Platinum-Based Induction Chemotherapy Followed by Radiation as Definitive Treatment for Patients with Locally Advanced Cancer of the Oral Cavity, Oropharynx and Hypopharynx. A Retrospective Analysis of 32 Cases

Fountzilas, George; Daniilidis, J; Kosmidis, P.; Sridhar, Kasi S.; Kalogera‐Fountzila, Anna; Banis, K.; Avramidis, V.; Tsavdaridis, D.; Themelis, C; Zaramboukas, Thomas

doi:10.1080/1120009x.1991.11739090

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Concurrent with the conservative non-surgical treatment for laryngeal cancer, a similar approach has been adopted in treating oropharyngeal [4,5] and hypopharyngeal [6] squamous cell carcinomas. The effect of a preferred oncologic non-surgical management of the above squamous cell carcinomas resulted in significantly fewer neck dissections after 1991.…”

Section: Discussionmentioning

confidence: 99%

Neck dissection: cause and effect

et al. 2015

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This study demonstrates changes in neck dissection procedures over time. There is an increasing preference for conservative treatment for epithelial cancers. In addition, there is a large increase in both the diagnosis and surgical treatment of thyroid cancer. This shift may have a great effect on residents' learning curves and on their ability to achieve competency in performing neck dissections.

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Section: Discussionmentioning

confidence: 99%

Neck dissection: cause and effect

et al. 2015

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Does Substitution of Surgery with Induction Chemotherapy Preserve Organ Function in Inoperable Head and Neck Cancer? A Retrospective Analysis of 73 Cases

Fountzilas

Kosmidis

Zamboglou

et al. 1994

Journal of Chemotherapy

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From August, 1984 until May, 1991, 154 patients with locally advanced head and neck cancer were treated with 3 cycles of platinum-containing induction chemotherapy followed by definitive radiotherapy. Among them, there were 32 patients with cancer of oropharynx or hypopharynx and 41 patients with cancer of larynx, who were treated with this combined approach with the intention of preserving the involved organ. After the completion of chemotherapy 5 (16%) patients with pharyngeal tumors achieved a complete response (CR) and 14 (44%) a partial response (PR). After the completion of radiotherapy the CR rate was increased to 38%. After induction chemotherapy 7 (17%) of the 41 patients with cancer of the larynx achieved a CR and 25 (61%) a PR. The CR rate was tripled (68%) following radiotherapy and salvage surgery. So far, 8 complete responders with pharyngeal and 6 with laryngeal tumors relapsed mainly locoregionally. With a minimum follow-up of 22 months, median time to progression was 8 months for patients with cancer of the pharynx and 13 months for patients with cancer of the larynx. Median survival for these two groups of patients was 13 and 24 months respectively. In patients with locally advanced cancer of the oropharynx, hypopharynx or larynx induction chemotherapy followed by radiotherapy may delay in many or even omit in a few patients the necessity of radical surgery without compromising survival.

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Cisplatin and Continuous Infusion of Fluorouracil Followed by Radiation and Weekly Carboplatin in the Treatment of Locally Advanced Head and Neck Cancer: A Hellenic Cooperative Oncology Group Study

Fountzilas

Kosmidis

Sridhar

et al. 1996

Cancer Investigation

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Induction chemotherapy followed by radiation has been extensively studied in an effort to improve local control and possibly overall survival of patients with locally advanced head and neck cancer. From June 1989 until May 1991, 39 patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN) were treated with 3 cycles of induction chemotherapy, consisting of cisplatin (100 mg/m2 d 1) and fluorouracil (1000 mg/m2 d 2-6) followed by radiation potentiated by weekly administration of carboplatin (60 mg/m2). Surgery was performed in selected patients with residual disease after the combined modality approach. Four cycles of adjuvant chemotherapy with carboplatin (325 mg/m2) and bleomycin (15 u) were administered in those patients who demonstrated a partial response after locoregional treatment. There were 36 men and 3 women with a median age of 56 (range 39-74) years and Karnofsky performance status of 70 (range 60-100). The primary site of the tumor was nasopharynx (8), oropharynx (8), hypopharynx (3), oral cavity (4), larynx (13), paranasal sinus (2), and salivary glands (1). Thirty-two (82%) patients presented with stage IV disease. After the completion of induction chemotherapy, 14 (36%, 95% CI 21-53%) patients achieved a complete response (CR). This CR rate was increased to 56% (95% CI, 42-74%) after locoregional treatment. Main toxicities included nausea/vomiting (56%), leukopenia (40%), anemia (30%), thrombocytopenia (10%), stomatitis (28%), diarrhea (17%), and alopecia (12%). Median relapse-free survival was 18 (1-50) months, median time to progression was 13 (0.3-58.5) months, and median survival 19 (0.3-59) months. Induction chemotherapy with cisplatin and fluorouracil followed by radiation potentiated with carboplatin is feasible. However, this combined modality approach, as applied in the present study, does not appear to yield superior results than those reported with chemotherapy followed by radiation alone.

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Platinum-Based Induction Chemotherapy Followed by Radiation as Definitive Treatment for Patients with Locally Advanced Cancer of the Oral Cavity, Oropharynx and Hypopharynx. A Retrospective Analysis of 32 Cases

Cited by 3 publications

References 14 publications

Neck dissection: cause and effect

Neck dissection: cause and effect

Does Substitution of Surgery with Induction Chemotherapy Preserve Organ Function in Inoperable Head and Neck Cancer? A Retrospective Analysis of 73 Cases

Cisplatin and Continuous Infusion of Fluorouracil Followed by Radiation and Weekly Carboplatin in the Treatment of Locally Advanced Head and Neck Cancer: A Hellenic Cooperative Oncology Group Study

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