Electrospraying: Possibilities and Challenges of Engineering Carriers for Biomedical Applications—A Mini Review

Wang, Jiamian; Jansen, John A.; Yang, Fang

doi:10.3389/fchem.2019.00258

Cited by 72 publications

(50 citation statements)

References 80 publications

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“…The dripping mode gives way to micro dripping, then spindle, Taylor cone jet, and multiplet mode. Obtaining a continuous jet is important for determining the droplet size and morphology which depends on interplay of factors related to the polymer liquid such as density, concentration, surface tension, conductivity [55], molecular weight, viscosity and solvent; and process parameters such as gravity, applied voltage, flow rate, capillary diameter, and distance of the collector from the capillary tip [56]. Among natural polymers that have been applied in electrospraying are chitosan, cellulose and alginate [57].…”

Section: Techniques Based On Drop Generation Methodsmentioning

confidence: 99%

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Ngwuluka¹,

Abu-Thabit²,

Uwaezuoke³

et al. 2021

Nano- And Microencapsulation - Techniques and Applications

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Encapsulation, specifically microencapsulation is an old technology with increasing applications in pharmaceutical, agrochemical, environmental, food, and cosmetic spaces. In the past two decades, the advancements in the field of nanotechnology opened the door for applying the encapsulation technology at the nanoscale level. Nanoencapsulation is highly utilized in designing effective drug delivery systems (DDSs) due to the fact that delivery of the encapsulated therapeutic/diagnostic agents to various sites in the human body depends on the size of the nanoparticles. Compared to microencapsulation, nanoencapsulation has superior performance which can improve bioavailability, increase drug solubility, delay or control drug release and enhance active/passive targeting of bioactive agents to the sites of action. Encapsulation, either micro- or nanoencapsulation is employed for the conventional pharmaceuticals, biopharmaceuticals, biologics, or bioactive drugs from natural sources as well as for diagnostics such as biomarkers. The outcome of any encapsulation process depends on the technique employed and the encapsulating material. This chapter discusses in details (1) various physical, mechanical, thermal, chemical, and physicochemical encapsulation techniques, (2) types and classifications of natural polymers (polysaccharides, proteins, and lipids) as safer, biocompatible and biodegradable encapsulating materials, and (3) the recent advances in using lipids for therapeutic and diagnostic applications. Polysaccharides and proteins are covered in the second part of this chapter.

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Section: Techniques Based On Drop Generation Methodsmentioning

confidence: 99%

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Ngwuluka¹,

Abu-Thabit²,

Uwaezuoke³

et al. 2021

Nano- And Microencapsulation - Techniques and Applications

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“…These characteristics and properties are of extreme interest for the production of micro and nano structures for the food industry, as the recent increase in publications and applications in this area shows (Costa et al, 2019;Deng, Kang, Liu, Feng, & Zhang, 2018;García-Moreno et al, 2018;Liao, Loh, Tian, Wang, & Fane, 2018;Rodrigues et al, 2020;Senthil Muthu Kumar et al, 2019). Parameters that influence structure morphology include voltage, tip-to-collector distance, flow rate, the selected solvent and polymer, its concentration and the viscosity of the solution obtained with it (Costa et al, 2019;García-Moreno et al, 2018;Marques et al, 2019;Senthil Muthu Kumar et al, 2019;Wang, Jansen, & Yang, 2019).…”

Section: Introductionmentioning

confidence: 99%

Food-grade hydroxypropyl methylcellulose-based formulations for electrohydrodynamic processing: Part I – Role of solution parameters on fibre and particle production

Prieto¹,

Lagarón²,

Pastrana³

et al. 2021

Food Hydrocolloids

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Electrohydrodynamic (EHD) processing allows the production of micro and nano structures with high surfacearea-to-volume ratio from biopolymers and environmentally friendly solvents. Such structures hold a very significant potential for application in the food area. The aim of this work was to assess the role of solution parameters in the formation of hydroxypropyl methylcellulose (HPMC)-based micro and nanostructures through EHD processing, establishing a relationship between variables such as viscosity and concentration, and processing zones (i.e., combinations of processing conditions that move the system towards electrospinningfibres are formedor electrosprayingparticles are formed).Micro and nano structures were produced through electrospinning and electrospraying using HPMC with low (HPMC LMW) and high (HPMC HMW) molecular weight. Solutions were characterized regarding surface tension, conductivity, viscosity, zero-shear rate and specific viscosity. Plotting specific viscosity versus concentration allowed determining the electrospraying and electrospinning zones, which were confirmed through scanning electron microscopy analysis. HPMC LMW led to the formation of particles. For concentrations between 1 and 2% (w/v) rod like particles were formed, and round particles were obtained for concentrations ranging from 3 to 6% (w/v). The mean particle diameter varied between 833 and 1188 nm, while the aspect ratio ranged from 1.3 to 3.7. Nanofibres were generated using HPMC HMW, being beaded fibres produced at a concentration of 1% (w/v) and smooth fibres produced for concentrations between 1.5 and 2.25% (w/v). The developed nanofibres displayed a mean diameter ranging between 79 and 161 nm.Electrospraying and electrospinning zones were successfully determined for HPMC LMW and HMW. Nevertheless, near transition zones variability regarding the obtained morphology was observed once other processing parameters (e.g., flow rate) can influence the morphology of fibers and particles.

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“…Poly( d , l -lactide-co-glycolic acid) (PLGA) has been extensively used as a bioscaffold, biomembrane and drug release carrier in the field of biomaterials because of its high biocompatibility and biodegradability [ 19 , 20 ]. PLGA microspheres were developed via emulsion or electrospray to encapsulate and deliver drugs in a controlled manner [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Development of an antimicrobial peptide-loaded mineralized collagen bone scaffold for infective bone defect repair

Jin

Xiang

et al. 2020

Regenerative Biomaterials

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The repair of infective bone defects is a great challenge in clinical work. It is of vital importance to develop a kind of bone scaffold with good osteogenic properties and long-term antibacterial activity for local anti-infection and bone regeneration. A porous mineralized collagen (MC) scaffold containing poly(d,l-lactide-co-glycolic acid) (PLGA) microspheres loaded with two antibacterial synthetic peptides, Pac-525 or KSL-W was developed and characterized via scanning electron microscopy (SEM), porosity measurement, swelling and mechanical tests. The results showed that the MC scaffold embedded with smooth and compact PLGA microspheres had a positive effect on cell growth and also had antibacterial properties. Through toxicity analysis, cell morphology and proliferation analysis and alkaline phosphatase evaluation, the antibacterial scaffolds showed excellent biocompatibility and osteogenic activity. The antibacterial property evaluated with Staphylococcus aureus and Escherichia coli suggested that the sustained release of Pac-525 or KSL-W from the scaffolds could inhibit the bacterial growth aforementioned in the long term. Our results suggest that the antimicrobial peptides-loaded MC bone scaffold has good antibacterial and osteogenic activities, thus providing a great promise for the treatment of infective bone defects.

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Electrospraying: Possibilities and Challenges of Engineering Carriers for Biomedical Applications—A Mini Review

Cited by 72 publications

References 80 publications

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Natural Polymers in Micro- and Nanoencapsulation for Therapeutic and Diagnostic Applications: Part I: Lipids and Fabrication Techniques

Food-grade hydroxypropyl methylcellulose-based formulations for electrohydrodynamic processing: Part I – Role of solution parameters on fibre and particle production

Development of an antimicrobial peptide-loaded mineralized collagen bone scaffold for infective bone defect repair

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