Platelets: Small in Size But Essential in the Regulation of Vascular Homeostasis　– Translation From Basic Science to Clinical Medicine –

An association of platelet indices with blood pressure in Beijing adults

“…Several studies have reported that platelet activation has a relationship with cardiovascular morbidity and mortality. [12–14] Increased platelet activation and aggregation are involved in the pathogenesis of elevated blood pressure, which is also associated with hypertensive risk factors. [15–18] Many researchers have illustrated that the platelet occupy was an important position in mediating immune response and maintaining the vascular homeostasis, atherosclerosis, and an inflammation.…”

A method and preliminary results of <i>in silico</i> computer simulation for the formation of mix thrombi with platelet and fibrin

“…Indeed, we have focused on the relatively new concept of "cell based coagulation" where activation of coagulation cascade occurs on cell membrane rather than liquid phase [1,16]. Strength of our model shown in this paper is that the results of simulation calculations were validated by our in vivo experiments [1,17,18].…”

What is the meaning of P2Y12 reaction units in patients with essential thrombocythemia?

“…Some suggest higher risk of thrombus formation in patients with ET [5] , [6] , [7] . In general, increased platelet cell count correlates with higher thrombogenicity mostly due to increased probability for adhesion and cohesion of platelets [8] . The same is true that the risk of bleeding increases in patients with reduced platelet count unless the sizes of individual platelet cells become bigger than normal [9] .…”

“…A platelet is a small cell, but the exact functional regulation mechanism in this cell is yet to be clarified [8] . Unlike the concepts used for developing “Verify Now,” some reports suggest a relevant role of both P2Y 1 and P2Y 12 for increasing intra-cellular calcium ion concentrations [20] .…”

“…If we really want to establish the logic for “personalized medicine” for the use of P2Y 12 ADP receptor inhibitors, quantitative understanding of the relationship between the dose taken as drugs, the actual P2Y 12 ADP receptor blockage (e.g. number of receptors blocked/number of available receptors) [8] , and the quantification of the heterogeneity between actual P2Y 12 ADP receptor blockage and cell response (such as number of GPIIb/IIIa proteins changed to activated form, number of dense granules released, number of fibrinogen molecules released from activated platelet, etc.) is necessary.…”