Platinum(II) substituted pyrrolidine complexes. Crystal structure of dichloride 1,2 diethyl 3 aminopyrrolidine PtII. Reactions with DNA and dinucleotides

Water-soluble platinum(II) complexes of diamine chelating ligands bearing amino-acid type substituents: the effect of the linked amino acid and the diamine chelate ring size on antitumor activity, and interactions with 5′-GMP and DNA

“…This phenomenon, which is indicative for a B ! C transformation with increasing winding of the DNA helix through rotation of the bases, appears to be related to the formation of short single-stranded segments containing unpaired bases [52][53][54][55][56][57][58]. In contrast, the results presented in previous work [37] for the parent compounds PtCl 2 (dap) and PtCl 2 (dab), showed the ellipticity of the positive band increasing with increasing values of r i and an upshift in the k max and k min .…”

Co-ordination chemistry of 3S-aminopyrrolidine and 3S-(methylamino)pyrrolidine: crystallisation of the two diastereomers of dichloro[3S-(R,S-methylamino)pyrrolidine]palladium(II)

“…3S-Aminopyrrolidine (S-ap) is a commercially available chiral diamine that has been little studied as a donor to metal ions, although several platinum() complexes of the parent ligand and substituted derivatives have been investigated in antitumour treatments. 2, 3 Aspects of its co-ordination chemistry are discussed in the present paper. In addition, the novel methylated derivative 3(S)-(methylamino)pyrrolidine, S-meap, has been prepared and complexes with Pd II and Pt II synthesized and characterised.…”

“…Inversion of the N Me centre is considered to succeed Pd-N Me bond rupture, as outlined for similar platinum() complexes. 3 It was not possible to examine the relation between rates of epimerisation and N Me -H exchange in organic solvents owing to the very low solubility of the complexes in such media. Compounds of the cations [M(S-meap) 2 ] 2ϩ (M = Pd or Pt) were readily obtained, but not characterised, as initial NMR studies revealed a large degree of isomeric complexity for these systems.…”

“…α(589. 3 [Cu(S-ap) 2 Br]ClO 4 . As for the chloride complex above using 100 mg [Cu(S-ap) 2 ][ClO 4 ] 2 ؒH 2 O and a 10% stoichiometric excess of LiBr in a total volume of 20 ml of MeOH.…”

Mechanistic and Conformational Studies on the Interaction of a Platinum(II) Complex Containing an Antiepileptic Drug, Levetiracetam, With Bovine Serum Albumin by Optical Spectroscopic Techniques in Aqueous Solution

“…The pyrrolidine derivatives fall into an important class of organic compounds, and they have received attention of biochemists because of their biochemical activities [1][2][3]. Furthermore, a great many pyrrolidine complexes have also provoked a great interest in their diverse spectra of biological and pharmaceutical activities, such as antibacterial and antitumor activities [4][5][6][7][8]. Coordination compounds of platinum have an especially rich history due to the clinical success of cisplatin and related anticancer drugs [9,10].…”