Pleomorphic adenoma of the salivary glands in children and adolescents

Fu, Honghai; Wang, Jun; Wang, Lizhen; Zhang, Zhiyuan; He, Yue

doi:10.1016/j.jpedsurg.2011.10.067

Cited by 32 publications

(39 citation statements)

References 32 publications

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“…PA are rare in children and adolescents, accounting for approximately 2 % of all salivary gland tumors [18,129], in contrast to their commonality (65 % of all salivary neoplasms) in adults [130]. Composite analysis of a number of studies reveals the majority (62 %; range 56-77 %) to occur in the parotid gland, with the submandibular gland (26 %; range 11-40 %) and the minor salivary glands (12 %; range 0-21 %) being comparatively less frequents sites of origin [12,19,25,26,28,29,129].…”

Section: Pleomorphic Adenomamentioning

confidence: 99%

“…Composite analysis of a number of studies reveals the majority (62 %; range 56-77 %) to occur in the parotid gland, with the submandibular gland (26 %; range 11-40 %) and the minor salivary glands (12 %; range 0-21 %) being comparatively less frequents sites of origin [12,19,25,26,28,29,129]. Similar to adults, a female predominance has been documented with an approximate 1.4:1 female to male ratio [129]. The typical presentation is a slow growing mass with an average duration of symptoms prior to presentation of approximately 12 months [18,129].…”

Section: Pleomorphic Adenomamentioning

confidence: 99%

“…Similar to adults, a female predominance has been documented with an approximate 1.4:1 female to male ratio [129]. The typical presentation is a slow growing mass with an average duration of symptoms prior to presentation of approximately 12 months [18,129]. Pain is a rare symptom and, when present, often implies tumor necrosis [131].…”

Section: Pleomorphic Adenomamentioning

confidence: 99%

“…The relative amounts of cellular and stromal tissue have no bearing on the aggressiveness of the tumor [133].The optimal treatment of PA is wide surgical excision with negative margins. The preferred treatment for parotid lesions is superficial parotidectomy or total parotidectomy depending on lesion location [129]. This approach yields local control rates in excess of 95 % [135].…”

Section: Pleomorphic Adenomamentioning

confidence: 99%

See 3 more Smart Citations

Salivary Gland Tumors

Lennon

Cunningham

2013

Pediatric Head and Neck Tumors

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Section: Pleomorphic Adenomamentioning

confidence: 99%

Section: Pleomorphic Adenomamentioning

confidence: 99%

Section: Pleomorphic Adenomamentioning

confidence: 99%

Section: Pleomorphic Adenomamentioning

confidence: 99%

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Salivary Gland Tumors

Lennon

Cunningham

2013

Pediatric Head and Neck Tumors

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“…Nevertheless the most common epithelial tumors of the major salivary glands in children and adolescents are pleomorphic adenomas (PA) [2]. However, few authors have reported the various pathological characteristics of major salivary gland tumors in children as well as adolescents and adults [3].…”

Section: Introductionmentioning

confidence: 99%

Comparison between immunohistochemical expression of Ki-67 and MCM-3 in major salivary gland epithelial tumors in children and adolescents. Preliminary study

Zieliński¹,

Kobos²,

Zakrzewska³

2016

pjp

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While Ki-67 expression is frequently used as an indicator of tumor cell proliferation, alternative markers have also been proposed. Possible alternative indicators of proliferation are the minichromosome maintenance (MCM) proteins, whose levels are inversely associated with tumor cell differentiation. The aim of this preliminary study was to compare the levels of Ki-67 and MCM-3 expression in major salivary gland epithelial tumors in all children and adolescents who underwent surgery in our department in the years 2009-2014. The histopathological diagnosis of the subjects was reviewed, as well as the expression of Ki-67 and MCM-3 in post-op specimens of the tumors. The normality of data was checked with the Shapiro-Wilk test. The t test for independent variables or the U test was used as appropriate to determine statistically significant differences in the expression of Ki-67 and MCM-3. Five cases of pleomorphic adenoma, one of myoepithelioma, one of basal cell adenoma and one of mucoepidermoid carcinoma were identified. Significantly greater MCM-3 than Ki-67 expression was observed in every case. The results of our preliminary study emphasize the need for future research on MCM-3 as a sensitive proliferation marker, providing an alternative to Ki-67, in cases of various major salivary gland epithelial tumors in children and adolescents.

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The application of current classification systems in pediatric cytopathology: Perspectives from the pediatric cytopathology symposium at the 20th International Congress of Cytology 2019

Baloch

Rossi

Teot

et al. 2019

Cancer Cytopathology

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A pediatric cytopathology symposium was held at the recent 20th International Congress of Cytology, which convened in Sydney, Australia, in May 2019. This educational event brought together cytopathologists from different countries and different institutions to discuss some of the practical considerations when applying current diagnostic classification systems to cytopathology specimens from young (pediatric and adolescent) patients. Within the past decade, various classification systems have been developed to create more standardized terminology for cytopathology specimen reporting among institutions, which can lead to improved management guidelines based on evidence‐based medicine. It is well known that a majority of the peer‐reviewed publications in cytopathology discussing the usefulness of these classification schemes predominantly contain case cohorts of adult patients. Although pediatric cases are not excluded from following these diagnostic guidelines, there is less of an emphasis on this age group with respect to unique findings and management differences. Thus, discussing the role of these guidelines and their applications in pediatric cases at an international educational gathering can not only be beneficial in educating the cytopathology community about the value of applying these classification systems to pediatric populations, but also can raise awareness of unique entities in cytologic specimens obtained from young patients.

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Pleomorphic adenoma of the salivary glands in children and adolescents

Cited by 32 publications

References 32 publications

Salivary Gland Tumors

Salivary Gland Tumors

Comparison between immunohistochemical expression of Ki-67 and MCM-3 in major salivary gland epithelial tumors in children and adolescents. Preliminary study

The application of current classification systems in pediatric cytopathology: Perspectives from the pediatric cytopathology symposium at the 20th International Congress of Cytology 2019

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