Pleomorphic hyalinizing angiectatic tumor arising in the groin: A case report

Abstract

HighlightsPleomorphic Hyalinizing Angiectatic Tumors are rare tumors.Diagnosis is best with microscopic and histochemical analysis.Treatment is with wide local resection.

Pelvic retroperitoneal pleomorphic hyalinizing angiectatic tumor: A case report and review of literature

“…Imaging features of PHAT are not focused in the literature, and there are few reports about this issue. It is mostly described with soft tissue lesions without calcification 4 , 13 , 14 ; however, CT imaging of our patient illustrated some calcified components in the mass.…”

“…By immunohistochemistry, the cells of PHAT express CD34 and vimentin but are negative for actins, desmin, cytokeratin, EMA, von Willebrand factor, and CD31. 8 , 14 However, these findings are not specific for its diagnosis.…”

“…Examples of such tumors include low grade malignant fibrous histiocytoma, ancient schwannoma, cellular angiofibroma, solitary fibrous tumor, gastrointestinal stromal tumor, undifferentiated pleomorphic sarcoma, and hemosiderotic fibrolipomatous tumor. 14,15 For differentiation of these tumors, combinations of pathologic examination and immunohistochemical stains are used . 5,16,17 Imaging features of PHAT are not focused in the literature, and there are few reports about this issue.…”

Imaging and histological appearance of pleomorphic hyalinizing angiectatic tumors: A case series and literature review

“…PHAT typically presents in the subcutaneous tissues of the lower extremities, but may also develop intramuscularly, and has been documented in the arm, axilla, back, buccal mucosa, buttock, chest, hand, perineum, popliteal fossa and retroperitoneum ( 2 , 3 , 13 , 21 ). The most common locations of PHATs, based on the published literature, include the leg (18/97; 18.6%), thigh (17/97; 17.5%), foot (14/97; 14.4%) and the ankle (10/97; 10.3%) ( 1 – 41 ). PHAT typically presents in adults; the cases presented in the published literature (97 patients) range in age from 10–89 years, with a median age of 57.…”

“…No information is currently available concerning race and, as <10% of reported cases include this metric, no claims can be made regarding a predilection. Table I presents a list of all previously published cases of PHAT, including data on age, sex, race, tumor size, location and treatment ( 1 , 2 , 4 , 5 , 8 – 41 ).…”