fibers in the mesothelium, particularly via increased oxidative stress and TGFβ levels evoked by asbestos exposure, thus promoting a malignant phenotype, and on the other hand, MPM acquires invasiveness via the EMT event, as shown by an upregulation of mesenchymal markers or, although indirectly, some miRNAs or non-coding RNAs, all demonstrated to be involved in cancer onset and metastasis. This review aims to better describe how EMT is involved in driving the development and invasiveness of MPM, in an attempt to open new scenarios that are useful in the identification of predictive markers and to improve the pharmacological approach against this aggressive cancer.

show abstract

Pleural mesothelioma classification update

Cited by 58 publications

References 73 publications

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Primary Ovarian Mesothelioma: A Case Series with Electron Microscopy Examination and Review of the Literature

Narrative review of staging and diagnosis of malignant pleural mesothelioma

The Epithelial-to-Mesenchymal Transition (EMT) in the Development and Metastasis of Malignant Pleural Mesothelioma

Contact Info

Product

Resources

About