Pleiotropic Genes Affecting Carcass Traits in Bos indicus (Nellore) Cattle Are Modulators of Growth

Milanesi

et al. 2017

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The recent evolution of cattle is marked by fluctuations in body size. Height in the Bos taurus lineage was reduced by a factor of ~1.5 from the Neolithic to the Middle Ages, and increased again only during the Early Modern Ages. Using haplotype analysis, we found evidence that the bovine PLAG1 mutation (Q) with major effects on body size, weight and reproduction is a >1,000 years old derived allele that increased rapidly in frequency in Northwestern European B. taurus between the 16th and 18th centuries. Towards the 19th and 20th centuries, Q was introgressed into non-European B. taurus and Bos indicus breeds. These data implicate a major role of Q in recent changes in body size in modern cattle, and represent one of the first examples of a genomic sweep in livestock that was driven by selection on a complex trait.

Section: Introductionmentioning

confidence: 57%

A PLAG1 mutation contributed to stature recovery in modern cattle

Milanesi

et al. 2017

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“…To the authors knowledge, there is no comparable experimental information about the performance of adult animals in the study region, but it supports, the limited number of available on ranch observations. Thus, given the fact that irrespective of the year, all studied cattle were subject to a similar commercial management considerations, differences in LW performance most likely reflects a variability and/or interaction amongst environmental conditions (Domínguez et al 2003;; growth traits, including compensatory gains (Hernández-Hernández et al 2015); genetic parameters and their interacting networks (Ceacero et al 2016;Lopes et al 2013;Pereira et al 2016); hormones secretion (Kasuya 2016; Widmann et al 2013); maternal effects (Neidhardt et al 1979); grazing management (Vera and Ramírez-Restrepo 2017); diet selection (O'Neill et al 2013); nutritive and metabolic trigger factors in the forage resources (Tedeschi et al 2014); and the adaptive capacity of Brahman and Belmont Red Composite to respond to those triggers within a climate change environment (Ramírez-Restrepo and Charmley 2015). In parallel, a particularly relevant aspect is that putting weight on cull cows in thin to medium condition has been found to be more profitable than cows with higher body scores (Amadou et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Bodyweight performance, estimated carcass traits and methane emissions of beef-cattle categories grazing Andropogon gayanus, Melinis minutiflora and Stylosanthes capitata mixed swards and Brachiaria humidicola pasture

Ramírez-Restrepo

Vera

2019

Anim. Prod. Sci.

Cow–calf operations constitute the main land-use system in the 18 million ha of well drained tropical savannas of Colombia located in the Orinoco basin. There, numerous sex and age animal categories are present, ranging from suckling calves to old cull cows and steers, which in variable proportions are stocked at one animal unit (AU)/5–10 ha, depending on the ranch and distance from markets. In parallel, early-on farm observations showed that when sown pastures are introduced, graziers recur to opportunistic partial fattening of cull animals for a rapid economic return. The paper reports animal weight gains of cull cows, old steers, and young heifers and yearlings over seven consecutive years grazing on a low fertiliser-input well managed Andropogon gayanus-based pasture and four contemporary years on Brachiaria humidicola. The first 2 years involved three stocking rates (SR; 1.38, 1.85 and 2.32 animal units/ha), whereas a single SR of 1.33 animal units/ha was used for the remainder. A large database that included chemical, and in vitro and in vivo digestibility, values for all forages involved, was used as an input to a mathematical model to estimate methane (CH4) emissions. Estimations were compared with weight-based predictions derived from chamber measurements recorded recently in tropical Australia. Faecal mineral concentration varied little (not significantly) among SR and animal categories. Weight gains of old steers were 4–24% larger than those of cull cows, which, in turn, were larger than those of young steers and heifers (P < 0.01). Excepting one year, the performance of cull cows and old steers did not differ between pastures, confirming earlier on-ranch observations of reasonable weight gains of adult cattle on both pastures. The predicted carcass composition of cull cows and old steers did not differ between pastures either. Over the length of the experiment, cull cows emitted significantly less CH4 than did old steers (129 vs 141 g/day) on A. gayanus, while emissions on B. humidicola amounted to 128 and 137 g/day respectively. Despite between-year differences in animal performance, they are indicative of well managed pasture sustainability. They also show some of the trade-offs involved in the use of contrasting animal categories and pastures in terms of weight performance and predicted carcass composition and CH4 production. The authors expect that the present results will contribute to a rational, science-based discussion of the role of beef systems vis-à-vis environment in a region with limited production alternatives.

“…7). Previous QTLs studies detected genomic regions on BTA 2 and 14 play an important role in multiple traits ( Supplementary Table S2) 74,[78][79][80][81] . These genomic regions are known to act on age at puberty, calving to conception interval, the interval from first to last insemination, body weight and intramuscular fat ( Supplementary Table S2).…”

Section: Shared Regions Surround Genes For Afc On Low Medium and Higmentioning

confidence: 99%

Genome-wide scan highlights the role of candidate genes on phenotypic plasticity for age at first calving in Nellore heifers

Mota

Lopes²,

Júnior

et al. 2020

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Age at first calving (AFC) plays an important role in the economic efficiency of beef cattle production. This trait can be affected by a combination of genetic and environmental factors, leading to physiological changes in response to heifers' adaptation to a wide range of environments. Genomewide association studies through the reaction norm model were carried out to identify genomic regions associated with AFC in Nellore heifers, raised under different environmental conditions (EC). The SNP effects for AFC were estimated in three EC levels (Low, Medium, and High, corresponding to average contemporary group effects on yearling body weight equal to 159.40, 228.6 and 297.6 kg, respectively), which unraveled shared and unique genomic regions for AFC in Low, Medium, and High EC levels, that varied according to the genetic correlation between AFC in different EC levels. The significant genomic regions harbored key genes that might play an important biological role in controlling hormone signaling and metabolism. Shared genomic regions among EC levels were identified on BTA 2 and 14, harboring candidate genes associated with energy metabolism (IGFBP2, IGFBP5, SHOX, SMARCAL1, LYN, RPS20, MOS, PLAG1, CHCD7, and SDR16C6). Gene set enrichment analyses identified important biological functions related to growth, hormone levels affecting female fertility, physiological processes involved in female pregnancy, gamete generation, ovulation cycle, and age at puberty. the genomic regions highlighted differences in the physiological processes linked to AFC in different EC levels and metabolic processes that support complex interactions between the gonadotropic axes and sexual precocity in nellore heifers. open Scientific RepoRtS | (2020) 10:6481 | https://doi.org/10.1038/s41598-020-63516-4 www.nature.com/scientificreports www.nature.com/scientificreports/ pathway and gene network analyses from these results can be performed to uncover mechanisms whereby the environment can potentially affect the sexual precocity in cattle. Such knowledge regarding genomic regions and biological pathways involved with GxE interactions in Nellore heifers' sexual precocity is important to identify molecular mechanisms underlying the phenotypic responses to different environments. Hence, this study was carried out to evaluate the changes in the SNP effect estimates, as well as the biological processes associated with age at first calving in three environmental conditions, combining RN models and GWAS. Materials and Methodsethics approval. The animal procedures in this study were approved by Animal Care of the São Paulo State University (UNESP), School of Agricultural and Veterinary Science Ethical Committee (protocol number 18.340/16). All the data sampling was performed in accordance with CEUA/ FCAV-UNESP guidelines and regulations.phenotypic and genotypic data. Age at first calving (AFC) records were obtained from 185,356Nellore heifers belonging to three commercial breeding programs (DeltaGen, Paint -CRV Lagoa and Cia de Melhoramento), which are p...