Platinum(IV) and platinum(II) anticancer complexes with biologically active releasable ligands

Štarha, Pavel; Křikavová, Radka

doi:10.1016/j.ccr.2023.215578

Cited by 10 publications

(1 citation statement)

References 243 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The experience gained in Pt(II)-based antitumor agents indicated that the use of the advantageous properties of octahedral Pt(IV) complexes was an efficient approach in developing effective agents for treating resistant tumor cells. On the other hand, the design of such compounds also enables their conjugation in axial positions with diverse biologically active ligands to achieve both improved and targeted delivery [70,[72][73][74][75][76]. Thus, a combinatory therapy can be developed through both the ligands and Pt(II)-species after accumulation and the reduction of the complex inside the tumor cells, where they act via several mechanisms on different cellular targets [77,78].…”

Section: Coordinative Compounds With Unsaturated Carboxylate With Ant...mentioning

confidence: 99%

Coordinative Compounds Based on Unsaturated Carboxylate with Versatile Biological Applications

Vasile Scaeteanu,

Badea,

Olar

2024

Molecules

View full text Add to dashboard Cite

This review presents an overview of the biological applications of coordinative compounds based on unsaturated carboxylates accompanied by other ligands, usually N-based heterocyclic species. The interest in these compounds arises from the valuable antimicrobial and antitumor activities evidenced by some species, as well as from their ability to generate metal-containing polymers suitable for various medical purposes. Therefore, we describe the recently discovered aspects related to the synthesis, structure, and biological activity of a wide range of unsaturated carboxylate-containing species and metal ions, originating mostly from 3d series. The unsaturated carboxylates encountered in coordinative compounds are acrylate, methacrylate, fumarate, maleate, cinnamate, ferulate, coumarate, and itaconate. Regarding the properties of the investigated compounds, it is worth mentioning the good ability of some to inhibit the development of resistant strains or microbial biofilms on inert surfaces or, even more, exert antitumor activity against resistant cells. The ability of some species to intercalate into DNA strands as well as to scavenge ROS species is also addressed.

show abstract

Section: Coordinative Compounds With Unsaturated Carboxylate With Ant...mentioning

confidence: 99%

Coordinative Compounds Based on Unsaturated Carboxylate with Versatile Biological Applications

Vasile Scaeteanu,

Badea,

Olar

2024

Molecules

View full text Add to dashboard Cite

show abstract

Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery

Wong,

Nie,

Wong

et al. 2024

Advanced Materials

View full text Add to dashboard Cite

Drug delivery is a key component of nanomedicine, and conventional delivery relies on the adsorption or encapsulation of drug molecules to a nanomaterial. Many delivery vehicles contain metal ions such as metal‐organic frameworks, metal oxides, transition metal dichalcogenides, MXene and noble metal nanoparticles. These materials have a high metal content and pose potential long‐term toxicity concerns leading to difficulties for clinical approval. In this review, we summarize recent developments in the use of drug molecules as ligands for metal coordination forming various nanomaterials and soft materials. In these cases, the drug‐to‐metal ratio is much higher than conventional adsorption‐based strategies. The drug molecules are divided into small‐molecule drugs, nucleic acids, and proteins. The formed hybrid materials mainly include nanoparticles and hydrogels, upon which targeting ligands can be grafted to improve efficacy and further decrease toxicity. The application of these materials for addressing cancer, viral infection, bacterial infection inflammatory bowel disease, and bone diseases is reviewed. In the end, some future directions are discussed from fundamental research, materials science, and medicine.This article is protected by copyright. All rights reserved

show abstract

Pd(II) and Pt(II) saccharinate complexes with two phosphine derivatives: Synthesis, anticancer and antiangiogenic activities

Icsel,

Yilmaz,

Aygun

et al. 2024

Applied Organom Chemis

View full text Add to dashboard Cite

As clinically used anticancer Pt(II) drugs have severe side effects, there is a growing interest for new metal complexes with great potential for cancer therapy. The current work aimed to prepare and characterize new Pd(II) and Pt(II) saccharinate (sac) complexes bearing pyridyl‐ and benzyldiphenylphosphines (PPh2Py and PPh2Bz, respectively), cis‐[Pd(sac)2(PPh2Py)2] (1), cis‐[PtCl(sac)(PPh2Py)2]·0.5DMF (2), cis‐[Pd(sac)2(PPh2Bz)2]·DMF (3) and trans‐[PtCl(sac)(PPh2Bz)2] (4) as promising anticancer and antiangiogenic drugs. The anticancer activity of the complexes was screened against seven cancer cell lines including HCT116 (colon), HepG2 (liver), MDA‐MB‐231 (breast), PANC‐1 (pancreatic), A549 (lung), C6 (glioma), DU145 (prostate) and normal human lung epithelial cells (BEAS‐2B). 1 and 2 did not show biological activity below 20 μM at 48 h, whereas 3 and 4 displayed significant cytotoxic effect on the cancer cells. 4 was the most potent complex (IC50 = 2.2–12.1 μM) and displayed much greater cytotoxicity than cisplatin in all the cancer cell lines. 4 caused apoptosis in HCT116 cells as evidenced by annexin V positivity and caspase 3/7 activity assays. Furthermore, the inhibition of antiapoptotic Bcl‐2 proteins by the complex suggested the intrinsic apoptosis. In addition, 4 greatly enhanced generation of intracellular reactive oxygen species (ROS) and consequently caused remarkable DNA double‐strand breaks in HCT116 cells. Moreover, the chick chorioallantoic membrane (CAM) assay was used to evaluate antiangiogenic potential of 4. The complex effectively inhibited angiogenesis at a dose of 50 ng, suggesting it as a promising multi‐targeted agent for antiangiogenic cancer treatment.

show abstract

Platinum(IV) and platinum(II) anticancer complexes with biologically active releasable ligands

Cited by 10 publications

References 243 publications

Coordinative Compounds Based on Unsaturated Carboxylate with Versatile Biological Applications

Coordinative Compounds Based on Unsaturated Carboxylate with Versatile Biological Applications

Metal–Drug Coordination Nanoparticles and Hydrogels for Enhanced Delivery

Pd(II) and Pt(II) saccharinate complexes with two phosphine derivatives: Synthesis, anticancer and antiangiogenic activities

Contact Info

Product

Resources

About