Pleural mesothelioma and exposure to asbestos: evaluation from work histories and analysis of asbestos bodies in bronchoalveolar lavage fluid or lung tissue in 131 patients.

Pairon, Jean‐Claude; Orlowski, Ewa; Iwatsubo, Y.; Billon-Galland, Marie-Annick; Dufour, G; Chamming’s, Soizick; Archambault, Cyril; Bignon, J.; Brochard, Patrick

doi:10.1136/oem.51.4.244

Cited by 29 publications

(10 citation statements)

References 22 publications

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“…Median values were 121 AB·mL -1 in asbestosis, 5 AB·mL -1 in benign pleural disease and 4 AB·mL -1 in exposed workers without evidence of an asbestos-related disease. Similar results have been published in smaller series of patients [39,43,44].…”

Section: Bronchoalveolar Lavagesupporting

confidence: 79%

Guidelines for mineral fibre analyses in biological samples: report of the ERS Working Group. European Respiratory Society

Vuyst¹,

Karjalainen²,

Dumortier³

et al. 1998

Eur Respir J

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152

107

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aaAsbestos comprises a group of six hydrated silicate minerals capable of forming very thin fibres: chrysotile, crocidolite, amosite, anthophyllite, tremolite and actinolite [1]. Chrysotile belongs to the serpentine group and the other five to the amphibole group of minerals. Chrysotile fibre bundles split easily and magnesium can be leached under weak acid conditions. These factors may contribute to the lower biopersistence of chrysotile in the lungs.

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Section: Bronchoalveolar Lavagesupporting

confidence: 79%

Guidelines for mineral fibre analyses in biological samples: report of the ERS Working Group. European Respiratory Society

Vuyst¹,

Karjalainen²,

Dumortier³

et al. 1998

Eur Respir J

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152

107

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“…Most studies concerned with asbestos fibres or bodies in the human lungs have compared their concentrations with exposure characteristics and/or associated diseases in specific groups [10][11][12][13][14][15]. The changes in the use of asbestos have only been taken into account exceptionally in the interpretation of mineralogical findings [16].…”

Section: Discussionmentioning

confidence: 99%

Trends in asbestos body counts in bronchoalveolar lavage fluid over two decades

Dumortier¹,

Thimpont²,

Maertelaer³

et al. 2003

Eur Respir J

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Trends in asbestos body counts in bronchoalveolar lavage fluid over two decades. P. Dumortier, J. Thimpont, V. de Maertelaer, P. De Vuyst. #ERS Journals Ltd 2003. ABSTRACT: As in most western countries, the use of asbestos has decreased in Belgium since the mid 19709s. Successive regulations have lowered the permissible levels of exposure and prohibited the use of various asbestos products.In order to assess the impact of these prevention measures on the pulmonary fibre burden of asbestos-exposed patients, the bronchoalveolar lavage fluid (BALF) asbestos body (AB) analysis database of the authors9 laboratory was reviewed for the period 1983-2000.A total of 4,772 cases were considered, of which 95% were males. AB concentration exceeded 1 AB?mL BALF -1 in 36.1%. There was essentially no change in the mean concentration of AB over the period evaluated. However, the concentrations in individuals with very high levels decreased over time. This was associated with a shift in exposure categories from primary asbestos workers to those exposed during handling of asbestos-containing materials or to asbestos in place in buildings or industrial sites. This is consistent with epidemiological data indicating that the number of severe cases of asbestosis caused by very high cumulated doses decreases but that benign pleural diseases and mesothelioma remain the most frequent asbestos-related diseases. Past prevention measures are not expected to have a measurable influence on the incidence of mesothelioma in the near future.

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“…It has been well documented that malignant mesothelioma is a neoplasm associated with asbestos exposure [Carbone et al, 2002]; however, no definite evidence of exposure to asbestos could be found in the work histories of some patients [Pairon et al, 1994;Hirvonen et al, 1999]. These investigations suggest that there are other factors involved in the pathogenesis of malignant mesothelioma.…”

Section: Introductionmentioning

confidence: 92%

Investigation of simian virus 40 large T antigen in 18 autopsied malignant mesothelioma patients in Japan

Jin

Sawa²,

Suzuki³

et al. 2004

Journal of Medical Virology

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It has been reported that Simian virus 40 (SV40) is linked to human beings by inoculation of contaminated poliovaccines and may have a role in the etiology of malignant mesothelioma. However, there have been no reports describing the relationship between SV40 and malignant mesothelioma in Japan. A study was undertaken to investigate whether SV40 was related to patients of malignant mesothelioma in Japan by the polymerase chain reaction (PCR) assay, DNA sequence analysis, and immunohistochemical methods. Paraffin-embedded samples of the 18 autopsied patients with pleural malignant mesothelioma were collected from five hospitals in Japan. After isolation of DNA from paraffin blocks, PCR analyses followed by sequencing were performed using three different sets of primers for detection of SV40 large T antigen (TAg) gene. All 18 malignant mesothelioma samples were also immunohistochemically evaluated for expression of SV40 TAg protein with two different anti-SV40 TAg antibodies. SV40 TAg genome was detected in eight malignant mesothelioma cases. Only one of three primer pairs successfully amplified SV40 genome in the samples, whereas all pairs yielded a PCR product in the controls, suggesting a low content of virus DNA. No immunopositive staining for SV40 TAg was found in any of the samples. This study shows that SV40 genome was present in a subset of Japanese malignant mesothelioma patients who were unlikely to have received a contaminated polio vaccine based on their age.

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Pleural mesothelioma and exposure to asbestos: evaluation from work histories and analysis of asbestos bodies in bronchoalveolar lavage fluid or lung tissue in 131 patients.

Abstract: Exposure to asbestos was evaluated in 131 patients with pleural malignant

Cited by 29 publications

References 22 publications

Guidelines for mineral fibre analyses in biological samples: report of the ERS Working Group. European Respiratory Society

Guidelines for mineral fibre analyses in biological samples: report of the ERS Working Group. European Respiratory Society

Trends in asbestos body counts in bronchoalveolar lavage fluid over two decades

Investigation of simian virus 40 large T antigen in 18 autopsied malignant mesothelioma patients in Japan

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