Pleomorphic adenoma of the larynx

Argat, M; Ia, Born; Maier, H.; Mohadjer, C.

doi:10.1007/bf00181891

Cited by 6 publications

(5 citation statements)

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“…The existence of adenocarcinomatous and chondrosarcomatous areas in the lymph node metastasis indicates that this laryngeal malignant mixed tumor originated in the seromucous glands of the larynx. Moreover, this hypothesis is consistent in part with the origin of the malignant mixed tumor in the salivary gland, 21 because some malignant mixed tumors of the salivary gland also arose in a previously pleomorphic adenoma 22 (a so-called benign mixed tumor). The histogenesis of malignant mixed tumor of the larynx is not well established; however, in the major salivary glands, the origin of this tumor has been related to a proliferation of myoepithelial cells, which have been considered as totipotent precursor cells.…”

Section: Discussionmentioning

confidence: 54%

Malignant mixed tumor of the larynx

et al. 2005

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Section: Discussionmentioning

confidence: 54%

Malignant mixed tumor of the larynx

et al. 2005

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“…As per the literature, the prognosis of adenoid cystic carcinoma of the submandibular gland is good with early diagnosis, extensive surgical intervention, and postoperative radiotherapy. Adverse prognosis is associated with presentations with an advanced tumor, positive surgical margins, and perineural invasion [ 18 ]. Three of our patients with pleomorphic adenoma of the palate on FNAC had CT features showing cystic components with significant lymph nodes, and the intraop frozen section showed low-grade malignancy.…”

Section: Discussionmentioning

confidence: 99%

Extra-Parotid Pleomorphic Adenoma and Low-Grade Salivary Malignancy in the Head and Neck Region

Jose¹,

Mohiyuddin²,

Mohammadi³

et al. 2023

Cureus

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Background and objectivePleomorphic adenoma is the most common major salivary gland neoplasm. Around 80% of them arise in the parotid glands, whereas 10% originate in the minor salivary glands. The pleomorphic adenoma of the extraparotid site is defined by its location outside the primary salivary gland. The minor salivary gland adenomas occur at the hard and soft palate, lips, tongue, lacrimal glands, pharynx, larynx, paranasal sinus, and nasal cavity. Pleomorphic adenoma in parapharyngeal space may occur de novo or as an extension of the deep lobe of the parotid tumors. Our objective in this study was to assess the location and presentations of extraparotid pleomorphic adenoma and frequency of low-grade salivary gland malignancy diagnosed as pleomorphic adenoma via fine-needle aspiration cytology (FNAC) in the head and neck region and the treatment outcomes after the resection of the tumors. Materials and methodsThis was a retrospective observational study. All patients with FNAC-diagnosed pleomorphic adenoma of extra-parotid locations of the head and neck region who underwent curative surgery in the Department of Otorhinolaryngology and Head and Neck Surgery at a rural tertiary care center between August 1997 and August 2022 were included in the study. Data on the symptoms, FNAC report, surgical techniques, pathological results, adjuvant therapy, and any recurrence were documented. Data were entered into a Microsoft Excel sheet and analyzed using IBM SPSS Statistics version 22 software (IBM Corp., Armonk, NY). ResultsOur study included 23 patients, of which 14 were females and nine were males. The various sites of involvement were as follows: parapharyngeal space (four), larynx (one), nasal septum (two), hard palate (five), soft palate (four), hard and soft palate (three), and submandibular salivary gland (four). Of note, 17.3% of the patients had local recurrence with an average time frame of three years post-surgery: 20% in patients with low-grade malignancy and 16.6% in patients with pleomorphic adenoma. ConclusionExtra-parotid pleomorphic adenomas are common and have a high malignant potential. The preferred choice of treatment for extra-parotid salivary tumors is complete resection with adequate clearance. Malignant pleomorphic adenomas may require staging neck dissection and adjuvant treatment for a better prognosis.

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“…A review of the world literature revealed 14 cases involving a pleomorphic adenoma of the larynx 12–15 . But only one case of pleomorphic adenoma of the posterior commissure has been reported 13 . We describe here a rare case of pleomorphic adenoma of the posterior laryngeal commissure with a favorable prognosis.…”

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confidence: 82%