Pleural lavage cytology: Where do we stand?

Toufektzian, Levon; Sepsas, Evangelos; Drossos, Vasileios; Gkiozos, Ioannis; Syrigos, Konstantinos

doi:10.1016/j.lungcan.2013.10.012

Cited by 17 publications

(16 citation statements)

References 35 publications

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“…This may simply reflect the judgment and common practice of physicians faced with a symptomatic large effusion. It should be stressed that the incidence of malignant pleural involvement in lung cancer may be underestimated for at least three reasons: (i) minimal effusions may in fact represent an undemonstrated malignancy, (ii) there may be dry pleural dissemination without pleural fluid accumulation, and (iii) a microscopic pleural disease could be discovered through a pleural lavage cytology during surgery . We found that patients with pleural nodules and/or thickening of a probable or definite malignant nature were more prone to develop effusions and survived 2.5 months less than those without pleural lesions.…”

Section: Discussionmentioning

confidence: 74%

Clinical features and survival of lung cancer patients with pleural effusions

et al. 2015

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Section: Discussionmentioning

confidence: 74%

Clinical features and survival of lung cancer patients with pleural effusions

et al. 2015

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“…However, in this case, tumoral occlusion in the left main bronchus prevented cytological positivity with either a sputum or pleural effusion specimen. The cytological positivity of pleural effusion in lung cancer in the literature is 3.7–38.6% [13]. …”

Section: Discussionmentioning

confidence: 99%

Endocardial Invasion of Lung Cancer Undiagnosable before Autopsy

Mizuno¹,

Ishigami²,

Yamada

et al. 2014

Case Rep Oncol

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A 59-year-old male patient presented with left chest discomfort on admission. His medical history included encephalitis in childhood and his smoking history was 20 cigarettes per day for 40 years. A physical examination showed an anemic and edematous face with weak respiratory sounds in the left lung. The patient had elevated calcium levels and decreased hemoglobin and potassium. His parathyroid hormone-related protein level was elevated. Thoracic radiography showed cardiomegaly and computed tomography revealed a left lung mass with invasion of the heart and pleural effusion. Magnetic resonance imaging showed endocardial invasion of the tumor mass. Gallium-68 imaging revealed positive accumulation in the region surrounding the heart. No diagnoses were possible upon frequent cytology of his sputum and pleural effusion. The patient died from congestive heart failure with anoxia 38 days after admission. An autopsy revealed tumoral mass occlusion in the left main bronchus and tumoral invasion of the left atrium, left ventricle, and aorta.

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“…[16] Pleural lavage performed during lung resection may show malignant cells in the absence of an effusion, predicting a higher risk of cancer recurrence and poorer outcome (median survival 12 months vs. 49 months for those with a negative lavage). [17] Recent data suggest that lung cancer cells in the pleural fluid may have discordant mutation statuses from the primary tumor, [18] a finding that may influence management.…”

Section: Diagnosis Of Hepatic Hydrothoraxmentioning

confidence: 99%

The diagnosis of pleural effusions

Porcel

Azzopardi

Koegelenberg

et al. 2015

Expert Review of Respiratory Medicine

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Pleural effusions arise from a variety of systemic, inflammatory, infectious and malignant conditions. Their precise etiological diagnosis depends on a combination of medical history, physical examination, imaging tests and pertinent pleural fluid analyses; including specific biomarkers (e.g., natriuretic peptides for heart failure, adenosine deaminase for tuberculosis, or mesothelin for mesothelioma). Invasive procedures, such as pleuroscopic biopsies, may be required for persistently symptomatic effusions which remain undiagnosed after the analysis of one or more pleural fluid samples. However, whenever parietal pleural nodularity or thickening exist, image-guided biopsies should first be attempted. This review addresses the current diagnostic approach to pleural effusions secondary to heart failure, pneumonia, cancer, tuberculosis and other less frequent conditions.

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Pleural lavage cytology: Where do we stand?

Cited by 17 publications

References 35 publications

Clinical features and survival of lung cancer patients with pleural effusions

Clinical features and survival of lung cancer patients with pleural effusions

Endocardial Invasion of Lung Cancer Undiagnosable before Autopsy

The diagnosis of pleural effusions

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