Platinum(II) complexes of nitroimidazoles: synthesis, characterisation, and X-ray crystal structures of cis-dichlorobis[1-(2′-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole]platinum(II) and trans-dichlorobis[1-(2′-hydroxy-3′-methoxypropyl)-2-nitroimidazole]platinum(II)

1-Methoxy-3-(2-nitro-1-imidazolyl)-2-propanol (misonidazole)

“…Bond lengths and angles in the side chain formed by atoms C ll to C16 have normal values and are consistent with those found by Farrell et al (1984) in the metallo complex; some discrepancies are noted in the values reported by Bales et al (1985).…”

“…The situation is thus comparable with that found in the structurally similar 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole (metronidazole) (Blaton, Peeters & De Ranter, 1979) in which the planes of the nitro group and imidazole ring are inclined at an angle of 4.3 o. The result confirms the conclusion of Bales et al (1985) that steric effects are responsible for the large angle of about 46 ° between the planes of the nitro group and imidazole rings found in the complex of misonidazole with PtC12.…”

“…The structure of a platinum(II) complex of misonidazole has been described (Farrell, Gomes Carneiro, Einstein, Jones & Skov, 1984;Bales et al, 1985) but that of the uncomplexed ligand has until now not been reported. Crystal of dimensions 0.5 × 0.15 × 0.15 mm selected for data collection.…”

Preparation and structure of silver complexes with 4-nitroimidazole

“…Nitroimidazoles are known to be effective radiosensitizers and chemotherapeutic agents both as free molecules (1)(2)(3) and when coordinated to metals like Pt, Ru, and Rh (4)(5)(6). The role played by the nitro groups in the coordination of these molecules has so far attracted little attention.…”

Multinuclear MR studies of Platinum(II) nitroimidazole complexes: 15N‐labelling and reactions with nucleotides

“…25 Further support for N-7 coordination of 5'-GMP was provided by the pH titration behaviour of the H-8 peak : inflections were observed corresponding to the deprotonation of the 5'-phosphate and N-1 protons for both the free ligand and the complex, but only 5'-GMP showed deprotonation of N-7 at low pD (2)(3)(4). Little change in the value of J(H-l', H-2') on platination of the purine base was observed, and therefore, in contrast to the analogous ammine complex, little change in the sugar ring conformation from 'S' towards 'N' (C-3'-endo) appears to occur in [Pt(MNZ),(5'-GMP),12'.…”