Platform Technologies for Directly Reconstructing 3D Living Biomaterials

Jayasinghe, Suwan N.; Auguste, Jensen; Scotton, Chris J.

doi:10.1002/adma.201503001

Cited by 26 publications

(19 citation statements)

References 30 publications

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“…619 The composition of the solution for loading the cells has a significant impact on the electrospinnability of the suspension and the viability of the cells encapsulated in the fibers. 620 Electrospinning from a mixture of cells and polymer solution will subject the cells to the viscous force. In this case, a coaxial electrospinning setup is needed.…”

Section: Electrospun Nanofibers With “Smart” Propertiesmentioning

confidence: 99%

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

et al. 2019

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Electrospinning is a versatile and viable technique for generating ultrathin fibers. Remarkable progress has been made with regard to the development of electrospinning methods and engineering of electrospun nanofibers to suit or enable various applications. We aim to provide a comprehensive overview of electrospinning, including the principle, methods, materials, and applications. We begin with a brief introduction to the early history of electrospinning, followed by discussion of its principle and typical apparatus. We then discuss its renaissance over the past two decades as a powerful technology for the production of nanofibers with diversified compositions, structures, and properties. Afterward, we discuss the applications of electrospun nanofibers, including their use as “smart” mats, filtration membranes, catalytic supports, energy harvesting/conversion/storage components, and photonic and electronic devices, as well as biomedical scaffolds. We highlight the most relevant and recent advances related to the applications of electrospun nanofibers by focusing on the most representative examples. We also offer perspectives on the challenges, opportunities, and new directions for future development. At the end, we discuss approaches to the scale-up production of electrospun nanofibers and briefly discuss various types of commercial products based on electrospun nanofibers that have found widespread use in our everyday life.

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Section: Electrospun Nanofibers With “Smart” Propertiesmentioning

confidence: 99%

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

et al. 2019

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“…In summary, BES extends the available toolkit for cell microencapsulation, and integration with other techniques, such as electrospinning, provides the possibility to form simultaneously complex living three-dimensional (3D) architectures for potential applications in regenerative medicine (Jayasinghe et al, 2015).…”

Section: Bioactive Cargos Electrosprayed Inside Carriersmentioning

confidence: 99%

Electrospraying: Possibilities and Challenges of Engineering Carriers for Biomedical Applications—A Mini Review

2019

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Electrospraying, a liquid atomization-based technique, has been used to produce and formulate micro/nanoparticular cargo carriers for various biomedical applications, including drug delivery, biomedical imaging, implant coatings, and tissue engineering. In this mini review, we begin with the main features of electrospraying methods to engineer carriers with various bioactive cargos, including genes, growth factors, and enzymes. In particular, this review focuses on the improvement of traditional electrospraying technology for the fabrication of carriers for living cells and providing a suitable condition for gene transformation. Subsequently, the major applications of the electrosprayed carriers in the biomedical field are highlighted. Finally, we finish with conclusions and future perspectives of electrospraying for high efficiency and safe production.

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“…Electrospinning is another method that has been widely employed to make collagen scaffolds for skin substitutes, despite their intrinsically smaller pore size and resultantly decreased cell infiltration compared with freeze‐dried sponges . The use of organic solvents for electrospinning collagen and the subsequent chemical crosslinking of the scaffold may lead to its denaturation and subsequent reduced keratinocyte attachment .…”

Section: Natural Biomaterialsmentioning

confidence: 99%

Biomaterials for Skin Substitutes

Sheikholeslam

Wright

Jeschke

et al. 2017

Adv Healthcare Materials

159

126

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Patients with extensive burns rely on the use of tissue engineered skin due to a lack of sufficient donor tissue, but it is a challenge to identify reliable and economical scaffold materials and donor cell sources for the generation of a functional skin substitute. The current review attempts to evaluate the performance of the wide range of biomaterials available for generating skin substitutes, including both natural biopolymers and synthetic polymers, in terms of tissue response and potential for use in the operating room. Natural biopolymers display an improved cell response, while synthetic polymers provide better control over chemical composition and mechanical properties. It is suggested that not one material meets all the requirements for a skin substitute. Rather, a composite scaffold fabricated from both natural and synthetic biomaterials may allow for the generation of skin substitutes that meet all clinical requirements including a tailored wound size and type, the degree of burn, the patient age, and the available preparation technique. This review aims to be a valuable directory for researchers in the field to find the optimal material or combination of materials based on their specific application.

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Platform Technologies for Directly Reconstructing 3D Living Biomaterials

Cited by 26 publications

References 30 publications

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications

Electrospraying: Possibilities and Challenges of Engineering Carriers for Biomedical Applications—A Mini Review

Biomaterials for Skin Substitutes

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