Radiation-induced sarcoma: 25-year experience from The Norwegian Radium Hospital

Bjerkehagen, Bodil; Smeland, Sigbjørn; Walberg, Lise; Skjeldal, Sigmund; Hall, Kirsten Sundby; Nesland, Jahn M.; Småstuen, Milada Cvancarova; Fosså, Sophie D.; Sæter, Gunnar

doi:10.1080/02841860802047387

Cited by 98 publications

(80 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…14 Another study showed 63 per cent survival at five years for patients who had undergone complete excision; in contrast, the survival rate was only 10 per cent for patients in whom at least one surgical margin was not cleared of tumour. 15 Adjuvant therapy is limited in the treatment of radiationinduced sarcoma. As these tumours are radiation induced, they are generally considered to be radiation resistant, and adjuvant radiation therapy is limited by previous radiation.…”

Section: Discussionmentioning

confidence: 99%

Radiation-induced sarcoma masquerading as osteoradionecrosis: case report and literature review

et al. 2015

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Radiation-induced sarcoma masquerading as osteoradionecrosis: case report and literature review

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Nevertheless, considering the possible scope of the radiation field and the passage of an adequate latency period, one might conjecture that in this case SRMS developed as a radiation-induced sarcoma. The development of RMS as a sequela of radiation therapy is exceedingly rare, with pleomorphic undifferentiated sarcoma (malignant fibrous histiocytoma) and osteosarcoma representing the most common types of radiation-induced sarcoma [19,20]. The etiology of RMS is largely unknown, although in some cases genetic factors have been implicated by an association with various heritable conditions, such as Li Fraumeni syndrome, Beckwith-Wiedemann syndrome, and neurofibromatosis type 1 [18].…”

Section: Discussionmentioning

confidence: 99%

Sclerosing Rhabdomyosarcoma: Report of a Case Arising in the Head and Neck of an Adult and Review of the Literature

Robinson

Richardson

Neville

et al. 2012

Head and Neck Pathol

View full text Add to dashboard Cite

Sclerosing rhabdomyosarcoma is a unique rhabdomyosarcoma variant, characterized by a prominent hyalinizing matrix. A notable pitfall is the potential for the unusual matrix and often pseudovascular growth pattern of this lesion to lead to confusion with other sarcoma types, including osteosarcoma, chondrosarcoma, and angiosarcoma. Here we report a case of sclerosing rhabdomyosarcoma arising in a 40-year old male. The tumor was centered in the pterygomaxillary fossa with extensive infiltration into adjacent structures. Fine needle aspiration yielded a preliminary diagnosis of high-grade pleomorphic undifferentiated sarcoma, for which he received neoadjuvant chemotherapy and surgical resection. Microscopic examination showed a malignant spindled to round cell neoplasm with prominent osteoid-like, hyaline stroma. Focal rhabdomyoblastic differentiation and diffuse immunoreactivity for desmin and myogenin aided in diagnosis. Nineteen months status post primary resection, the patient expired with multiple lung and bony metastases. Among 39 cases reported thus far (including the present case), there is a broad age range (0.3-79 years), with an average age at presentation of 27 years. The most commonly involved sites are the extremities (n = 19) and head and neck (n = 15). Most cases have been treated by resection, often combined with radiation and/or chemotherapy. Out of 31 cases with follow-up information provided, 6 patients developed local recurrence, 7 patients developed regional or distant metastasis, and 5 patients died of disease. Herein we discuss the ongoing controversy regarding how sclerosing rhabdomyosarcoma might best fit into existing rhabdomyosarcoma classification schemes, based upon current clinicopathologic and molecular genetic evidence.

show abstract

“…Many studies demonstrated that neither chemotherapy alone nor radiotherapy alone was sufficient therapy for RIS [18,30,87,88]. Complete surgical excision was critical [89], specifically, wide local excision with negative surgical margins, either by segmental or total mastectomy. Positive margins had a significantly higher risk for local recurrence [28,30,90].…”

Section: Treatmentmentioning

confidence: 99%

“…In all RIA patients, a total mastectomy should be performed expediently after the diagnosis [63,84,89,95,96]. Colville et al [97] recommended a margin of 5 cm.…”

Section: Treatmentmentioning

confidence: 99%

Radiation-Induced Sarcoma of the Breast: A Systematic Review

et al. 2012

View full text Add to dashboard Cite

After completing this course, the reader will be able to:1. Evaluate the level of evidence to inform decision making for the treatment radiation induced sarcoma of the breast.2. Explain diagnostic criteria for radiation-induced sarcoma.3. Describe the effectiveness of surgery, chemotherapy and radiation therapy for radiation induced sarcoma of the breast.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACTIntroduction. Radiation-induced sarcoma (RIS) is a rare, aggressive malignancy. Breast cancer survivors treated with radiotherapy constitute a large fraction of RIS patients. To evaluate evidenced-based practices for RIS treatment, we performed a systematic review of the published English-language literature. Methods. We performed a systematic keyword search of PubMed for original research articles pertaining to RIS of the breast. We classified and evaluated the articles based on hierarchal levels of scientific evidence.Results. We identified 124 original articles available for analysis, which included 1,831 patients. No randomized controlled trials involving RIS patients were found. We

show abstract

Radiation-induced sarcoma: 25-year experience from The Norwegian Radium Hospital

Cited by 98 publications

References 30 publications

Radiation-induced sarcoma masquerading as osteoradionecrosis: case report and literature review

Radiation-induced sarcoma masquerading as osteoradionecrosis: case report and literature review

Sclerosing Rhabdomyosarcoma: Report of a Case Arising in the Head and Neck of an Adult and Review of the Literature

Radiation-Induced Sarcoma of the Breast: A Systematic Review

Contact Info

Product

Resources

About