Pleomorphic basal cell carcinoma

García, José Félix Sastre; Cohen, Philip R.; Herzberg, Arlene J.; Wallis, Mary E; Rapini, Ronald P.

doi:10.1016/0190-9622(95)91452-8

Cited by 37 publications

(21 citation statements)

References 20 publications

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“…Basaloid squamous BCC is diagnosed accurately when areas of basal cell and squamous carcinomas are noted with a minimum area of mixture between the two (6,32). Pleomorphous (basal cell carcinomas with monster cells) BCCs exhibit characteristics of the nodular basal cell type, while nuclear aneuploidy is considered a marker of histological aggressiveness (33). In our study, basal cell carcinomas with inflammatory infiltrates presented a recurrence rate of 48.2%, a finding that is in disagreement with other reports.…”

Section: Discussioncontrasting

confidence: 57%

Facial basal cell carcinoma: Analysis of recurrence and follow-up strategies

Sartore

Lancerotto²,

Salmaso³

et al. 2011

Oncol Rep

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Abstract. Rates of recurrence after incomplete surgical excision of basal cell carcinoma (BCC) range from 4 to 16.6% of analyzed cases. The aim of the present study was to identify the predictive factors associated with facial BBC recurrence following excision and their influences, in order to establish a proper therapeutic strategy. A monocentric retrospective study was performed reviewing all BCCs surgically excised at the Institute of Plastic Surgery, University of Padua, with particular focus on the involvement of surgical margins and recurrence. Seven hundred and nineteen lesions in 605 patients were studied. Correlations between recurrence probability and various characteristics of BCC were analyzed using a logistic regression model. It was observed that incomplete excision, deep margin involvement, the presence of sclerodermiform or metatypic basaloid squamous cells, as well as pleomorphous histological variants and/or peritumoral inflammatory infiltrates, were all related to an increase in the probability of recurrence. BCC excision must be followed by individualized management with particular consideration for the localization, the histological type and other known predisposing factors; the treatment strategy and, in particular, the length of the surveillance period and the frequency of patient assessment should be evaluated on the basis of the recurrence probability outlined.

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Section: Discussioncontrasting

confidence: 57%

Facial basal cell carcinoma: Analysis of recurrence and follow-up strategies

Sartore

Lancerotto²,

Salmaso³

et al. 2011

Oncol Rep

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“…48 Typically, these mis-shapen giant nuclei are either scattered individually through tumor lobules or show clustering suggesting that they are components of a similar clone ( Figure 13). All cases evaluated by static image analysis cytometry have proven to be aneuploid 49 but paradoxically, mitoses, although present with roughly the same frequency as seen in typical nodular BCCs, are not often atypical. 48,49 As these pleomorphic monster cells impart no prognostic significance from the standpoint of enhanced biological aggressiveness, we speculate that this represents a form of senescent atypia.…”

Section: Follicular Bccmentioning

confidence: 91%

“…These include, but are not restricted, to keratotic BCC, 39 infundibulocystic BCC (Figure 12), 42,43 follicular BCC, [44][45][46][47] which shows collision features with pilomatricoma, pleomorphic BCC ( Figure 13), 48,49 BCC with eccrine differentiation, [50][51][52] BCC with sebaceous differentiation, the fibroepithelioma of Pinkus (Figure 14), 53 and the BCC with myoepithelial differentiation. 54 Keratotic BCC Also known as pilar BCC as it appears to differentiate along pilosebaceous lines, the keratotic BCC manifests large basaloid tumor nests that are rounded and show central keratinization and degeneration.…”

Section: Introductionmentioning

confidence: 99%

Basal cell carcinoma: biology, morphology and clinical implications

2006

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Basal cell carcinoma (BCC) is the most common malignant neoplasm of humans. Rising dramatically in incidence in North America, as likely reflects changing habits of the population and a move from more northerly climes to the sunbelt of the Southern and Southwestern United States, the incidence is surely to rise even higher in the future. The last decade has seen significant advances in our understanding of BCC biology and novel approaches to therapy, which hinge upon accurate diagnosis and subclassification by pathologists. The purpose of this review article is to summate the research advances in our understanding of BCC biology and to acquaint pathologists and clinicians to the practical issues in BCC diagnosis and subclassification which flow there from.

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“…DNA aneuploidy may be associated with pleomorphic BCC and was not associated with an aggressive clinical course. 44 The manner of specimen collection, patient selection, and variability in sample processing as well as the use of paraffin embedded material may have accounted for differences in findings between this study and other^.^',^^ For instance, in other studies, the use of only mechanical disruption may have yielded cells whose cell-to-cell adhesions were weak, thus selecting for more poorly differentiated cell types that were more likely to be aneuploid. Prior flow cytometric analyses of head and neck SCC using paraffin embedded m a t e~i a l~~-~* have noted the difficulty in dispersing epidermal cells that are interconnected by desmosomal attachments and proposed a variety of methods for enzymatically solubilizing the intercellular matrix to enhance recovery of viable cell^.…”

Section: Discussionmentioning

confidence: 88%

DNA ploidy in nonmelanoma skin cancer

Robinson

Rademaker

Goolsby

et al. 1996

Cancer

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The measurement of DNA ploidy of well differentiated squamous cell carcinoma, and proliferative capacity or S-phase of both basal cell and squamous cell carcinomas assists in predicting the biologic proclivity for locoregional invasion or metastasis of nonmelanoma skin cancer. Identification of aggressive tumors at the time of surgery may offer the opportunity for prevention of lethal metastasis by using adjunctive therapy.

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Pleomorphic basal cell carcinoma

Cited by 37 publications

References 20 publications

Facial basal cell carcinoma: Analysis of recurrence and follow-up strategies

Facial basal cell carcinoma: Analysis of recurrence and follow-up strategies

Basal cell carcinoma: biology, morphology and clinical implications

DNA ploidy in nonmelanoma skin cancer

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