Pleomorphic hyalinizing angiectatic tumor of soft parts: Case Report with unusual ganglion-like cells and review of the literature

Changchien, Yi Che; Bocskai, Pál; Kovács, Ilona; Hargitai, Zoltán; Kollár, Sándor; Török, Marietta

doi:10.1016/j.prp.2014.04.016

Cited by 10 publications

(15 citation statements)

References 18 publications

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“…Pleomorphic hyalinizing angiectatic tumors are a rare group of tumors first reported 2 decades ago by Smith et al [1] , [2] Since its first report, less than 100 cases have been documented [3] , [4] . We report a case that presented as a groin mass with a view to add to the body of evidence on this rare tumor which will guide accurate diagnosis and management.…”

Section: Introductionmentioning

confidence: 99%

Pleomorphic hyalinizing angiectatic tumor arising in the groin: A case report

Onyemkpa

Oyasiji

2016

International Journal of Surgery Case Reports

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Section: Introductionmentioning

confidence: 99%

Pleomorphic hyalinizing angiectatic tumor arising in the groin: A case report

Onyemkpa

Oyasiji

2016

International Journal of Surgery Case Reports

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“…1 Fewer than 100 cases have been reported to date; the largest series included 41 cases. 1,[10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] PHATs mainly occur in adults of both sexes during their fifth or sixth decade of life (range, 10-86 years). Tumor sizes range from 0.3 to 19.7 cm.…”

Section: Pleomorphic Hyalinizing Angiectatic Tumors Of Soft Partsmentioning

confidence: 99%

“…Both spindle and pleomorphic tumor cells are consistently positive for vimentin, with varied expression of CD34, factor XIIIa, VEGF, and CD99, but are negative for S100 protein, cytokeratin, desmin, epithelial membrane antigen, smooth muscle actin, HMB-45, MyoD1, p63, and CD31 (determined by immunohistochemistry). 11,12,14,15 Tu-mor cells have low proliferative indices, which are determined by either Ki-67 positivity (1%-3%) or percentage of S-phase cells, measured via immunohistochemistry or flow cytometry, respectively. Most Ki-67 þ cells are large and pleomorphic.…”

Section: Pleomorphic Hyalinizing Angiectatic Tumors Of Soft Partsmentioning

confidence: 99%

“…However, pleomorphic cells in some cases of PHAT were morphologically compatible with the pseudolipoblasts or virocyte-like cells or Reed-Sternberg-like cells in MIFS. 12,20,50,51 The stroma components of these tumors demonstrate large variation. HFLT is characterized by prominent mature adipocytes and marked hemosiderin deposition.…”

Section: The Intertwined Relationship Between Phat Hflt and Mifsmentioning

confidence: 99%

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The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor

Liu

Sukov

2018

Archives of Pathology &Amp; Laboratory Medicine

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- Diagnosis of HFLT, PHAT, and MIFS is challenging because of a lack of unique morphologic, immunophenotypic, molecular, and cytogenetic markers. The recurrent t(1;10)(p22;q24) translocation and/or TGFBR3/MGEA5 rearrangement was reported in 55 patients, with a relatively even distribution among HFLT, PHAT, and MIFS (17 HFLT, 15 MIFS, 13 MIFS/HFLT, and 10 PHAT). This indicates that current morphology-based diagnostic criteria do not identify reliably the subset of soft tissue tumor with t(1;10) translocation. Genetic heterogeneity of these tumors is supported by the recent detection of a mutually exclusive, second recurrent genetic change, t(7;17) TOM1L2-BRAF translocation or BRAF amplification, in a subset of MIFS.

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“…8 To date, it is estimated that less than 100 cases have been reported worldwide. 2 PHATs are non-metastasizing soft-tissue tumors, categorized as "tumors of uncertain differentiation" based on the 2013 World Health Organization classification. 11 They most frequently occur within the superficial subcutaneous tissues and in muscles.…”

Section: Introductionmentioning

confidence: 99%

Pleomorphic Hyalinizing Angiectatic Tumor Arising in the Hand

Kane

Gaspar

Whiting

et al. 2016

Hand (New York, N,Y.)

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Background: Background: Pleomorphic hyalinizing angiectatic tumors (PHATs) are extremely rare, non-metastasizing tumors of uncertain origin that are typically seen in the lower extremities. To date, it is estimated that less than 100 cases have been reported worldwide since first described in 1996. Methods: The case of a 35-year-old male with a several-year history of a dorsal hand mass is presented. Although the patient was initially asymptomatic, in the months prior to presentation, the patient complained of pain with power grasp and direct pressure over the mass. The patient underwent uncomplicated surgical excision, during which the mass was noted to be adherent to the underlying extensor tendons. Results: Immunopathology confirmed the mass to be PHAT. We believe this is the first documented case of this rare tumor occurring in the hand. Conclusions: History and epidemiology of PHAT are reviewed. Then, in the context of the presented case, pre-operative evaluation, surgical management, pathologic findings and post-operative follow-up are all discussed.

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Pleomorphic hyalinizing angiectatic tumor of soft parts: Case Report with unusual ganglion-like cells and review of the literature

Cited by 10 publications

References 18 publications

Pleomorphic hyalinizing angiectatic tumor arising in the groin: A case report

Pleomorphic hyalinizing angiectatic tumor arising in the groin: A case report

The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor

Pleomorphic Hyalinizing Angiectatic Tumor Arising in the Hand

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