Pleomorphic xanthoastrocytoma with malignant transformation and multiple recurrences in an Iranian girl

Binesh, Fariba; Akhavan, Ali; Navabii, Hossein

doi:10.1136/bcr.12.2011.5372

Cited by 12 publications

(15 citation statements)

References 29 publications

(36 reference statements)

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“…Study designs were primarily single case reports (n = 16 articles [2–4, 9, 16–17, 19–22, 24, 29, 31–32, 36–37], 19 patients) and cross-sectional studies (n = 15 articles [7–8, 10–14, 15, 18, 25–26, 28, 30, 33–34], 3,271 patients). Other study designs included cohort (n = 2 articles [23, 35], 131 patients), case series (n = 1 article [5], 7 patients), and case control (n = 1 article [27], 56 patients) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Of the 18 articles categorized as clinical, 13 were case reports (19 patients) [2–4, 9, 17, 19–20, 22, 24, 31–32, 36–37]; two were cross-sectional studies (98 patients); two were cohort studies (98 patients); and one was a case-control study (56 patients). Clinical case reports described the disease presentation and management for each patient.…”

Section: Resultsmentioning

confidence: 99%

“…Clinical case reports described the disease presentation and management for each patient. Of the 35 total pediatric study articles, six (published from 2006 to 2014) described the prediagnostic symptomatic interval (PSI) in children with CNS tumors [2, 5, 12, 19, 24, 33]. The follow-up of patients, 5-year overall survival, and event-free survival rates were reported in nine articles [8, 23, 25–28, 30, 33, 35].…”

Section: Resultsmentioning

confidence: 99%

“…A large majority (77%) of the pediatric studies were conducted in Tehran province. The remaining eight studies were conducted in eight other provinces [2, 3, 7, 9, 10, 14, 24, 30]. Because the city of Tehran contains three major pediatric cancer referral centers and pediatric patients in Iran are frequently referred to these centers, it is not surprising that most of the studies were conducted there.…”

Section: Discussionmentioning

confidence: 99%

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Comprehensive analysis of Iranian reports of pediatric central nervous system tumors

Mehrvar

Akbari

et al. 2017

Childs Nerv Syst

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Purpose Iran lacks a national registry reporting the data of central nervous system (CNS) tumors in children. Consequently, treatment success and failure rates are unknown, and a centralized system for disease-management recommendations does not exist. Methods To critically evaluate the current state of pediatric CNS tumor studies and reporting in Iran, we performed an extensive retrospective analysis of all known reports identified with multiple search engines. Results Of 409 initially retrieved articles, we evaluated 123 matching our inclusion criteria. We further narrowed these reports to 74 by excluding studies pertaining to adult patients only, non-CNS tumors, or brain metastases. We also excluded studies that were performed outside of Iran or that did not contain relevant data from our analysis. We divided the remaining studies into those describing exclusively pediatric patients (3,484 patients) and those describing mixed populations of adults and children (18,641 patients). In total, our analysis included 22,125 patients. Conclusions We identified many limitations in the reporting of studies describing the treatment or prevalence of CNS tumors in children in Iran. Our results may guide future efforts in Iran to improve the care for children with CNS tumors and may provide a valuable template for other comprehensive country- and disease-specific retrospective analyses.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Comprehensive analysis of Iranian reports of pediatric central nervous system tumors

Mehrvar

Akbari

et al. 2017

Childs Nerv Syst

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“…Histologically, APXA is defined when, in addition to PXA, mitoses number 5 or more per high-power field while GBM displays nuclear atypia, cellular pleomorphism, mitotic activity, a diffuse growth pattern, microvascular proliferation and/or necrosis [1]. Thus, these tumors have similar histological findings which may cause clinical confusion [4,5]. BRAFV600 E mutations are seen in 7.7~9.1% of GBM, 63~75% of PXA and 47.4~57% of APXA cases [1,3,6,7].…”

Section: Introductionmentioning

confidence: 99%

Malignant transformation of pleomorphic xanthoastrocytoma and differential diagnosis: case report

et al. 2020

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Background: Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytic glioma, characterized by large pleomorphic and frequently multinucleated cells, spindle and lipidized cells, a dense pericellular reticulin network, and numerous eosinophilic granular bodies according to the grade II glial tumor standards of the World Health Organization's (WHO) 2016 guidelines. PXA rarely transforms into anaplastic PXA or glioblastoma (GBM) and anaplastic PXA, classified as WHO grade III, has a more aggressive clinical behavior with poorer prognosis than PXA. Case presentation: Here we describe an unusual case of PXA in a 19-year-old woman, first admitted with headache and a mass in the left temporal lobe in 2005 that was removed. Twelve years later, she returned with left temporal headache, diplopia and tinnitus. A local tumor recurrence was found, and a second resection was performed. The specimen showed highly malignant findings, such as necrosis, microvascular proliferation, and multiple mitoses. The integrated diagnosis was made as high grade glioma, probably derived from PXA. Immunohistochemical (IHC) stains were positive for oligo2, and approximately 21% positive for Ki-67, while negative for CD34, IDH1 R132H. INI1 and ATRX were retained. As the histological classification was glioblastoma, the patient received GBM-appropriate chemotherapy and radiation therapy and outpatient follow-ups have demonstrated no obvious symptoms for 1 year after surgery. Additional molecular analyses found BRAF V600E mutations in both resections, supporting the idea that the recurrent tumor had derived from PXA. Conclusions: This case highlights the complexities of differential diagnosis based on the World Health Organization's 2016 guidelines. More integrated criteria to differentiate anaplastic PXA from GBM and epithelioid GBM, combined with genetic screening results, might be needed.

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A rare clinical presentation: a pleomorphic xanthoastrocytoma presenting with intracerebral haemorrhage and metastasizing vigorously—case report and review of the literature

Otluoglu

Özek

2018

Childs Nerv Syst

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Metastasis of an intracranial tumour is not a common situation in our daily neurosurgical practice. Pleomorphic xanthoastrocytoma is also a rare glial tumour with relatively a favourable prognosis among other CNS pathologies. Here, we present an anaplastic pleomorphic xanthoastrocytoma case which shows both haematogenous and lymphatic metastasis which is described first time in the up-to-date literature. Our case is a 17-year-old male operated for a right occipital intra-axial lesion with a diagnosis of anaplastic pleomorphic xanthoastrocytoma which recurs 5 years later and metastasize vigorously through haematogenous and lymphatic routes. A rare-presenting symptom for this pathology is also intracerebral haemorrhage. This is the ninth case report in the literature which presents initially with this entity.

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Pleomorphic xanthoastrocytoma with malignant transformation and multiple recurrences in an Iranian girl

Cited by 12 publications

References 29 publications

Comprehensive analysis of Iranian reports of pediatric central nervous system tumors

Comprehensive analysis of Iranian reports of pediatric central nervous system tumors

Malignant transformation of pleomorphic xanthoastrocytoma and differential diagnosis: case report

A rare clinical presentation: a pleomorphic xanthoastrocytoma presenting with intracerebral haemorrhage and metastasizing vigorously—case report and review of the literature

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