Plesiomonas shigelloides in acute cholecystitis: a case report

Claesson, Berndt E. B.; Holmlund, D; Lindhagen, C A; Mätzsch, Thomas

doi:10.1128/jcm.20.5.985-987.1984

Cited by 36 publications

(7 citation statements)

References 11 publications

(7 reference statements)

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“…Accurate estimates of the incidence of Plesiomonas-related gastroenteritis and extraintestinal infections both globally and at the level of individual countries remain unknown [1,2,[4][5][6][7]10,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. Retrospective reviews of infections due to P. shigelloides in China and Hong Kong have been published [38], and cases of P. shigelloides co-infection with viral and bacterial diarrheal pathogens are common in the literature [39].…”

Section: Introductionmentioning

confidence: 99%

A global bibliometric analysis of Plesiomonas-related research (1990 – 2017)

2018

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Plesiomonas shigelloides is an emerging pathogen with damaging effects on human health such as gastroenteritis and extraintestinal infections. Here, we carried out a bibliometric survey that aimed to examine publication trends in Plesiomonas-related research by time and place, international collaborative works, identify gaps and suggest directions for future research. The search term “Plesiomonas shigelloides” was used to retrieve articles published between 1990 and 2017 from the Web of Science database. Only primary research articles were included in the analysis. A total of 155 articles were published within the survey period, with an average of 5.54±2.66 articles per year and an annual growth rate of −0.8%. Research output peaked in 2000 and 2006 (each accounting for 7.7% of the total). The United States ranked first in terms of numbers of articles (n = 29, 18.1%) and total citations (n = 451). Cameroon, Canada, Cuba, Switzerland and Turkey co-shared the 10th position each with 2 articles (1.3%). Research collaboration was low (collaboration index = 3. 32). In addition to Plesiomonas shigelloides (n = 82, 52.9%), the top Authors Keywords and research focus included lipopolysaccharide and nuclear magnetic resonance (n = 13, 8.4%). Diarrhea (n = 43, 27.7%), Aeromonas species (n = 41, 26.5%) and infections (n = 31, 20.0%) were also highly represented in Keywords-Plus. Authors’ collaborations and coupling networks formed two mega-clusters which nodes were shared solely by authors from high-income countries. The common conceptual framework in retrieved articles determined by K-means clustering revealed three clusters with sizes of 7, 16, and 29, representing research responses focused on extraintestinal and gastroenteritis, P. shigelloides lipopolysaccharide structure, and co-infections, respectively. Our bibliometric analysis revealed a global diminishing research in Plesiomonas; greater research outcomes from high-income countries compared to others and low collaboration with developing countries.

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Section: Introductionmentioning

confidence: 99%

A global bibliometric analysis of Plesiomonas-related research (1990 – 2017)

2018

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“…2000). This species has also been implicated in an increasing number of extraintestinal infections, such as septicaemia, meningitis, cholecystitis, osteomyelytis and pseudoappendicitis (Claesson et al. 1984; Fischer et al.…”

Section: Introductionmentioning

confidence: 99%

Intracellular vacuolation induced by culture filtrates of Plesiomonas shigelloides isolated from environmental sources

et al. 2003

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Aims: Potential virulence factors produced by culture filtrates of Plesiomonas shigelloides isolated from water were investigated. Methods and Results: Culture filtrates of P. shigelloides strains were assayed for cytotoxic activity in CHO (Chinese hamster ovary), Vero (African green monkey kidney), HeLa (human cervix), HT29 (human epithelial intestinal) and SK6 (swine epithelial kidney) cells. Microscopic analyses revealed intensive cytoplasmic vacuolation including cell rounding and swelling, with gradual destruction of the monolayer in filtrate-treated cells. Neutral red assays showed that CHO, HeLa and Vero cells were the most sensitive to the vacuolating activity, which was evident within 30 min of culture filtrate exposure. This activity was inactived by heating at 56°C for 15 min and partially neutralized by antiserum to the cytotoxin of Aeromonas hydrophila. All P. shigelloides strains had a cell-associated haemolysin in the agar plate assay. Three isolates were found to produce a cell-free haemolytic activity at 37°C. In the suckling mouse test, two P. shigelloides culture supernatants were positive for enterotoxic activity. Conclusions: P. shigelloides culture filtrates isolated from aquatic environment cause intracellular vacuolation on mammalian cells, and produce haemolytic and enterotoxic activities. Significance and Impact of the Study: This work revealed the presence of putative virulence factors that could be associated with human infections involving Plesiomonas strains.

