Pleiotropic effects of regular lipoprotein-apheresis

Sinzinger, H.; Steiner, Sabine; Derfler, Kurt

doi:10.1016/j.atherosclerosissup.2017.05.032

Cited by 13 publications

(11 citation statements)

References 24 publications

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“…Lipoprotein apheresis as the most effective treatment for FH patients is a method to selectively remove lipoproteins containing ApoB components from patients' plasma. LA cannot just reduce high LDL‐C concentration and/or Lp(a) levels, but also effectively alleviate clinical symptoms and signs of FH patients . In addition, LA treatment is recognized as safe and can improve the prognosis of patients with progressive CVD .…”

Section: Introductionmentioning

confidence: 99%

Improvement of oxidative stress status by lipoprotein apheresis in Chinese patients with familial hypercholesterolemia

Wen

Dong

et al. 2019

Clinical Laboratory Analysis

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Background and aims: Familial hypercholesterolemia (FH) characterized by severe high blood cholesterol levels usually presents an imbalance of systemic oxidative stress(OS).Lipoproteinapheresis(LA),whichisthemosteffectivetherapytoreduce cholesterollevels,remainsunclearinalteringOSandscarceinChinesepatientstudies. OurstudyaimstoassesstheimpactofLAonOSstatusinChinesepatientswithFH.Methods: About31patients(22males,age:12-69years)withFHandreceivingLA treatment were consecutive enrolled. Free oxygen radicals test (FORT) and free oxygen radicals defense (FORD) values were determined using the free oxygen radical monitor and kit immediately before and after LA, while blood samples were collected to measure plasma lipid levels and hs-CRP by conventional methods. Data were analyzed by paired ttestorranksumtestandSpearman-rhocorrelationanalysis.Results: Besides plasma lipid levels, the OS status showed that FORTs were significantly decreased and FORD values significantly enhanced immediately after LA treatment compared with before (both P < .01). In addition, the correlation analysis showed that the removal rates (△%) of TC were positively related to the increased rates (△%) of FORD value (ρ = 0.513, P = .003); LDL-C to FORD (ρ = 0.39, P = .03); Lp(a) to FORD (ρ=0.473,P=.007);andnon-HDL-CtoFORD(ρ = 0.46, P = .009). However,nosignificantdifferenceinhsCRPwasfound.Conclusions: The present study indicated, besides effectively lowering plasma lipid levels,LAcouldsignificantlyimproveOSstatusinChinesepatientswithFH. K E Y W O R D S familial hypercholesterolemia, lipoprotein apheresis, oxidative stressThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Section: Introductionmentioning

confidence: 99%

Improvement of oxidative stress status by lipoprotein apheresis in Chinese patients with familial hypercholesterolemia

Wen

Dong

et al. 2019

Clinical Laboratory Analysis

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“…It should be noted a number of important pleiotropic and non-lipid, anti-inflammatory and rheological effects during the selective lipid apheresis [37,[40][41][42] . Hibino et al [43] (2009) demonstrated anti-inflammatory and homeostasis-correcting effects of cascade rheofiltration.…”

Section: Discussionmentioning

confidence: 99%

The use of lipoprotein apheresis for the treatment of high-risk patients with elevated lipoprotein(a) and hypercholesterolemia

Yaroustovsky¹,

Abramyan²,

Rogalskaya³

et al. 2019

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Aim: To assess the safety and efficiency of H.E.L.P.-apheresis and cascade lipid-filtration in the treatment of severe lipid disorders in high-risk patients. Methods: From 2016 to 2018 we observed 6 patients hyperLDLemia and high Lp(a)emia (> 60 mg/dL). The first group with H.E.L.P.-apheresis (n = 74 sessions) included 3 patients who underwent revascularization (coronary, femoral arteries). In the second group with cascade lipid-filtration (n = 92 sessions)-one patients underwent revascularization, two patients received drug therapy. Despite the lipid-lowering conventional therapy, no targeted low density lipoprotein (LDL) was obtained. Results: The patients of the 1st group had threefold decrease of LDL, in patients of the 2nd group LDL decreased by 68%. At the same time, in both groups, we noted a decrease in Lp(a) after the procedure by 65%-68%. Despite a decrease in high density lipoprotein (by 22%-29%) after lipid apheresis procedures, there was a positive trend in apoB100/apoA index (a decrease of 33% after HELP-apheresis procedures and 60% after cascade lipid-filtration) and a decrease in atherogenic index (38% and 53%, respectively). The changes in hematological and haemostatic parameters remained within physiological intervals. Conclusion: We noticed the successful application of lipid apheresis in patients with multifocal atherosclerosis and its complications.

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“…Diese beeindruckenden klinischen Ergebnisse bei LA-Patienten scheinen im Widerspruch zu den eher mittelmäßigen durchschnittlichen Lp(a)-Absenkungen von 30-35 % unter chronischer LA zu stehen, obwohl die Lp(a)-Absenkungsraten unmittelbar nach den LA-Behandlungen bei mehr als 60-70 % liegen. Mittlerweile gibt zahlreiche Hinweise aus Studien, die zeigen, dass LA-Verfahren per se eben nicht nur LDL-Cholesterin/Lp(a) absenken, sondern erheblich in den gesamten In ammationsprozess der Atherosklerose eingreifen können [33]. Als Beispiel sei u. a. die Reduktion von C-reaktivem Protein (CRP) [34], aber auch Interleukin-1 , Interleukin-6 und TNF-genannt [35].…”

Section: Therapeutische Absenkung Von Lp(a)unclassified

Lp(a): der akzeptierte unabhängige Risikofaktor

Schettler¹

2019

Dialyse aktuell

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Lipoprotein(a) (Lp(a)) besteht aus einem LDL-Partikel, an dem über das Apolipoprotein B100 des Partikels eine Disulfidbrücke zu einem Apolipoprotein(a) besteht ( Abb. 1 ). Obwohl Lp(a) bereits 1963 von Berg et al. erstmals als „lipoprotein associated antigen“ entdeckt 1 und schon früh ein Zusammenhang mit kardiovaskulären Ereignissen diskutiert wurde 2, konnten diese Annahmen der klinischen Eigenschaften erst deutlich später im Rahmen von epidemiologischen Evaluationen bestätigt werden 3, 4. Ab einer Lp(a)-Konzentration von über 30 mg/dl (> 75 nmol/l) besteht ein nahezu linearer Zusammenhang zwischen dem Anstieg der Lp(a)-Konzentration und kardiovaskulären Ereignissen wie Myokardinfarkt und das Risiko für eine Aortenklappenstenose 3, 4.

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Pleiotropic effects of regular lipoprotein-apheresis

Cited by 13 publications

References 24 publications

Improvement of oxidative stress status by lipoprotein apheresis in Chinese patients with familial hypercholesterolemia

Improvement of oxidative stress status by lipoprotein apheresis in Chinese patients with familial hypercholesterolemia

The use of lipoprotein apheresis for the treatment of high-risk patients with elevated lipoprotein(a) and hypercholesterolemia

Lp(a): der akzeptierte unabhängige Risikofaktor

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