Platinum drugs binding to human serum albumin: Effect of non-steroidal anti-inflammatory drugs

Wiglusz, Katarzyna; Trynda-Lemiesz, Lilianna

doi:10.1016/j.jphotochem.2014.05.013

Cited by 26 publications

(17 citation statements)

References 40 publications

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“…In addition, numerous studies proved that drugs usually bind to high-affinity sites with typical association constants in the range of 10 4 –10 6 M −1 . In particular, Wilgusz et al [ 58 ] proved that the anti-inflammatory drug of third generation meloxicam is able to bind to HSA in more than 99% with association constant of the order of 10 5 M −1 ; furthermore, aspirin and indomethacin binding constant to HSA–aspirin/indometacin is approximately 1.4 × 10 4 and 48.9 × 10 4 M −1 , respectively [ 59 ]. The range of binding constants for Q 7-MeGlu and Q to HSA, as obtained in the present study, indicates a relatively good interaction between sugar derivatives of quercetin and its aglycon and HSA.…”

Section: Resultsmentioning

confidence: 99%

Bioactivity In Vitro of Quercetin Glycoside Obtained in Beauveria bassiana Culture and Its Interaction with Liposome Membranes

et al. 2017

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Quercetin (Q) was used as substrate for regioselective glycosylation at the C-7 position catalyzed by Beauveria bassiana AM278 strain. As a result the glycoside quercetin 7-O-β-d-(4″-O-methyl)glucopyranoside (Q 7-MeGlu) was formed. The goal of the studies was to determine the anti-oxidative (liposome membrane protection against free radicals IC50Q 7-MeGlu = 5.47 and IC50Q = 4.49 µM) and anti-inflammatory (COX-1 and COX-2 enzymes activity inhibition) properties of Q 7-MeGlu as compared to Q. Every attempt was made to clarify the antioxidant activity of these molecules, which are able to interact with egg phosphatidylcholine liposomes, using a fluorometric method (by applying the probes MC540, TMA-DPH and DPH). The results indicated that Q 7-MeGlu and Q are responsible for increasing the packing order, mainly in the hydrophilic but also in hydrophobic regions of the membrane (Q > Q 7-MeGlu). These observations, confirmed by a 1H-NMR method, are key to understanding their antioxidant activity which is probably caused by the stabilizing effect on the lipid membranes. The results showed that Q 7-MeGlu and Q have ability to quench the human serum albumin (HSA) intrinsic fluorescence through a static quenching mechanism. The results of thermodynamic parameters indicated that the process of formation complexes between studied molecules and HSA was spontaneous and caused through Van der Waals interactions and hydrogen bonding.

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Section: Resultsmentioning

confidence: 99%

Bioactivity In Vitro of Quercetin Glycoside Obtained in Beauveria bassiana Culture and Its Interaction with Liposome Membranes

et al. 2017

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“…Since Rosenberg's group found that cisplatin showed antitumor activity against sarcoma 180 and leukemia L1210 cells, cisplatin and its platinum (Pt) (II) derivatives have become one of the most effective anticancer drugs to treat various tumors including testes, ovary, head, lung, melanoma, and others. [1][2][3] However, dose-dependent toxicity and intrinsic or acquired drug resistances seriously hinder the clinical application of Pt (II) based chemotherapy. [4][5][6] Then, high tumor specificity and low toxicity of novel platinum complexes are designed and screened, with Pt (IV) complex being one of the most promising strategies.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Platinum (IV) Complex‐Based Delivery Systems to Improve Platinum (II) Anticancer Therapy

Han

Sun

Wang

et al. 2015

Medicinal Research Reviews

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Cisplatin and its platinum (Pt) (II) derivatives play a key role in the fight against various human cancers such as testicular, ovarian, head and neck, lung tumors. However, their application in clinic is limited due to dose- dependent toxicities and acquired drug resistances, which have prompted extensive research effort toward the development of more effective Pt (II) delivery strategies. The synthesis of Pt (IV) complex is one such an area of intense research fields, which involves their in vivo conversion into active Pt (II) molecules under the reducing intracellular environment, and has demonstrated encouraging preclinical and clinical outcomes. Compared with Pt (II) complexes, Pt (IV) complexes not only exhibit an increased stability and reduced side effects, but also facilitate the intravenous-to-oral switch in cancer chemotherapy. The overview briefly analyzes statuses of Pt (II) complex that are in clinical use, and then focuses on the development of Pt (IV) complexes. Finally, recent advances in Pt (IV) complexes in combination with nanocarriers are highlighted, addressing the shortcomings of Pt (IV) complexes, such as their instability in blood and irreversibly binding to plasma proteins and nonspecific distribution, and taking advantage of passive and active targeting effect to improve Pt (II) anticancer therapy.

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“…Our results indicate a significant impact of the presence of studied drugs in the solution on the result of determination of the human albumin. The possible explanation could be the ability of albumin to form a complex with both captopril and cisplatin …”

Section: Discussionmentioning

confidence: 99%

Captopril apparently increase and cisplatin apparently decrease human albumin concentration in artificial urinary solutions

Kuzioła

Marczewska

Marczewski³

2017

Clinical Laboratory Analysis

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Platinum drugs binding to human serum albumin: Effect of non-steroidal anti-inflammatory drugs

Cited by 26 publications

References 40 publications

Bioactivity In Vitro of Quercetin Glycoside Obtained in Beauveria bassiana Culture and Its Interaction with Liposome Membranes

Bioactivity In Vitro of Quercetin Glycoside Obtained in Beauveria bassiana Culture and Its Interaction with Liposome Membranes

Recent Advances in Platinum (IV) Complex‐Based Delivery Systems to Improve Platinum (II) Anticancer Therapy

Captopril apparently increase and cisplatin apparently decrease human albumin concentration in artificial urinary solutions

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