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“…This was further supported by various extraintestinal infections associated with Plesiomonas , including peritonitis (Alcañiz et al, 1995; Patel et al, 2016), cellulitis (Gopal and Burns, 1991; Jönsson et al, 1998), wound and foot infections (McCracken and Barkley, 1972; Herve et al, 2007; Pence, 2016), endophthalmitis (Butt et al, 1997; Mahrshmann and Lyons, 1998), and keratitis (Butt et al, 1997; Klatte et al, 2012). In addition, pneumonia (Schneider et al, 2009), migratory polyarthritis (Gupta, 1995), cholecystitis (Claesson et al, 1984; Kennedy et al, 1990), pyosalpinx (Roth et al, 2002), pseudo-appendicitis (Fischer et al, 1988), cholangitis and pancreatitis (Kennedy et al, 1990) are examples of infections that required invasive factor that have been reported caused by Plesiomonas . Further, Binns et al (1984) showed that 31.3% of examined strains are invasive toward HeLa cells.…”

Section: Discussionmentioning

confidence: 99%

“…These include gastroenteritis and various forms of diarrhea (Tsukamoto et al, 1978; Wong et al, 2000; Chakour et al, 2002; Klontz et al, 2012; Pfeiffer et al, 2012; Novoa-Farías et al, 2016). Of major concern are extraintestinal infections of the central nervous system, such as neonatal meningoencephalitis, meningitis, sepsis, and septic shock (Claesson et al, 1984; Kalotychou et al, 2002; Auxiliadora-Martins et al, 2010; Ozdemir et al, 2010; Xia et al, 2015; Bowman et al, 2016). Other infections include peritonitis (Alcañiz et al, 1995), cellulitis (Gopal and Burns, 1991; Jönsson et al, 1998), wound and foot infections (McCracken and Barkley, 1972; Herve et al, 2007; Pence, 2016), endophthalmitis (Butt et al, 1997; Mahrshmann and Lyons, 1998), and keratitis (Butt et al, 1997; Klatte et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Pathogenomics of Virulence Traits of Plesiomonas shigelloides That Were Deemed Inconclusive by Traditional Experimental Approaches

Ekundayo

Okoh

2018

Front. Microbiol.

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One of the major challenges of modern medicine includes the failure of conventional protocols to characterize the pathogenicity of emerging pathogens. This is particularly apparent in the case of Plesiomonas shigelloides. Although a number of infections have been linked to this microorganism, experimental evidence of its virulence factors (VFs), obtained by traditional approaches, is somewhat inconclusive. Hence, it remains unclear whether P. shigelloides is a true or opportunistic one. In the current study, four publicly available whole-genome sequences of P. shigelloides (GN7, NCTC10360, 302-73, and LS1) were profiled using bioinformatics platforms to determine the putative candidate VFs to characterize the bacterial pathogenicity. Overall, 134 unique open reading frames (ORFs) were identified that were homologous or orthologous to virulence genes identified in other pathogens. Of these, 52.24% (70/134) were jointly shared by the strains. The numbers of strain-specific virulence traits were 4 in LS1; 7 in NCTC10360; 10 in 302-73; and 15 in GN7. The pathogenicity islands (PAIs) common to all the strains accounted for 24.07% ORFs. The numbers of PAIs exclusive to each strain were 8 in 302-73; 11 in NCTC10360; 14 in GN7; and 18 in LS1. A PAI encoding Vibrio cholerae ToxR-activated gene d protein was specific to 302-73, GN7, and NCTC10360 strains. Out of 33 antibiotic multi-resistance genes identified, 16 (48.48%) genes were intrinsic to all strains. Further, 17 (22.08%) of 77 antibiotic resistance islands were found in all the strains. Out of 23 identified distinct insertion sequences, 13 were only harbored by strain LS1. The number of intact prophages identified in the strains was 1 in GN7; 2 in 302-73; and 2 in NCTC10360. Further, 1 CRISPR element was identified in LS1; 2 in NCTC10360; and 8 in 302-73. Fifteen (78.95%) of 19 secretion systems and secretion effector variants were identified in all the strains. In conclusion, certain P. shigelloides strains might possess VFs associated with gastroenteritis and extraintestinal infections. However, the role of host factors in the onset of infections should not be undermined.

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Plesiomonas shigelloides in acute cholecystitis: a case report

Cited by 36 publications

References 11 publications

A global bibliometric analysis of Plesiomonas-related research (1990 – 2017)

A global bibliometric analysis of Plesiomonas-related research (1990 – 2017)

Intracellular vacuolation induced by culture filtrates of Plesiomonas shigelloides isolated from environmental sources

Pathogenomics of Virulence Traits of Plesiomonas shigelloides That Were Deemed Inconclusive by Traditional Experimental Approaches

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