Preparation and structure of silver complexes with 4-nitroimidazole

Ségalas, Isabelle; Beauchamp, André L.

doi:10.1139/v92-127

Cited by 22 publications

(9 citation statements)

References 24 publications

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“…9). Similar polymeric chains have been reported for the silver(I)-4-nitroimidazolate complex, [Ag(4-NO 2 -im)] (4-NO 2 -imH = 4-nitroimidazole) [15], and also for metal-imidazolate complexes of Ni(II), Cu(II), Zn(II) and Ag(I) [14].…”

Section: Synthesis and Characterizationsupporting

confidence: 81%

Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles

et al. 2013

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a b s t r a c t[Ag 2 (9-aca) 2 ] (9-acaH = 9-anthracenecarboxylic acid) interacts with DMSO and a selection of substituted imidazoles giving [Ag 4 (DMSO) 4 (9-aca) 4 In the carboxylate/imidazole complexes 2-4, the imidazole ligand is in the neutral form, whilst in complexes 6-9 the imidazolate ligand is deprotonated and no carboxylate ligand is present. Attempted recrystallization of 4 from EtOH gives the metal-free, imidazolium salt, 2-Mebenz-imH 2 )(9-aca)ÁH 2 O (5). The X-ray crystal structures of complexes 1 and 2 and the salt 5 were determined. Antimicrobial screening showed that the Ag(I) complexes were substantially more active against the fungus Candida albicans than the bacterial species, methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli. Some of the complexes offer a good prognosis for Galleria mellonella (larvae of the greater wax moth) infected with a lethal dose of C. albicans cells.

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Section: Synthesis and Characterizationsupporting

confidence: 81%

Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles

et al. 2013

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“…Potential binding sites decrease progressively in the series 42 imidazole, 36a , 1-methylimidazole, 36b , and 1,3-dimethylimidazolium ion, 37 . A 1:1 molar mixture of 36a and CH 3 HgNO 3 in H 2 O yields 38a ; an ethanolic solution of 36a reacts with aqueous CH 3 HgNO 3 to form 36c , while 38b , the product of methylmercuration at both N1 and N3 according to the disproportionation reaction of eq 2, is obtained under neutral or basic conditions 42a. Similar results for 36a were reported by Rabenstein and co-workers. 42b, Precedents for eq 2 exist in the adenine/CH 3 Hg II 23a and xanthosine/CH 3 Hg II 38 systems (vide supra).…”

Section: 4 Imidazole 1-methylimidazole and 13-dimethylimidazolium Ionmentioning

confidence: 99%

Biomolecule−Mercury Interactions: Modalities of DNA Base−Mercury Binding Mechanisms. Remediation Strategies

2004

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“…Such type of deviation has been observed in Ag complexes with multifunctional ligands capable of making secondary interactions with the metal center. 34 The deviation from the linear geometry is because of the short-ranged interactions found in molecules of the compound. Thus, Ag ion is pseudo 5-coordinated, as depicted in Figure 4, inserted.…”

Section: Structure Of Complexmentioning

confidence: 99%

Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

Khan¹,

Ahmad²,

Gul³

et al. 2019

Turk J Chem

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2-Aminothiazole derivatives bear three nucleophilic centers, i.e. endocyclic N, exocyclic NH 2 , and S atom in the ring system. In addition to these centers there are π-electrons in the ring system which can also expectedly be involved in some sort of coordination. To the best of our knowledge the solid state coordination chemistry of such ligands has not been fully presented in the literature. These ligands (2-amino-4-methylthiazole and 2-amino-5-methylthiazole) were coupled with CoCl 2 under aerobic conditions to form tetrahedral complexes, bis(2-amino-4methylthiazole)dichlorocobalt(II) (1) and bis(2-amino-5-methylthiazole)dichlorocobalt(II) (2). Reaction of 2-amino-5-methylthiazole with AgNO 3 led to an expected two-coordinated, bis(2-amino-5-methylthiazole)silver(I) nitrate (3) as crystalline material. In all complexes the coordination behavior of the aminothiazole derivatives was identical, coordinating to the metal center through endocyclic N atom. The structures of these complexes were confirmed by single-crystal X-ray analysis. Compounds (1-3) were screened for their antimicrobial potency against gram-negative (E. sakazkii, E. coli, K. pneumoniae) and a gram-positive bacteria (S. aurus). Additionally, their role as enzyme inhibitors (acetylcholinesterase, AChE, and butyrylcholinesterase, BChE) and their free radical scavenging ability (2,2-Diphenyl-1-picrylhydrazyl, DPPH, and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid, ABTS) were studied. These ligands bear additional nucleophilic centers (S and NH 2) and can be involved in secondary interactions as confirmed by their solid-state structures. These interactions make the molecules biologically important and thus play a pivotal role in establishing the supramolecular network. We report here the coordination chemistry and selected biological applications of complexes 1-3.

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Preparation and structure of silver complexes with 4-nitroimidazole

Cited by 22 publications

References 24 publications

Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles

Synthesis, structure and biological activity of silver(I) complexes of substituted imidazoles

Biomolecule−Mercury Interactions: Modalities of DNA Base−Mercury Binding Mechanisms. Remediation Strategies

Methyl-substituted 2-aminothiazole–based cobalt(II) and silver(I) complexes:synthesis, X-ray structures, and biological activities

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