Platinated graphene oxide: A nanoplatform for efficient gene-chemo combination cancer therapy

Liu, Peng; Wang, Shengfeng; Liu, Xuanjun; Ding, Jinsong; Zhou, Wenhu

doi:10.1016/j.ejps.2018.06.009

Cited by 20 publications

(12 citation statements)

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“…CisPt-GO NPs, co-loaded with an antisense microRNA-21 (Anti-miR-21), were tested as a potential RNAi agent. This NC delivered anti-miR-21 and CisPt into A549 tumor cells, which led to strongly improved cell apoptosis and therapeutic efficiency ( Figure 14) [115]. Figure 13.…”

Section: Figure 11mentioning

confidence: 99%

“…The NCs were able to suppress resistance and enhance the effect of first-line drugs against tuberculosis. The high antimycobacterial efficacy of GO, its synergism with isoniazid, and the main anti-biofilm effect were observed for combinations between GO and the two first-line tuberculostatics [115].…”

Section: Antibacterial Propertiesmentioning

confidence: 99%

“…Scheme of the preparation of graphene oxide and cisplatin (CisPt) complex, with the adsorption of Anti-miR-21 for cancer treatment. Reprinted from [115] with permission from Elsevier, copyright 2019.…”

Section: Figure 11mentioning

confidence: 99%

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Graphenic Materials for Biomedical Applications

2019

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Graphene-based nanomaterials have been intensively studied for their properties, modifications, and application potential. Biomedical applications are one of the main directions of research in this field. This review summarizes the research results which were obtained in the last two years (2017-2019), especially those related to drug/gene/protein delivery systems and materials with antimicrobial properties. Due to the large number of studies in the area of carbon nanomaterials, attention here is focused only on 2D structures, i.e. graphene, graphene oxide, and reduced graphene oxide.

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Section: Figure 11mentioning

confidence: 99%

Section: Antibacterial Propertiesmentioning

confidence: 99%

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Graphenic Materials for Biomedical Applications

2019

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“…In the absence of NGO, a fast CisPt release was recorded (M t /M 0 of 0.90 after 20 h), with high α value indicating a low affinity of the drug towards the carrier phase (γ-Fe 2 O 3 ). On other hand, the strong interaction between CisPt and NGO [60,61,62] resulted in a more extended release over time (F max < 0.8 even after 250 h), with the same affinity (3.54) recorded for either NGO or γ-Fe 2 O 3 @NGO. The presence of γ-Fe 2 O 3 in γ-Fe 2 O 3 @NGO was found to slow the release, with reduced kinetic constant (k R ) and t 1/2 values moving from 19.01 (NGO) to 29.38 (γ-Fe 2 O 3 @NGO) h. This could be ascribed to the hindrance to the drug diffusion from the NGO to the solvent phase by the oleate coating of γ-Fe 2 O 3 nanoparticles [55].…”

Section: Resultsmentioning

confidence: 99%

Magnetic Graphene Oxide Nanocarrier for Targeted Delivery of Cisplatin: A Perspective for Glioblastoma Treatment

et al. 2019

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Selective vectorization of Cisplatin (CisPt) to Glioblastoma U87 cells was exploited by the fabrication of a hybrid nanocarrier composed of magnetic γ-Fe2O3 nanoparticles and nanographene oxide (NGO). The magnetic component, obtained by annealing magnetite Fe3O4 and characterized by XRD measurements, was combined with NGO sheets prepared via a modified Hummer’s method. The morphological and thermogravimetric analysis proved the effective binding of γ-Fe2O3 nanoparticles onto NGO layers. The magnetization measured under magnetic fields up to 7 Tesla at room temperature revealed superparamagnetic-like behavior with a maximum value of MS = 15 emu/g and coercivity HC ≈ 0 Oe within experimental error. The nanohybrid was found to possess high affinity towards CisPt, and a rather slow fractional release profile of 80% after 250 h. Negligible toxicity was observed for empty nanoparticles, while the retainment of CisPt anticancer activity upon loading into the carrier was observed, together with the possibility to spatially control the drug delivery at a target site.

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“…g ., hydroxyl and carboxyl groups) for drug conjugation and further modifications 37 , 38 , 39 , 40 , 41 . For example, the photosensitizer chlorin e6 (Ce6) was loaded onto GO via physisorption 42 , 43 , and cisplatin was conjugated on GO via ester bond which facilitated the subsequent microRNA adsorption to realize gene–chemo combinations 44 . Herein, GO was exploited as the nano-delivery system to realize the co-delivery of CisPt and Ce6 (designated as GO/CisPt/Ce6).…”

Section: Introductionmentioning

confidence: 99%

A smart MnO2-doped graphene oxide nanosheet for enhanced chemo-photodynamic combinatorial therapy via simultaneous oxygenation and glutathione depletion

Liu

Xie

Liu

et al. 2021

Acta Pharmaceutica Sinica B

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The combination of chemotherapy and photodynamic therapy provides a promising approach for enhanced tumor eradication by overcoming the limitations of each individual therapeutic modality. However, tumor is pathologically featured with extreme hypoxia together with the adaptable overexpression of anti-oxidants, such as glutathione (GSH), which greatly restricts the therapeutic efficiency. Here, a combinatorial strategy was designed to simultaneously relieve tumor hypoxia by self-oxygenation and reduce intracellular GSH level to sensitize chemo-photodynamic therapy. In our system, a novel multi-functional nanosystem based on MnO 2 -doped graphene oxide (GO) was developed to co-load cisplatin (CisPt) and a photosensitizer (Ce6). With MnO 2 doping, the nanosystem was equipped with intelligent functionalities: (1) catalyzes the decomposition of H 2 O 2 into oxygen to relieve the tumor hypoxia; (2) depletes GSH level in tumor cells, and (3) concomitantly generates Mn 2+ to proceed Fenton-like reaction, all of which contribute to the enhanced anti-tumor efficacy. Meanwhile, the surface hyaluronic acid (HA) modification could facilitate the targeted delivery of the nanosystem into tumor cells, thereby resulting in amplified cellular toxicity, as well as tumor growth inhibition in nude mice model. This work sheds a new light on the development of intelligent nanosystems for synergistic combination therapy via regulating tumor microenvironment.

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Platinated graphene oxide: A nanoplatform for efficient gene-chemo combination cancer therapy

Cited by 20 publications

References 50 publications

Graphenic Materials for Biomedical Applications

Graphenic Materials for Biomedical Applications

Magnetic Graphene Oxide Nanocarrier for Targeted Delivery of Cisplatin: A Perspective for Glioblastoma Treatment

A smart MnO2-doped graphene oxide nanosheet for enhanced chemo-photodynamic combinatorial therapy via simultaneous oxygenation and glutathione depletion

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