Platonin Improves Survival of Skin Allografts

Cheng, Shih‐Ping; Lee, Jie-Jen; Chi, Chin-Wen; Chang, Kuo-Ming; Chen, Yu-Jen

doi:10.1016/j.jss.2009.05.045

Cited by 5 publications

(2 citation statements)

References 41 publications

(47 reference statements)

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“…The 6-MITC induces G2/M phase arrest in cancer cells and is capable of blocking the KRAS/BRAF and PI3K/AKT signaling pathways [ 11 , 12 ]. Because the effect of these compounds on alloantigen recognition and T-cell activation are unknown, we established an experimental skin allograft model as a drug screen for immunosuppressants following transplantation [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Wasabi Component 6-(Methylsulfinyl)hexly Isothiocyanate and Derivatives Improve the Survival of Skin Allografts

Huang

Lin

et al. 2022

IJMS

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We tested the effect of 6-(Methylsulfinyl)hexyl Isothiocyanate (6-MITC) and derivatives (I7447 and I7557) on the differentiation and maturation of human myeloid dendritic cells (DCs) in vitro, and skin transplantation in vivo. Triggering of CD14+ myeloid monocyte development toward myeloid DCs with and without 6-MITC and derivatives to examine the morphology, viability, surface marker expression, and cytokine production. Stimulatory activity on allogeneic naive T cells was measured by proliferation and interferon-g production. The skin allograft survival area model was used to translate the 6-MITC and derivatives’ antirejection effect. All of the compounds had no significant effects on DC viability and reduced the formation of dendrites at concentrations higher than 10 mM. At this concentration, 6-MITC and I7557, but not I7447, inhibited the expression of CD1a and CD83. Both 6-MITC and I7557 exhibited T-cells and interferon-g augmentation at lower concentrations and suppression at higher concentration. The 6-MITC and I7557 prolonged skin graft survival. Both the 6-MITC and I7557 treatment resulted in the accumulation of regulatory T cells in recipient rat spleens. No toxicity was evident in 6-MITC and I7557 treatment. The 6-MITC and I7557 induced human DC differentiation toward a tolerogenic phenotype and prolonged rat skin allograft survival. These compounds may be effective as immunosuppressants against transplant rejection.

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Section: Introductionmentioning

confidence: 99%

Wasabi Component 6-(Methylsulfinyl)hexly Isothiocyanate and Derivatives Improve the Survival of Skin Allografts

Huang

Lin

et al. 2022

IJMS

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“…[3] DCs can be induced to di erentiate into a less mature stage or to acquire a tolerogenic phenotype. [4][5][6] is induced di erentiation suggests that modulation of DC development could have therapeutic potential in the treatment or prevention of diseases involving unwanted immune response, such as rejection of transplanted gra s. [7] Bisphosphonates have been widely used for treatment of excessive bone loss arising from increased number and activity of osteoclasts, such as that seen in osteoporosis from the aging process and bone metastasis from cancers. [8][9] Among various kinds of bisphosphonates, the nitrogen-containing bisphosphonates have been shown to inhibit farnesyl diphosphate synthase [10] and squalene synthase [11] of the mevalonate pathway, which interferes with protein prenylation of small GTPase to induce osteoclast apoptosis.…”

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confidence: 99%

Zoledronic acid, an aminobisphosphonate, prolongs survival of skin allografts

Liu¹,

Yang²,

Cheng³

et al. 2012

CIM

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Purpose: Zoledronic acid (ZOL), an effective nitrogen-containing bisphosphonate used to prevent excessive bone loss in clinical practice, has been shown to affect the development of dendritic cells by redirecting differentiation toward a state of atypical maturation. The study was aimed to examine whether ZOL can reduce acute rejection of skin allografts. Methods: A skin transplantation model using C57BL/6 to BALB/c mice was used. ZOL was injected intraperitoneally into transplant recipients post-surgically. Graft survival, body weight, leukocyte count, hepatic and renal functions were assessed. Results: ZOL treatment significantly prolonged skin allograft survival in mice. In terms of toxicity, there were no significant differences in body weight, leukocyte count, plasma alanine aminotransferase or creatinine levels between the ZOL-treated and control groups. Histopathology showed that the loss of skin integrity seen in control group was prevented by ZOL treatment. In draining lymph nodes and spleen, the number and clustering extent of mononuclear cells were markedly declined by ZOL treatment. The plasma IL-6 levels were reduced by treatment of ZOL. Conclusion: ZOL can prolong skin allograft survival without major toxicity.

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Expression and Biologic Significance of Adiponectin Receptors in Papillary Thyroid Carcinoma

Cheng

Liu

Hsu

et al. 2012

Cell Biochem Biophys

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Obesity is associated with a higher incidence of thyroid cancer. Adiponectin is one of the most abundant adipokines with a pleiotropic role in metabolism and in the development and progression of cancer. It has been shown that circulating adiponectin level is inversely associated with the risk of thyroid cancer. This study aimed to investigate the possible association between the expression of adiponectin receptors (AdipoR1 and AdipoR2) and clinicopathological variables in papillary thyroid cancer. We found that protein levels of AdipoR1 and AdipoR2 were increased in some thyroid cancer specimens compared with adjacent normal thyroid tissues. Thyroid cancer cells expressed AdipoR1 and AdipoR2, which were attenuated by histone deacetylase inhibitors valproic acid and trichostatin A. Adiponectin stimulated AMP-activated protein kinase phosphorylation in thyroid cancer cells. We further determined the expression of AdipoR1 and AdipoR2 by immunohistochemical staining in primary tumor samples and metastatic lymph nodes. AdipoR1 was expressed in 27 % of primary tumors and AdipoR2 in 47 %. Negative expression of both adiponectin receptors was significantly associated with extrathyroidal invasion, multicentricity, and higher TNM stage. There was a trend toward decreased disease-free survival in patients with negative tumor expression of AdipoR1 and AdipoR2 (log-rank P = 0.051). Collectively, overexpression of adiponectin receptors was observed in some tumor tissues of papillary thyroid cancer and was associated with a better prognosis.

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Platonin Improves Survival of Skin Allografts

Cited by 5 publications

References 41 publications

Wasabi Component 6-(Methylsulfinyl)hexly Isothiocyanate and Derivatives Improve the Survival of Skin Allografts

Wasabi Component 6-(Methylsulfinyl)hexly Isothiocyanate and Derivatives Improve the Survival of Skin Allografts

Zoledronic acid, an aminobisphosphonate, prolongs survival of skin allografts

Expression and Biologic Significance of Adiponectin Receptors in Papillary Thyroid Carcinoma

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