Pleomorphic adenoma of the nose

Mathur, D. R.; Vyas, M. C. R.; Vyas, Neerja; Remdeo, I. N.

doi:10.1007/bf02994928

Cited by 2 publications

(1 citation statement)

References 2 publications

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“…However, its highly hydrophobic chemical structure resulted in reducing potential in medical application. Markedly, nanocarriers applying to herbal regiments will be expected to carry optimum amount of the drug to their site of action bypassing all the barriers and increase the prolonged circulation of the drug into the blood due to their small size [32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Poly (N-isopropylacrylamide)-functionalized dendrimer as a thermosensitive nanoplatform for delivering malloapelta B against HepG2 cancer cell proliferation

Pham

Nguyen

et al. 2017

Adv. Nat. Sci: Nanosci. Nanotechnol.

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In recent years, nanocarriers have emerged as effective platforms for delivering several kinds of herbal medicine and naturally bioactive compounds. In this study we developed an outstanding thermosensitive dendritic nanocarrier to efficiently deliver malloapelta B (Mall B), which is a water insoluble bioactive compound isolated from leaves of Mallotus apelta-Vietnamese medicinal plant. The thermosensitive poly(N-isopropylacrylamide) (PNIPAM) polymer-conjugated polyamidoamine (PAMAM) dendrimer copolymer was prepared via Michael reaction. The copolymer structures were confirmed by proton nuclear magnectic resonance ( 1 H NMR). Morphology of the nanocarrier was observered around 70-120 nm by transmission electron microscopy (TEM). Size distributions were measured by dynamic light scattering (DLS) of the nanocarrier and its Mall B-loaded performed at 146.8 nm and 194.5 nm, respectively. The PNIPAM-g-PAMAM-based nanocarrier exhibited higher Mall B loading efficiency (DL = 59.93 ± 0.19%) and entrapment efficiency (EE = 89.98 ± 2.06%) as compared to PNIPAM (DL = 52.54 ± 0.45% and EE = 66.45 ± 2.78%). In vitro release indicated that approximately 30% amount of the loaded Mall B released at pH 5.5 after 54 h tracking. At the same time, 12.5% amount of the molecules released at pH 7.4.Cytotoxicity assay results showed that the Mall B-loaded nanocarrier significantly inhibited HepG2 cancer cell proliferation. These obtained results indicated that the nanocarrier could solve hydrophobic property of Mall B for further medicine applications.

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Section: Introductionmentioning

confidence: 99%