Pleomorphic liposarcoma of a young woman following radiotherapy for epithelioid sarcoma

Orosz, Zsolt; Rohonyi, Béla; Luksander, Antal; Szántó, J.

doi:10.1007/bf03187333

Cited by 11 publications

(11 citation statements)

References 14 publications

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“…It is reported that 11% of irradiated giant cell tumours can transform to sarcoma in contrast to less than 1% of giant cell tumours in general [1,25]. The number of radiation-induced liposarcomas is low, and only one case was observed in our material [26]. This is in contrast to spontaneous sarcomas where liposarcomas belong to the most common histological subtypes [1].…”

Section: Discussionmentioning

confidence: 57%

Radiation-induced sarcoma: 25-year experience from The Norwegian Radium Hospital

et al. 2008

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Section: Discussionmentioning

confidence: 57%

Radiation-induced sarcoma: 25-year experience from The Norwegian Radium Hospital

et al. 2008

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“…The fact that the tumor must arise in the region of a prior irradiation, having a latency period of at least two years, and proof that the sarcoma is histologically different from the radiated primary lesion are the criteria of postradiation sarcoma modified by Laskin et al [ 4 , 8 ]. A high rate of TP53 gene mutation was observed in radiation-induced sarcomas compared to sporadic ones with studies examining mutations in specific genes using polymerase chain reaction followed by direct sequencing (88% versus 20% and 58% versus 16.8% for two different series) [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Generally accepted criteria to diagnose a postirradiation sarcoma (PIS) include treatment with therapeutic irradiation at least two years prior to development of a sarcoma, a sarcoma arising within the field of previous therapeutic irradiation, and different histologic features between the sarcoma and the primary tumor that required radiotherapy [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Fourth Primary Malignant Tumor in a Patient with Possible Li-Fraumeni Syndrome: Synchronous Diagnosis of Postirradiation Sarcoma, Cutaneous Relapse of a Previous Soft Tissue Sarcoma, and Lung Adenocarcinoma

Yumrukçal

Dirik

Çınar

et al. 2014

Case Reports in Orthopedics

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We present a 46-year-old female patient who is diagnosed with synchronous postirradiation sarcoma, cutaneous relapse of a previous soft tissue sarcoma, and lung adenocarcinoma. More than one malignant tumor at the same time with an accompanying relapse of a previous malignant tumor is a rare entity. A relatively young patient diagnosed with adenocarcinoma of the urethra before age 40, which is an unusual tumor for that age, later three more different malignant tumors being diagnosed, two of which are synchronous, causes the suspicion of Li-Fraumeni syndrome.

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“…Radiation-induced liposarcoma has been reported infrequently, but Orosz et al [8] described the case of radiation-induced liposarcoma which showed dedifferentiation toward pleomorphic malignant fibrous histiocytoma. Atomic bomb survivors are known to have a high risk of developing various malignant and benign tumors [1].…”

Section: Discussionmentioning

confidence: 99%

Dedifferentiated Liposarcoma in the Retroperitoneum in an Atomic Bomb Survivor: Report of a Case

Nakamura¹,

Yumiba²,

Yamasaki³

et al. 2008

Case Rep Gastroenterol

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A 76-year-old Japanese man was admitted to Kosei-Nenkin Hospital (Osaka, Japan) in November 2006; his chief complaint was a 10-kg loss in body weight over 3 months prior to admission. Abdominal computed tomography (CT) and dynamic magnetic resonance imaging (MRI) showed three masses in the retroperitoneum. The patient subsequently underwent surgery. The final histopathological diagnosis of tumors 1 and 2 was malignant fibrous histiocytoma of the retroperitoneum, and tumor 3 was a well-differentiated liposarcoma. By the presence of the liposarcoma, tumor 1 and 2 were thought to be the dedifferentiated areas of liposarcomas. At the age of 16, the patient had been exposed to radiation from the atomic bomb at Hiroshima towards the end of the Second World War. We postulate that in this case, radiation from the atomic bomb may have played an important role in the development of the sarcomas.

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Pleomorphic liposarcoma of a young woman following radiotherapy for epithelioid sarcoma

Cited by 11 publications

References 14 publications

Radiation-induced sarcoma: 25-year experience from The Norwegian Radium Hospital

Radiation-induced sarcoma: 25-year experience from The Norwegian Radium Hospital

Fourth Primary Malignant Tumor in a Patient with Possible Li-Fraumeni Syndrome: Synchronous Diagnosis of Postirradiation Sarcoma, Cutaneous Relapse of a Previous Soft Tissue Sarcoma, and Lung Adenocarcinoma

Dedifferentiated Liposarcoma in the Retroperitoneum in an Atomic Bomb Survivor: Report of a Case

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